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RISS 인기검색어
- 검색키워드
- 저자 : Bahat, Zumrut (검색결과 3 건)
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Kandaz, Mustafa,Soydemir, Gulsen,Bahat, Zumrut,Canyilmaz, Emine,Yoney, Adnan Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.3
Purpose: To review clinical characteristics, treatment outcomes and prognostic factors in patients with parotid gland tumors treated with surgery and postoperative radiotherapy. Materials and Methods: We retrospectively reviewed 69 patients with parotid gland tumors, with a median follow-up of 52 months (range, 2-228 months). and a median radiotherapy dose of 60Gy (range, 30-69 Gy). Results: There were 24 (35%) females and 45 (65%) males, at a ratio of 1/1.9. Median age at presentation was $58.9{\pm}17.2$ (range 13-88) years. The most common histology was adenoid cystic carcinoma (33%) and mucoepidermoid carcinoma (28%). The mean overall survival (OS) was $65.3{\pm}8$ (95% confidence interval [CI], 49.6-81.1) months and the median overall survival was $40.0{\pm}7$ (95% CI, 26.2-53.7) months. The -1, -3, -5 and -10 year OS rates were 78%, 52.4%, 35.3% and 19.6% respectively. The mean disease free survival (DFS) was $79.2{\pm}10$ (95% CI, 59.3-97.1) months and the median disease free survival was $38{\pm}13$ (95% CI, 7.05-88.7) months. The -1,-3,-5 and -10 year DFS rates were 71.9%, 50.1%, 43.7% and 30.1% respectively. On univariate analysis, the OS was significantly better with female sex (p<0.005), < 50 age (p<0.021), T stage (p<0.0001), absence of lymph node involvement (p<0.0001), lower tumor grade (p<0.0001), absence of lymphovascular invasion (p<0.002), absence of perineural invasion (p<0.0001), absence of extracapsuler extension (p<0.0001), surgical margin negativity (p<0.006), ${\leq}60Gy$ radiotherapy dose (p<0.0001) and absence of distant metastasis (p<0.027). Conclusions: Employing existing standards of postoperative radiotherapy is a possible treatment that was found to be mainly effective in patients with parotid gland carcinomas.
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Evaluation of Prognostic Factors and Survival Results in Pancreatic Carcinomas in Turkey
Canyilmaz, Emine,Serdar, Lasif,Uslu, Gonca Hanedan,Soydemir, Gulsen,Bahat, Zumrut,Yoney, Adnan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11
Background: The goal of this retrospective study was to evaluate patient characteristics, treatment modalities and prognostic factors in Turkish patients with pancreatic cancer. Materials and Methods: Between January 1997 and December 2012, 64 patients who presented to the Department of Radiation Oncology, Karadeniz Technical University, Faculty of Medicine with a diagnosis of pancreatic cancer were evaluated. The E/K ratio of the cases was 2.4/1 and the median age was 59.6 (32-80) years, respectively. Some 11 cases (18%) were stage 1, 21 (34.4%) were stage 2, 10 (16.4%) were stage 3, and 19 (31.1%) were metastatic. Results: The mean follow-up time was 15.7 months (0.7-117.5) and loco-regional recurrence was noted in 11 (40.7%) who underwent surgery while metastases were observed in 41 patients (66.1%). The median overall survival (OS) was 11.2 months and the 1, 3 and 5-year OS rates were 41.7%, 9.9% and 7.9% respectively. The median disease-free survival (DFS) was 5.2 month and the1, 2 and 5 year DFS were 22.6%, 7.6% and 3.8% respectively. On univariate analysis, prognostic factors affecting OS included status of the operation (p<0.001), tumor stage (p=0.008), ECOG performance status (p=0.005) and CEA level (p=0.017).On multivariate analysis, prognostic factors affecting survival included status of the operation (p=0.033) and age (p= 0.023). Conclusions: In the current study, age and operation status were independent prognostic factors for overall survival with pancreatic patients. Thus, the patients early diagnosis and treatment ars essential. However, prospective studies with more patients are needed for confirmation.
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Onychomycosis Caused by Aspergillus in a Patient with Leprosy: A Case Report
Andrea Hertanto,Muhammad Yulianto Listiawan,Evy Ervianti,Afif Nurul Hidayati,Trisiswati Indranarum,Sunarso Suyoso,Linda Astari,Sylvia Anggraeni,Yuri Widia,Azalia Aprinda Bahat,Fitra Tri Kurniasari 대한의진균학회 2024 대한의진균학회지 Vol.29 No.1
Aspergillus spp., one of the most common nondermatophyte molds (NDMs) that cause onychomycosis, are saprophytic fungi that can act as zoonotic agents and cause various health issues, including onychomycosis, in humans. Predisposing factors for onychomycosis include nail trauma, immunosuppression, and occupation. Nails in patients with leprosy are prone to change and develop onychomycosis due to unrecognized trauma to the nail area. Here, we report the case of a 25-year-old woman with 2-month history of white patches in fingernails and toenails, which were also brittle and damaged. She was a veterinarian who had frequent, direct interaction with animals, particularly dogs and cats. She denied trauma prior to the manifestation of symptoms and was undergoing leprosy treatment, including corticosteroids for leprosy reactions. Examination with potassium hydroxide revealed hyphae, and the nail culture revealed growth of fungal colonies with the characteristics of A. flavus. She received four cycles of itraconazole at 400 mg/day. Two of the three afflicted nails showed complete cure, whereas one nail showed mycologic cure. A. flavus is frequently found in animals, including dogs and cats and might have been a source of Aspergillus transmission, suggesting the patient's occupation and immunosuppression as risk factors for onychomycosis. Onychomycosis due to Aspergillus, particularly A. flavus, responds well to itraconazole pulse monotherapy.
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