http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Phase Evolution of an Al-B-N Nanocomposite Prepared from a Preceramic Polymer Mixture
Jeon, Jong-Kyu,Gervais, Christel,Babonneau, Florence,Kim, Dong-pyo 한국공업화학회 2004 Journal of Industrial and Engineering Chemistry Vol.10 No.5
The phase evolution of an Al-B-N ternary system was studied using mixture of nanosized Al metal powder and polyborazine, as a source of boron and nitrogen, which was pyrolyzed at 1200℃ in an Ar atmosphere. The precursor system initially formed an Al/AlN mixture when annealed at 700℃, and then it converted to AlN/BN/ A1B₂ nanocomposite phase at 900℃. Interestingly, we observed that, at 1200℃, the AlB₂ formed was reduced partly to Al metal embedded in the nanocomposite phase. The systems were investigated using XRD, XPS, and both ^(27)Al and ^(11)B solid state NMR spectroscopies.
Mycobacterial Toxin Induces Analgesia in Buruli Ulcer by Targeting the Angiotensin Pathways
Marion, E.,Song, O.R.,Christophe, T.,Babonneau, J.,Fenistein, D.,Eyer, J.,Letournel, F.,Henrion, D.,Clere, N.,Paille, V.,Guerineau, Nathalie C.,Saint Andre, J.P.,Gersbach, P.,Altmann, K.H.,Stinear, T. Cell Press ; MIT Press 2014 Cell Vol.157 No.7
Mycobacterium ulcerans, the etiological agent of Buruli ulcer, causes extensive skin lesions, which despite their severity are not accompanied by pain. It was previously thought that this remarkable analgesia is ensured by direct nerve cell destruction. We demonstrate here that M. ulcerans-induced hypoesthesia is instead achieved through a specific neurological pathway triggered by the secreted mycobacterial polyketide mycolactone. We decipher this pathway at the molecular level, showing that mycolactone elicits signaling through type 2 angiotensin II receptors (AT<SUB>2</SUB>Rs), leading to potassium-dependent hyperpolarization of neurons. We further validate the physiological relevance of this mechanism with in vivo studies of pain sensitivity in mice infected with M. ulcerans, following the disruption of the identified pathway. Our findings shed new light on molecular mechanisms evolved by natural systems for the induction of very effective analgesia, opening up the prospect of new families of analgesics derived from such systems.