상안검거근 절제술과 전두근 전이술을 이용한 안검하수증의 수술결과

박배근,김정헌,김동철 大韓成形外科學會 1994 Archives of Plastic Surgery Vol.21 No.5

The blepharoptosis is the disease which is caused by the congenital or acquired weakness of the levator palpebrae superioris. From September 1984 to December 1992, authors had treated 19 blepharoptosis patients(22 cases of operation), and the operative procedures were chosen according to the patient's levator function : levator resection in cases with levator function above 4mm(6 cases), frontalis transfer in cases with levator function below 2mm(5cases), levator resection(7cases) or frontalis transfer(4 cases) in cases with levator function between 2-4mm. And the operative results were evaluated with the average follow up period of 34.5 months. The results were summarized as follows. 1. 15patients were congenital and 4 patients were acquired type of blepharoptosis and sex ratio was 11:4(male:female) in 15 congenital blepharoptosis patients. 2. We performed 13 cases of levator resection and 9 cases of frontalis transfer. 3. In cases of moderate blepharoptosis, whose levator function is 4-8mm or 2-4mm, results of levator resection and the frontalis transfer are both good. 4. In cases of severe blepharoptosis, whose levator function is 2-4mm, result of levator resection is relatively fair, the frontalis transfer is good. 5. Results of frontalis transfer in acquired type showed excellent regardless of levator function. 6. The incidence of undercorrection after levator resection in congenital blepharoptosis was 72.7%, and the frontalis transfer showed frequent severe complication such as persistent lagophthalmos, exposure keratitis, hollowness of temporal area, headache, overcorrection & undercorrection.

미세혈관 문합술을 이용한 절단된 귀 재접합 치험례:1례보고

김정헌,이현택,박배근,김동철,황성진 대한성형외과학회 1992 Archives of Plastic Surgery Vol.19 No.3

The auricle is frequently exposed to trauma due to its protruding anatomical position and it is sometimes severed completely. Many kinds of techniques such as composite graft or cartilage preservation methods for the reattachment or reconstruction of and amputated ear have been tried. But their indications are limited and results are not satisfactory. For the complete survival of ear cartilage and skin of the amputated part, microvascular replantation is known as the best procedure. But cases of successful replantations have been rare until now, because of technical difficulties due to the small size of auricular vessels and uncertain vascular anatomy. In 1980, Pennington et al. reported the first successful microvasclar replantation of a totally avulsed ear using vein graft. After that about 10 cases of world wide successful micro replantation of servered ears were reported. Here, we report a case of a successful replantation of a completely amputated lower half of auricle including the ear lobule due to a human bite. Replantation was done by direct anastomosis of transected peripheral branches of the posterior auricular artery and vein without vein graft. We again emphasize that, in spite of the technical difficulties and long operative time, successful replantation of an amputated ear with microvascular surgery is superior to any other methods of reattachment or reconstruction.

Apoptotic cell death of human leukaemia U937 cells by ubiquinone-9 purified from Pleurotus eryngii

Bae, Jeen-Soo,Park, Jin Wook,Park, So Hyun,Park, Jung Bin,Rho, Yoon-Hwa,Ryu, Young Bae,Lee, Kun-Sik,Park, Ki-Hun,Bae, Young-Seuk Taylor Francis 2009 NATURAL PRODUCT RESEARCH Vol.23 No.12

<P> A chloroform extract of the edible mushroom Pleurotus eryngii showed an inhibitory effect on mammalian DNA topoisomerase I. The topoisomerase I inhibitory compound was purified and identified as ubiquinone-9. Ubiquinone-9 was shown to inhibit the activity of topoisomerase I with IC50 of about 50 µM. Concentration of 110 µM ubiquinone-9 caused 50% growth inhibition of human leukaemia U937 cells, but not that of normal fibroblast NIH3T3 and 3Y1 cells. Ubiquinone-9-induced cell death was characterised with the cleavage of poly (ADP-ribose) polymerase and pro-caspase 3. Furthermore, ubiquinone-9 induced the fragmentation of DNA into an apoptotic DNA ladder, indicating that the inhibitor triggered apoptosis. The induction of apoptosis by ubiquinone-9 was also confirmed using flow cytometry analysis. Taken together, these results suggest that ubiquinone-9 may function by inhibiting oncogenic disease, at least in part, through the inhibition of topoisomerase I activity.</P>

