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Vinay Kumar Banka,김영주,이윤상,정재민 대한방사성의약품학회 2020 Journal of radiopharmaceuticals and molecular prob Vol.6 No.2
[99mTc]Tc-Hexamethylpropylene amine oxime (HMPAO) is currently used as a regional cerebral blood flow imaging agent for single photon emission computed tomography (SPECT). The HMPAO ligand exists in two isomeric forms: d,l and meso showing different properties in vivo. Later studies indicated that brain uptake patterns of 99mTc-complexes formed from separated enantiomers differed. Separation of enantiomers is difficult by fractional crystallizations method. Usually, the substance is obtained in low chemical yield in a time-consuming procedure. Furthermore, the final product still contains some impurity. So we have developed new efficient route for synthesis of R,R - and S,S -HMPAO enantiomeric compounds in 6-steps. Nucleophilic substitution (SN2) reactions of 2,2-dimethylpropane-1,3-diamine either with S- (1a) or R-methyl-2-chloropropanoate (1b) were performed to produce compounds R,R- (2a) or S,S -isomer (2b) derivatives protected with benzylchloroformate (Cbz), respectively. And then Weinreb amide and methylation reaction using Grignard reagent, oxime formation with ketone group and deprotectiion of Cbz group by hydrogenolysis gave S,S- (7a) or R,R-HMPAO (7b), respectively. Entaniomeric compounds were synthesied with high yield and purity without any undesired product. The 7a or 7b kits containing 10 µg SnCl2-2H2O were labeled with 99mTc with high radiolabeling yield (90%).
Building a text collection for Urdu information retrieval
Rasheed, Imran,Banka, Haider,Khan, Hamaid M. Electronics and Telecommunications Research Instit 2021 ETRI Journal Vol.43 No.5
Urdu is a widely spoken language in the Indian subcontinent with over 300 million speakers worldwide. However, linguistic advancements in Urdu are rare compared to those in other European and Asian languages. Therefore, by following Text Retrieval Conference standards, we attempted to construct an extensive text collection of 85 304 documents from diverse categories covering over 52 topics with relevance judgment sets at 100 pool depth. We also present several applications to demonstrate the effectiveness of our collection. Although this collection is primarily intended for text retrieval, it can also be used for named entity recognition, text summarization, and other linguistic applications with suitable modifications. Ours is the most extensive existing collection for the Urdu language, and it will be freely available for future research and academic education.
<sup>188</sup>Re Labeled liver therapeutic drugs for hepatic carcinoma (HCC)
Seelam, Sudhakara Reddy,Banka, Vinay Kumar,Lee, Yun-Sang,Jeong, Jae Min Korean Society of Radiopharmaceuticals and Molecul 2019 Journal of radiopharmaceuticals and molecular prob Vol.5 No.1
$^{188}Re$ is one of the most readily available generator derived and useful radionuclides for therapy emitting ${\beta}^-$ particles (2.12 MeV, 71.1% and 1.965 MeV, 25.6%) and imageable gammas (155 keV, 15.1%). The $^{188}W/^{188}Re$ generator is an ideal source for the long term (4-6 months) continuous availability of no carrier added (NCA) $^{188}Re$ suitable for the preparation of radiopharmaceuticals for radionuclide therapy. Rhenium-188 has been used for the preparation of therapeutic radiopharmaceuticals for the management of diseases such as bone metastasis, rheumatoid arthritis and primary cancers. Several early phase clinical studies using radiopharmaceuticals based on $^{188}Re$ -labeled phosphonates, antibodies, peptides, lipiodol and particulates have been reported. In this review, we addressed the current development status of $^{188}Re$ radiopharmaceuticals for liver cancer therapy and their applications.
Shinto, Ajit S,Indira, VU,Kamaleshwaran, KK,Banka, Vinay Kumar,Aswathy, KK,Thirumalaisamy, SG,Rajamani, V,Mallia, Madhav,Banerjee, Sharmila Korean Society of Radiopharmaceuticals and Molecul 2015 Journal of radiopharmaceuticals and molecular prob Vol.1 No.2
Radiation synovectomy has been proposed as a promising palliative therapy for recurrent joint effusions for the last two or three decades. Ionizing radiations emitted by intrarticularly administered radiolabelled colloids. The aim of this study was to assess the effectiveness of radiation synovectomy (RSV) using $^{188}Re$-tin colloid in the treatment of recurrent joint effusions and chronic synovitis of knee joints. Three phase bone scan was acquired for the concerned joint prior to radiosynovectomy. $^{188}Re$-tin colloid was prepared as per the reported protocol. 9 patients, diagnosed with rheumatoid arthritis and suffering from chronic resistant synovitis of the knee, ankle or elbow joints were administered the radiopharmaceuticals, checked for radiochemical purity >95% by intraarticular route. A whole body scan was acquired 2 h post-radiosynovectomy. In all the 9 treatments, no leakage to non-target organs was visible in the whole body scan. Static scans of the joint revealed complete retention of $^{188}Re$-tin colloid in the joints post administration of the agent. Clinically all patients exhibited a complete or partial response. RSV with $^{188}Re$-tin colloid was safe and effective in patients with chronic synovitis of rheumatoid origin.
