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Jaise Mariya George,Beena Mathew 한국화학공학회 2021 Korean Journal of Chemical Engineering Vol.38 No.3
β-Cyclodextrin (β-CD) modified gold nanoparticles (AuNP) were rapidly synthesized using microwave assisted procedure. Parameters, such as time, pH and concentrations of β-CD and gold, were optimized for the synthesis of β-CD-AuNP. The addition of enantiomers and racemic mixture of hydroxychloroquine (R-HCQ, S-HCQ and RS-HCQ) drugs and their interaction with β-CD led to a red shift in the surface plasmon resonance of β-CD-AuNP. The changes associated with the introduction of HCQ in β-CD-AuNP were studied using various characterization techniques such as UV-vis, FT-IR, XRD, dynamic light scattering, zeta potential, transmission electron microscopy, fluorescence spectroscopy and electrochemical techniques. The host-guest interaction of β-cyclodextrin with S-HCQ, RHCQ and RS-HCQ resulted in the aggregation of gold nanoparticles. The surface plasmon resonance at 521 nm for β- CD-AuNP was shifted to 600, 620 and 670 nm on the addition of S-HCQ, R-HCQ and RS-HCQ, respectively, with a color change from pink to blue. The selectivity and sensitivity of the developed system for RS-HCQ were investigated and the limit of detection (LOD=3 s/m) was found to be 2.61, 0.15, and 0.85 nM for optical, fluorescence and electrochemical methods, respectively. The successful monitoring of RS-HCQ drug in pharmaceutical samples is possible with these techniques.
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Bony K. John,Chinnu R. Thara,Binila K. Korah,Neenamol John,Beena Mathew 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.126 No.-
This work deals with the synthesis of facile, water-soluble, and blue-emitting carbon quantum dots(CQDs) from Plumbago indica leaves by a hydrothermal method with a quantum yield of 16 %. The biomassPlumbago indica leaves exhibit several advances such as easy availability, cost-effectiveness, nontoxic,green source, and not requiring any sophisticated techniques to develop the sensor. The optical,morphological, structural, and compositional properties of the CQDs were confirmed by various characterizationmethods. As a fluorescent probe, CQDs exhibited good linear response to picric acid (PA) with alimit of detection (LOD) of 18 nM. The sensing mechanism involves a combination of static quenching andfluorescence resonance energy transfer (FRET). In the electrochemical sensing method, the differentialpulse voltammetric (DPV) technique was performed using a CQD-modified gold electrode with a LODof 0.35 nM for PA. Using fresh carrots as a model sample, the antioxidant activity of PVA, CQD, and aPVA-CQD mixture was qualitatively determined. The in vitro cytotoxicity analysis of CQDs by MTT assayusing the L6 cell line confirmed its non-toxic behaviour. This work is noteworthy because it offers a newattempt to identify toxic PA from biomass-derived precursor material and finds future applications in thefood industry.
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