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주지현,최정현,이동건,백지연,고윤호,이혜정,김세희,신호진,박윤희,박지영,김유진,신완식,김춘추 대한감염학회 2001 감염 Vol.33 No.4
Background : Pneumocytitis cainii pneumonia (PCP) can occur in immunocompromised hosts especially such as AIDS or cancer patients. Although recent research had focused on PCP in AIDS patients, few studies have described the clinical presentations of PCP in recipients of stem cell transplantation (SCT). We evaluated the clinical manifestations of PCP in SCT patients admitted at St. Mary's hospital, Seoul, Korea. Methods : The medical records of 17 PCP patients undergoing SCT between Feb. 1998 and Feb. 2000 were reviewed. The diagnosis of PCP was confirmed through the demonstration of Pneumocytitis cainii via either cytology of brochoalveolar lavage (BAL) or histological technique of lung biopsy. CMV disease and CMV infection were confirmed by BAL culture and antigenemia respectively . Results : Seventeen patients were all recipients of allogeneic SCT and 7 of 17 patients were performed non-sibling SCT. Patients presented with symptoms including brief period (4 ∼23 days) of fever (76%), dyspnea (70%), cough (64%), and signs such as rare(58.8%), Sixteen patients (94%) had been receiving immunosuppressive agent such as cyclosporine A (64%) or Fk506 (35%) without PCP prophylaxis. Eleven patients (64%) were treated with corticosteroid with mean dose of 16 mg/day prednisolone and mean duration of 4.6 months after post-SCT period. Twelve patients were co-infected with CMV. Another co-infected miCroorganisms were Pseudomonas aeruginosa, Mycobacterium tuberculosis, herpes simplex virus, parainfluenza virus, Average duration of treatment with trimethoprim-sulfamethoxazole (TMP/SMX) was 21 ±9 days. Four patients died, and three of them were related with PCP. Conclusion : PCP developed frequently in patients who were taking immunosuppressive drug due to graft versus host disease or were not taking TMP/SMX prophylaxis. High risk patients showing fever, cough, or dyspnea should be considered to take early bronchoscopic intervention for detection of PCP. When treat for PCP, it also be considered to the possibility of coinfection such as CMV. (Korean J Infect Dis 33:273∼279, 2001)
Yun-Ju Baek,Bok-Rye Lee,Seung Gon Wi,Ung Yang,Sang-Hyun Lee 한국원예학회 2021 한국원예학회 학술발표요지 Vol.2021 No.10
Reactive oxygen species (ROS) acts as signaling molecule in regulation of fruit growth and development. It is related to modulation of the balance between cell wall loosening and stiffening. This study was performed to investigate the relationship between fruit size and ROS in three Asian pear cultivars having different harvest period during fruit growth and development. Three Asian pear cultivars, ‘Wonhwang’ (early-maturity), ‘Whangkeumbae’ (early-maturity), and ‘Niitaka’ (late-maturity), were selected. The final fruit fresh weight was higher in the late-maturing cultivar ‘Niitaka’ than in the early-maturing cultivars ‘Wonhwang’ and ‘Whangkeumbae’. Lignin content was gradually decreased as fruit matured and started to decrease at 57 days after full bloom (DAFB) in ‘Wonhwang’ and ‘Whangkeumbae’ and 87 DAFB in ‘Niitaka’. Superoxide anion (O₂<SUP>-</SUP>) content in three pear cultivars was rapidly decreased from 87 DAFB to 117 DAFB and its decrease rate was higher in ‘Whwangkeumbae’ and ‘Niitaka’ than that in ‘Wonhwang’. Hydrogen peroxide (H₂O₂) contents in ‘Wonhwang’ and ‘Whangkeumbae’ were remarkedly decreased by 80% of initial level at 72 DAFB, whereas its content in ‘Niitaka’ was maintained to initial level until 87 DAFB and then decreased to the end of harvest. Similar tendency was observed in superoxide dismutase (SOD) activity. The ‘Niitaka’ showed the highest SOD activity. Guaiacol peroxidase (GPOD) and Coniferyl alcohol (CPOD) activity significantly decreased after 87 DAFB in three Asian pear cultivars. Their activities were higher in ‘Niitaka’ than in ‘‘Wonhwang’ and ‘Whangkeumbae’ during fruit growth and development. These results indicate that fruit size may be affected by ROS content in the early stage of fruit growth and development.