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Fernandez, Maria Elena,Goszczynski, Daniel Estanislao,Prando, Alberto Jose,Peral-Garcia, Pilar,Baldo, Andres,Giovambattista, Guillermo,Liron, Juan Pedro Korean Society of Animal Sciences and Technology 2014 한국축산학회지 Vol.56 No.5
Puberty is a stage of sexual development determined by the interaction of many loci and environmental factors. Identification of genes contributing to genetic variation in this character can assist with selection for early pubertal bulls, improving genetic progress in livestock breeding. Thyroid hormones play an important role in sexual development and spermatogenic function. The objective of this study was to evaluate the association between single nucleotide polymorphisms (SNPs) located in thyroglobulin(TG) gene with age of puberty in Angus bulls. Four SNPs were genotyped in 273 animals using SEQUENOM technology and the association between markers and puberty age was analyzed. Results showed a significant association (P < 0.05) between these markers and puberty age estimated at a sperm concentration of 50 million and a progressive motility of 10%. This is the first report of an association of TG polymorphisms with age of puberty in bulls, and results suggest the importance of thyroidal regulation in bovine sexual development and arrival to puberty.
( Paolo Allasia ),( Giorgio Lollino ),( Daniele Giordan ),( Danilo Godone ),( Aleksandra Wrzesniak ),( Marco Baldo ) 대한지질공학회 2019 대한지질공학회 학술발표회논문집 Vol.2019 No.2
In the field of geohazards, the monitoring networks are often used to control and manage phenomena related to the engineering geology environment. Recently, the development of technologies to measure surface displacement has been observed, especially remote sensing techniques. However, the measurement of superficial displacement does not always fully describe the kinematic of the phenomena. Sometimes, the surface measurements represent a sum of deformations developed in the subsoil at different depths and with a complex distribution that can change also with time. In this field, we developed a robotized monitoring system to measure horizontal deep-seated ground deformations in a borehole. This instrument performs automatically inclinometric measurements (many per day), using standard approach (double readings 0/180°) for all the lengths of the borehole (up to 120 meters) using a single inclinometric probe. This system was extensively installed within landslide monitoring networks in the Alps. It allowed obtaining the results in terms of: i) the definition of the deep and surface kinematics of the observed phenomena ii) the evaluation of the displacement accelerations iii) the relationship between rainfalls/snow melting and water table levels.Recently, our system was installed in the geotechnical context to monitor the relationship between excavations with TBM and deep-seated ground deformation measurements. The elements at risk were Italian architectural heritages like the Roman Colosseum and the Basilica of St. Stephen. The main goals of this application was to compare the expected and designed deep-seated ground deformations and to monitor the potential interaction between subsoil deformations and historical monuments on the ground.
Measurement of the neutrino velocity with the ICARUS detector at the CNGS beam
ICARUS Collaboration,Antonello, M.,Aprili, P.,Baiboussinov, B.,Baldo Ceolin, M.,Benetti, P.,Calligarich, E.,Canci, N.,Centro, S.,Cesana, A.,Cieslik, K.,Cline, D.B.,Cocco, A.G.,Dabrowska, A.,Dequal, D. North-Holland Pub. Co 2012 Physics letters: B Vol.713 No.1
At the end of the 2011 run, the CERN CNGS neutrino beam has been briefly operated in lower intensity mode with ∼10<SUP>12</SUP> p.o.t./pulse and with a proton beam structure made of four LHC-like extractions, each with a narrow width of ∼3 ns, separated by 524 ns. This very tightly bunched beam allowed a very accurate time-of-flight measurement of neutrinos from CERN to LNGS on an event-by-event basis. The ICARUS T600 detector (CNGS2) has collected 7 beam-associated events, consistent with the CNGS collected neutrino flux of 2.2x10<SUP>16</SUP> p.o.t. and in agreement with the well-known characteristics of neutrino events in the LAr-TPC. The time of flight difference between the speed of light and the arriving neutrino LAr-TPC events has been analysed. The result δt=0.3+/-4.9(stat.)+/-9.0(syst.) ns is compatible with the simultaneous arrival of all events with speed equal to that of light. This is in a striking difference with the reported result of OPERA (OPERA Collaboration, 2011) [1] claiming that high energy neutrinos from CERN arrive at LNGS ∼60 ns earlier than expected from luminal speed.
