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Bach, Long Giang,Cao, Xuan Thang,Quynh, Bui Thi Phuong,Ho, Van Thi Thanh,Lim, Kwon Taek Informa UK (TaylorFrancis) 2017 MOLECULAR CRYSTALS AND LIQUID CRYSTALS - Vol.644 No.1
<P>In this study, a facile method for synthesis of conducting polymer/inorganic oxide hybrid nanocomposites, the poly(N-vinylcar bazole)/Titanium Dioxide (PVK-g-TiO2), was successfully developed via direct facile esterification reaction under extremely mild conditions. The TiO2 nanoparticles (TiO2 NPs) were first modified by 3-glycidoxypropyl trimethoxysilane in order to prepare the epoxy groups functionalized TiO2 NPs, followed by refluxing with ethanol solution of hydrochloric acid to convert the epoxy groups into alkyl-hydroxyl units. A sufficient amount of PVK was then grafted onto the as-modified TiO2 NPs via esterification reaction between the alkyl-hydroxyl units at the nanoparticle surface and the carboxyl-terminated PVK chains. Fourier transform infrared spectroscopy, Energy dispersive X-Ray, X-ray diffraction and thermogravimetric analysis were used to study the chemical and physical properties in surface functionalities.</P>
Synthesis and biological activity of new phthalimides as potential anti-inflammatory agents
Bach, D.H.,Liu, J.Y.,Kim, W.K.,Hong, J.Y.,Park, S.H.,Kim, D.,Qin, S.N.,Luu, T.T.T.,Park, H.J.,Xu, Y.N.,Lee, S.K. Elsevier/Pergamon 2017 Bioorganic & medicinal chemistry Vol.25 No.13
The overproduction of nitric oxide (NO) plays an important role in a variety of pathophysiological processes, including inflammation. Therefore, the suppression of NO production is a promising target in the design of anti-inflammatory agents. In the present study, a series of phthalimide analogs was synthesized, and their anti-inflammatory activities were evaluated using lipopolysaccharide (LPS)-stimulated NO production in cultured murine macrophage RAW264.7 cells. A structure-activity relationship study showed that the free hydroxyl group at C-4 and C-6 and the bulkiness of the N-substituted alkyl chain are associated with biological activity. Among the series of phthalimide derivatives, compound IIh exhibited potent inhibitory activity, with an IC<SUB>50</SUB> value of 8.7@?g/mL. Further study revealed that the inhibitory activity of compound IIh was correlated with the down-regulation of the mRNA and protein expression of LPS-stimulated inducible nitric oxide synthase (iNOS). Compound IIh also suppressed the induction of the pro-inflammatory cytokines tumor necrosis factor-α and interleukin-1β in LPS-stimulated RAW 264.7 cells. The anti-inflammatory activity of compound IIh was also found to be associated with the suppression of the Toll-like receptor (TLR)4 signaling pathway by down-regulating the activation of interferon regulatory factor 3 (IRF-3) and interferon-β and signal transducer expression. These findings demonstrate that novel phthalimides might be potential candidates for the development of anti-inflammatory agents.
A facile route towards the synthesis of polystyrene/zinc oxide nanocomposites.
Bach, Long Giang,Islam, M Rafiqul,Kim, Yong Hun,Seo, Sung Deok,Park, Chan,Kim, Hyun Gyu,Lim, Kwon Taek American Scientific Publishers 2013 Journal of Nanoscience and Nanotechnology Vol.13 No.1
<P>ZnO nanoparticles were covalently wrapped by polystyrene (PS) through surface thiol-lactam initiated radical polymerization using the grafting from approach. The surface of ZnO nanoparticles was initially modified by 3-mercapto propyltrimethoxysilane to afford thiol functionalized ZnO nanoparticles (ZnO-SH). The controlled radical polymerization of styrene (St) was subsequently accomplished by using an initiating system of ZnO-SH and butyrolactam. FT-IR, XPS, XRD, TGA, DSC, TEM and DLS were employed to investigate the chemical structure, morphology, thermal properties, the size and size distribution of nanocomposites. The dispersibility of ZnO nanoparticles was observed to be significantly improved upon functionalization by PS brushes. The controlled nature of the surface initiated thiol-lactam aided polymerization of St from the ZnO nanoparticles surface was confirmed by GPC analysis.</P>
The Dominant Role of Forkhead Box Proteins in Cancer
Bach, Duc-Hiep,Long, Nguyen Phuoc,Luu, Thi-Thu-Trang,Anh, Nguyen Hoang,Kwon, Sung Won,Lee, Sang Kook MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.10
<P>Forkhead box (FOX) proteins are multifaceted transcription factors that are significantly implicated in cancer, with various critical roles in biological processes. Herein, we provide an overview of several key members of the FOXA, FOXC, FOXM1, FOXO and FOXP subfamilies. Important pathophysiological processes of FOX transcription factors at multiple levels in a context-dependent manner are discussed. We also specifically summarize some major aspects of FOX transcription factors in association with cancer research such as drug resistance, tumor growth, genomic alterations or drivers of initiation. Finally, we suggest that targeting FOX proteins may be a potential therapeutic strategy to combat cancer.</P>
Bach, Long Giang,Islam, Md. Rafiqul,Gal, Yeong Soon,Lim, Kwon Taek American Scientific Publishers 2012 Journal of Nanoscience and Nanotechnology Vol.12 No.7
<P>An approach to the surface modification of TiO2 nanoparticles was described based on the thiol functionalization of TiO2 followed by thiol-lactam initiated radical polymerization (TLIRP) of methyl methacrylate (MMA). FT-IR, XRD and XPS analyses confirmed the grafting of the polymer on the TiO2 surface. TGA analysis revealed superior thermal stability of PMMA-g-TiO2 compared with PMMA. TEM measurements and time-dependent phase monitoring suggested much higher colloidal stability of PMMA-g-TiO2 than TiO2 in toluene. The controlled nature of the TLIRP of MMA from the surface of TiO2 was determined by GPC analysis.</P>
CALIBRATION OF STELLAR PARAMETERS OF 85 PEG SYSTEM
Bach, Kiehunn,Kim, Yong-Cheol,Demarque, Pierre The Korean Space Science Society 2007 Journal of Astronomy and Space Sciences Vol.24 No.1
We have investigated the evolutionary status of 85 Peg within the framework of standard evolutionary theory. 85 Peg has been known to be a visual and spectroscopic binary system in the solar neighborhood. In spite of the accurate information of the total mass (${\sim}1.5M_{\odot}$) and the distance (${\sim}12pc$) from the HIPPARCOS parallax, it has been undetermined an individual mass, therefore the evolved status of the system. Moreover, the coupled uncertainties of chemical composition and age, make matters worse in predicting an evolutionary status of the system. Nevertheless, we computed the various possible models for 85 Peg, and then calibrated stellar parameters by adjusting to the recent observational data. Our modelling computation has included recently updated input physics and stellar theory such as opacity, equation of state, and chemical diffusion. Through a statistical assessment, we have derived a confident parameter set as the best solution which minimized $X^{2}$ within the observational error domain. Most of all, we found that 85 Peg is not a binary system but a triple system with an unseen companion 85 Peg $B_{b}\;{\sim}0.16M_{\odot}$. The aim of the present paper is (1) to provide a complete modelling of the stellar system based on the evolutionary theory, and (2) to constrain the physical dimensions such as mass, metallicity and age.