ON WALLMAN-TYPE EXTENSIONS

Park, Bae-Hun Department of Mathematics 1979 Kyungpook mathematical journal Vol.19 No.2

Fuzzy convergence structures

Park,Bae-Hun,Park,Jin-Han,Lee,Bu-Young 東亞大學校附設基礎科學硏究所 1993 基礎科學硏究論文集 Vol.10 No.1

We define a fuzzy convergence structure which is a correspondence between the prefilters on a given set X and the fuzzy subsets of X. The notion of fuzzy convergence structure is shown to be a generalization of a fuzzy topology.

Effectiveness and Safety of Biolimus A9™-Eluting stEnt in Patients with AcUTe Coronary sYndrome; A Multicenter, Observational Study (BEAUTY Study)

Park, Keun-Ho,Jeong, Myung Ho,Hong, Young Joon,Ahn, Youngkeun,Kim, Hyun Kuk,Koh, Young Yub,Kim, Doo Il,Kim, Sang Wook,Kim, Weon,Rha, Seung Woon,Rhew, Jay Young,Park, Jong Seon,Park, Hun Sik,Bae, Jang Yonsei University, College of Medicine 2018 Yonsei medical journal Vol.59 No.1

<P><B>Purpose</B></P><P>This study sought to determine the 1-year clinical effectiveness and safety of a biodegradable, polymer-containing Biolimus A9™-eluting stent (BES) in Korean patients with acute coronary syndrome (ACS).</P><P><B>Materials and Methods</B></P><P>A total of 1000 ACS patients with 1251 lesions who underwent implantation of BESs at 22 centers in Korea were enrolled between May 2011 and July 2013. We assessed major adverse cardiac events (MACE) defined as the composite of cardiac death, non-fatal myocardial infarction (MI), and clinical-driven target vessel revascularization at 12 months.</P><P><B>Results</B></P><P>Patient mean age was 62.6±11.4 years. 72.8% of the patients were male, 28.5% had diabetes, 32.8% had multi-vessel disease (MVD), and 47.9% presented with acute MI (AMI). The mean global registry of acute coronary events risk score of all patients was 103.0±27.6. The number of stents per patient was 1.3±0.6. The incidences of MACE and definite stent thrombosis at 12 months were 3.9% and 0.2%, respectively. On multivariate Cox-regression analysis, age ≥65 years was identified as an independent predictors of 1-year MACE (hazard ratio=2.474; 95% confidence interval=1.202−5.091). Subgroup analyses revealed no significant differences in the incidence of MACE between patients with and without diabetes (4.3% vs. 3.7%, <I>p</I>=0.667), between those who presented with and without AMI (4.4% vs. 3.4%, <I>p</I>=0.403), and between those with and without MVD (4.6% vs. 3.5%, <I>p</I>=0.387).</P><P><B>Conclusion</B></P><P>Our study demonstrated excellent 1-year clinical outcomes of BES implantation in patients at low-risk for ACS.</P>

Diarylheptanoids from Alnus japonica inhibit papain-like protease of severe acute respiratory syndrome coronavirus.

Park, Ji-Young,Jeong, Hyung Jae,Kim, Jang Hoon,Kim, Young Min,Park, Su-Jin,Kim, Doman,Park, Ki Hun,Lee, Woo Song,Ryu, Young Bae Pharmaceutical Society of Japan 2012 Biological & pharmaceutical bulletin Vol.35 No.11

<P>The papain-like protease (PL(pro)), which controls replication of the severe acute respiratory syndrome coronavirus (SARS-CoV), has been identified as a potential drug target for the treatment of SARS. An intensive hunt for effective anti-SARS drugs has been undertaken by screening for natural product inhibitors that target SARS-CoV PL(pro). In this study, diarylheptanoids 1-9 were isolated from Alnus japonica, and the inhibitory activities of these compounds against PL(pro) were determined. Of the isolated diarylheptanoids, hirsutenone (2) showed the most potent PL(pro) inhibitory activity, with an inhibitory concentration (IC(50)) value of 4.1 ?M. Structure-activity analysis showed that catechol and α,β-unsaturated carbonyl moiety in the molecule were the key requirement for SARS-CoV cysteine protease inhibition.</P>