( Maria Elena Fernandez ),( Daniel Estanislao Goszczynski ),( Alberto Jose Prando ),( Pilar Peral Garcia ),( Andres Baldo ),( Guillermo Giovambattista ),( Juan Pedro Liron ) 한국동물자원과학회(구 한국축산학회) 2014 한국축산학회지 Vol.56 No.17
Puberty is a stage of sexual development determined by the interaction of many loci and environmental factors. Identification of genes contributing to genetic variation in this character can assist with selection for early pubertalbulls, improving genetic progress in livestock breeding. Thyroid hormones play an important role in sexualdevelopment and spermatogenic function. The objective of this study was to evaluate the association betweensingle nucleotide polymorphisms (SNPs) located in thyroglobulin(TG) gene with age of puberty in Angus bulls. FourSNPs were genotyped in 273 animals using SEQUENOM technology and the association between markers andpuberty age was analyzed. Results showed a significant association (P < 0.05) between these markers and pubertyage estimated at a sperm concentration of 50 million and a progressive motility of 10%. This is the first report of anassociation of TG polymorphisms with age of puberty in bulls, and results suggest the importance of thyroidalregulation in bovine sexual development and arrival to puberty.
BGN Mutations in X-Linked Spondyloepimetaphyseal Dysplasia
Cho, S.Y.,Bae, J.S.,Kim, N.K.D.,Forzano, F.,Girisha, K.M.,Baldo, C.,Faravelli, F.,Cho, T.J.,Kim, D.,Lee, K.Y.,Ikegawa, S.,Shim, J.S.,Ko, A.R.,Miyake, N.,Nishimura, G.,Superti-Furga, A.,Spranger, J.,Ki University of Chicago Press [etc.] 2016 American journal of human genetics Vol.98 No.6
<P>Spondyloepimetaphyseal dysplasias (SEMDs) comprise a heterogeneous group of autosomal-dominant and autosomal-recessive disorders. An apparent X-linked recessive (XLR) form of SEMD in a single Italian family was previously reported. We have been able to restudy this family together with a second family from Korea by segregating a severe SEMD in an X-linked pattern. Exome sequencing showed missense mutations in BGN c.439A>G (p.Lys147Glu) in the Korean family and c.776G>T (p.Gly259Val) in the Italian family; the c.439A>G (p.Lys147Glu) mutation was also identified in a further simplex SEMD case from India. Biglycan is an extracellular matrix proteoglycan that can bind transforming growth factor beta (TGF-beta) and thus regulate its free concentration. In 3-dimensional simulation, both altered residues localized to the concave arc of leucine-rich repeat domains of biglycan that interact with TGF-beta. The observation of recurrent BGN mutations in XLR SEMD individuals from different ethnic backgrounds allows us to define 'XLR SEMD, BGN type'' as a nosologic entity.</P>
Irradiation-induced disordering and amorphization of Al<sub>3</sub>Ti-based intermetallic compounds
Park, Jeong-Yong,Kim, Il-Hyun,Motta, Arthur T.,Ulmer, Christopher J.,Kirk Jr., Marquis A.,Ryan Jr., Edward A.,Baldo Jr., Peter M. Elsevier 2015 JOURNAL OF NUCLEAR MATERIALS Vol.467 No.2
<P><B>Abstract</B></P> <P>An in situ ion-irradiation study, simultaneously examined using transmission electron microscopy, was performed to investigate irradiation-induced disordering and amorphization of Al<SUB>3</SUB>Ti-based intermetallic compounds. Thin foil samples of two crystalline structures: D0<SUB>22</SUB>-structured Al<SUB>3</SUB>Ti and L1<SUB>2</SUB>-structured (Al,Cr)<SUB>3</SUB>Ti were irradiated using 1.0 MeV Kr ions at a temperature range from 40 K to 573 K to doses up to 4.06 × 10<SUP>15</SUP> ions/cm<SUP>2</SUP>. The results showed that both the compounds underwent an order-disorder transformation under irradiation, where both Al<SUB>3</SUB>Ti and (Al,Cr)<SUB>3</SUB>Ti ordered structures were fully transformed to the disordered face-centered cubic (FCC) structure except at the highest irradiation temperature of 573 K. A slightly higher irradiation dose was required for order-disorder transformation in case of Al<SUB>3</SUB>Ti as compared to (Al,Cr)<SUB>3</SUB>Ti at a given temperature. However, their amorphization resistances were different: while the disordered FCC (Al,Cr)<SUB>3</SUB>Ti amorphized at the irradiation dose of 6.25 × 10<SUP>14</SUP> ions/cm<SUP>2</SUP> (0.92 dpa) at 40 K and 100 K, the Al<SUB>3</SUB>Ti compound with the same disordered FCC structure maintained crystallinity up to 4.06 × 10<SUP>15</SUP> ions/cm<SUP>2</SUP> (5.62 dpa) at 40 K. The critical temperature for amorphization of (Al,Cr)<SUB>3</SUB>Ti under Kr ion irradiation is likely between 100 K and room temperature and the critical temperature for disordering between room temperature and 573 K.</P>