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      • Interferon-γ and Interleukin-10 Gene Polymorphisms are not Predictors of Chronic Hepatitis C (Genotype-4) Disease Progression

        Bahgat, Nermine Ahmed,Kamal, Manal Mohamed,Abdelaziz, Ashraf Omar,Mohye, Mohamed Ahmed,Shousha, Hend Ibrahim,ahmed, Mae Mohamed,Elbaz, Tamer Mahmoud,Nabil, Mohamed Mahmoud Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.12

        Immunoregulatory cytokines have an influence on hepatitis C virus (HCV) infection outcome. This study aimed to determine whether single nucleotide polymorphisms (SNP) in IFN- ${\gamma}$ and IL-10 genes are associated with susceptibility and/or are markers of prognosis regarding chronic hepatitis C outcomes. IFN ${\gamma}$ (+874T/A) and IL-10 (-1082G/A) genotypes were determined in 75 HCV genotype 4 patients with different disease severities (chronic hepatitis, n=25, liver cirrhosis and hepatocellular carcinoma (HCC) on top of liver cirrhosis, n=50) and 25 healthy participants using allele-specific polymerase chain reaction. No statistical differences in allele or genotype distributions of IFN ${\gamma}$ and IL-10 genes were detected between patients and controls or between patientgroups. No significant difference in the frequency of IL-10 SNP at position -1082 or IFN-${\gamma}$ at position +874T/A was found between chronic HCV genotype 4 and with progression of disease severity in liver cirrhosis or HCC. In conclusion; interferon-${\gamma}$ and interleukin-10 gene polymorphisms are not predictors of disease progression in patients with chronic hepatitis C (Genotype-4).

      • RECK Gene Promoter rs10814325 Polymorphism in Egyptian Patients with Hepatocellular Carcinoma on Top of Chronic Hepatitis C Viral Infection

        Fakhry, Amal Bahgat,Ahmed, Asmaa Ismail,AbdelAlim, Mahmoud Abdo,Ramadan, Dalia Ibrahim Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.5

        Background: The reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) gene is a novel transformation suppressor gene linked to several malignancies. Objective: To analyze any association between RECK gene rs10814325 single-nucleotide polymorphism (SNP) and HCC susceptibility with various clinicopathological and laboratory data. Materials and Methods: RECK gene rs10814325 SNP was estimated, using real-time PCR, in 30 HCC patients on top of HCV infection, 30 HCV related cirrhotic patients and 30 healthy controls. Results: No special pattern of association could be detected on comparing the RECK gene rs10814325 genotypes(P=0.5), or alleles(P=0.49) among the studied groups. HCC patients with TT genotype had younger age (mean of $54.1{\pm}6.0$ years vs $60.6{\pm}10.2$ years for TC/CC genotypes, P=0.035). Abdominal distension was significantly greater in TT genotype patients (75% vs 30%for TC/CC genotypes, P=0.045). The TT genotype was present in 75% of patients with lymph node metastasis. Serum GGT levels were higher in TT genotype patients [80 (48.5-134.8) IU/L vs 40 (33-87.5) IU/L for TC/CCgenotypes], and lower limb edema was observed in 60% for TT vs 20% for TC/CCgenotypes, but both just failed to reach significance (p=0.05 and p=0.06 respectively). Conclusions: RECK gene rs10814325 T>C could not be considered a risk factor for HCC development on top of HCV, but may be related to the disease progression and metastasis.

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        Nonlinear Observers for Spacecraft Attitude Estimation in Case of Yaw Angle Measurement Absence

        Mohamed M. Aly,Hossam A. Abdel Fatah,Ahmed Bahgat 제어·로봇·시스템학회 2010 International Journal of Control, Automation, and Vol.8 No.5

        This paper provides a brief presentation and a useful comparison between two nonlinear observers Extended Kalman Filter (EKF) and sliding mode observer (SMO). Both can be used for moderate-accuracy attitude determination systems for Low Earth Orbit (LEO) Earth-pointing spacecraft (s/c), which is typically achieved using Gyroscopes, Earth, and Sun sensors for attitude sensing. The use of these observers provides a substitute for the yaw data in case of the s/c eclipse periods or limited field of views. The nonlinear observability for this system is analytically investigated via the calculation of Lie derivatives to check the possibility of the system states estimation. The performances of both observers are presented, the SMO stability is proved and the SMO enhanced estimates are shown by simulation.

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        Micro-grid Monitoring and Supervision: Web-based SCADA Approach

        Ali Mohamed A.,Barakat Mahmoud M.,Abokhalaf Masoud M.,Fadel Yasmin H.,Kandil Mohamed,Rasmy Mariam W.,Ali Osama N.,Besheer Ahmad H.,Emara Hassan M.,Bahgat Ahmed 대한전기학회 2021 Journal of Electrical Engineering & Technology Vol.16 No.5

        Owing to the widespread use of the micro-grid concept to serve many real life applications, the main concern of this paper is to monitor, evaluate and manage the operational performance of an existent, already installed micro-grid that consists of On & Off grid PV systems in addition to the main grid supply. With the aid of customized web based SCADA system fully designed by authors, the performance evaluation of the proposed micro-grid is carried out in terms of energy consumption, power quality indices and energy cost based on Egypt’s energy current tariff . The designed system helps in both micro-grid status monitoring as well as load sharing between the main grid supply and the off grid PV energy system. The data of the on grid PV energy system are accessed and collected online directly from the inverter web server instead of downloading them offl ine from the PV inverter. In this case, data are analyzed with a reasonable refresh rate, which saves time and eff ort. Remote access platform is developed securely through a multi-level security authentication and strong data encryption using the OpenVPN protocol under the Dynamic Domain Name System service. Smart wired and wireless technology—used as integrated sensing devices to the developed SCADA system—enables easy system installation and running cost saving. Finally, to validate the collected data from the newly SCADA designed monitoring system, a performance characterization for the on grid PV system following international standards of yields calculations is carried out for 3 months in 2019.

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