188Re Labeled liver therapeutic drugs for hepatic carcinoma (HCC)
Sudhakara Reddy Seelam,Yun Sang Lee,Vinay Kumar Banka,Jae Min Jeong 대한방사성의약품학회 2019 Journal of radiopharmaceuticals and molecular prob Vol.5 No.1
188Re is one of the most readily available generator derived and useful radionuclides for therapy emitting βˉparticles (2.12 MeV, 71.1% and 1.965 MeV, 25.6%) and imageable gammas (155 keV, 15.1%). The 188W/188Regenerator is an ideal source for the long term (4-6 months) continuous availability of no carrier added (NCA) 188Resuitable for the preparation of radiopharmaceuticals for radionuclide therapy. Rhenium-188 has been used forthe preparation of therapeutic radiopharmaceuticals for the management of diseases such as bone metastasis,rheumatoid arthritis and primary cancers. Several early phase clinical studies using radiopharmaceuticalsbased on 188Re -labeled phosphonates, antibodies, peptides, lipiodol and particulates have been reported. In this review, we addressed the current development status of 188Re radiopharmaceuticals for liver cancertherapy and their applications.
Ajit S Shinto,Indira VU,Kamaleshwaran KK,Vinay Kumar Banka,Aswathy KK,Thirumalaisamy SG,Rajamani V,Madhav Mallia,Sharmila Banerjee 대한방사성의약품학회 2015 Journal of radiopharmaceuticals and molecular prob Vol.1 No.2
Radiation synovectomy has been proposed as a promising palliative therapy for recurrent joint effusions for the last two or three decades. Ionizing radiations emitted by intrarticularly administered radiolabelled colloids. The aim of this study was to assess the effectiveness of radiation synovectomy (RSV) using 188Re-tin colloid in the treatment of recurrent joint effusions and chronic synovitis of knee joints. Three phase bone scan was acquired for the concerned joint prior to radiosynovectomy. 188Re-tin colloid was prepared as per the reported protocol. 9 patients, diagnosed with rheumatoid arthritis and suffering from chronic resistant synovitis of the knee, ankle or elbow joints were administered the radiopharmaceuticals, checked for radiochemical purity >95% by intraarticular route. A whole body scan was acquired 2 h post-radiosynovectomy. In all the 9 treatments, no leakage to non-target organs was visible in the whole body scan. Static scans of the joint revealed complete retention of 188Re-tin colloid in the joints post administration of the agent. Clinically all patients exhibited a complete or partial response. RSV with 188Re-tin colloid was safe and effective in patients with chronic synovitis of rheumatoid origin. J Radiopharm Mol Probes 1(2):109-117, 2015
Comparison of Time Taken in Conventional versus Active Robotic-Assisted Total Knee Arthroplasty
Sanjay Bhalchandra Londhe,Santosh Shetty,Vijay Shetty,Clevio Desouza,Paras Banka,Nicholas Antao 대한정형외과학회 2024 Clinics in Orthopedic Surgery Vol.16 No.2
Background: Computer- and robotic-assisted total knee replacement procedures have been shown to improve the accuracy of the implant size. It also allows dynamic confirmation of the implant and limb alignment during total knee arthroplasty (TKA). The major inhibition of the arthroplasty surgeon in adapting to the robotic-assisted TKA (RA-TKA) is the extra time spent during the registration process and milling of the bone with the robot. The aim of the study was to ascertain the extra time spent during these 2 steps as compared to the conventional TKA (C-TKA). Methods: It is a prospective study involving 30 patients each in the conventional TKA and RA-TKA operated by the same surgical team. The patients were given a choice between the C-TKA and RA-TKA and consecutive 30 cases in each group were studied by an independent observer. In the C-TKA group, the time for the application of appropriate zigs and execution of the bone cuts and soft-tissue release was recorded whereas in the RA-TKA group, the time taken for fixation of the tibial and femoral arrays and bone registration and bone milling with robot and required soft-tissue release was measured. Results: The preoperative patient characteristics were the same in both groups. The time taken in the C-TKA and RA-TKA groups was 24.77 ± 1.92 minutes and 25.03 ± 3.27 minutes, respectively, which is statistically insignificant (p = 0.709). Conclusions: The study findings show that RA-TKA does not take additional time than C-TKA.