On Ordered Normal Bases and Ordered Compactifications

Park,Bae-Hun,Park,Geun-Saeng 慶尙大學校 1980 論文集 Vol.19 No.1

T₁-공간의 Wallman-type Compactification을 일반화 시킨 순서 Compactification을 취급하고 있다. 순서위상공간(X, τ, ??)의 순서 normal base의 개념을 소개하여 X가 dense embedding되는 compact 순서위상공간(β0(X), τ*, ??)을 만들었고, 순서 normal base βo을 가지고 연속순서를 가진 compact순서위상공간은 (β0(X), τ*, ??)와 iseomorphic임을 밝혔다. The purpose of this paper is to construct an ordered compactification for a topological ordered space with semicontinuous order which generalizes the Wallman-type compatification of a T₁-space. In order to do this, we introduce the concept of an ordered normal base on a topological ordered space, and obtain that for a topological ordered space (X, τ, ??) with semicontinuous order having an ordered normal base β0, there exists a compact topological ordered space (β0(X), τ*, ??) with continuous order, into which X is densely embeded. It is shown that compact topological ordered space (X, τ, ??) with a continuous order having an ordered normal base β0 is iseomorphic with (β0(X), τ*, ??). Hong [1] has introduced the concept of 0-completely regular filters on a completely regular ordered space in order to construct the ordered compactification. Moreover, in [4], Y.S. Park has introduced the concept of bifilter on a topological ordered space and constructed an ordered compactification for a convex ordered topological space with semicontinuous order. In this paper, we introduce the concept of an ordered normal base for a topological ordered space (X, τ, ??) with semicontinuous order and obtain the compact topological ordered space with continuous order which is an ordered compactification for the space (X, τ, ??). For a topological ordered space we refer to [3, 5]. we assume all our topological ordered spaces to be topological ordered space with semicontinuous order. Let β₁ and β₂ be the families of sets. Then we write β₁∪β₂={A|A∈β₁ or A∈β₂} β₁∪β₂={A∩B|A∈β₁ and B∈β₂}.

Clinical, biochemical, and genetic analysis of korean patients with pseudohypoparathyroidism type ia.

Park, Chang-Hun,Park, Hyung-Doo,Lee, Soo-Youn,Kim, Jong-Won,Sohn, Young Bae,Park, Sung Won,Jin, Dong-Kyu Institute for Clinical Science] 2010 Annals of clinical and laboratory science Vol.40 No.3

<P>Pseudohypoparathyroidism (PHP) comprises a heterogeneous group of endocrine disorders with the common feature of resistance to parathormone (PTH), manifested by hypocalcemia, hyperphosphatemia, and elevation of serum PTH despite normal renal function. Herein, the first Korean cases of PHP type Ia are reported. The two patients (6-yr-old female, 7-yr-old male) had typical signs of Albright hereditary osteodystrophy. Genomic DNA was isolated from their peripheral blood leukocytes and the GNAS gene was amplified by PCR and analysed by bidirectional sequencing including all coding exons. Two GNAS mutations were found: c.94A>T and c.344_345insT. Patient 1 had a nonsense mutation of c.94A>T (p. K32X), which has not been previously described; the mother also had c.94A>T, and it therefore was a familial mutation. Patient 2 had a known frame shift mutation for c.344_345insT (p.V117RfsX23). The family members of patient 2 had wild-type sequences. In summary, two Korean patients with PHP-Ia were confirmed by genetic analysis and a novel p.K32X product of the GNAS mutation was identified.</P>

Some Properties of Semi-closure Spaces

Park, Bae Hun,Hong, Woo Chorl 釜山大學校 師範大學 1984 교사교육연구 Vol.8 No.-

Semi-closure 구조와 Semi-nearness 구조 사이의 관계와 Semi-closure 空間의 확장 그리고 그 확장이 Semi-closure 空間으로 부터 유도되는 位相空間에 대한 확장임을 보였음.