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RISS 인기검색어
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- 저자 : Ayşe İriz (검색결과 1 건)
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Are Systemic Voriconazole and Caspofungin Ototoxic? An Experimental Study with Rats
Emine Aydın,Filiz Aydoğan,,Eren Taştan,,Ayşe İriz,Gökhan Karaca,İlknur Haberal Can 대한이비인후과학회 2012 Clinical and Experimental Otorhinolaryngology Vol.5 No.3
Objectives. To determine whether systemic administration of voriconazole and caspofungin causes ototoxicity. Methods. This study was conducted on 32 healthy male Wistar albino rats. The baseline auditory brainstem response (ABR)thresholds of all animals were obtained under general anesthesia. Then, the rats were randomly divided into 4 groups (groups I-IV), each group consisting of 8 rats. Rats in group I were injected intraperitoneally with voriconazole 10 mg/kg/day for 7 days, and the rats in the group II were injected intraperitoneally with caspofungin 5 mg/kg/day for 7 days. Group III received 120 mg/kg/day gentamicin for 7 days. Group IV received saline for 7 days. The animals were then observed for 7 days, and on 14th day of the trial, posttreatment ABRs of both ears were recorded. Results. We did not find any significant differences between pretreatment and posttreatment median ABR thresholds in the voriconazole, caspofungin, or saline groups. In the gentamicin group, there was a statistically significant difference between pretreatment and posttreatment ABR thresholds. Conclusion. Caspofungin and voriconazole did not change ABR thresholds in speech frequencies after a 7-day-period of their administration. We believe that further animal studies must be performed after administration of these agents for a longer time period, and these findings must be consolidated with histopathological investigations. Objectives. To determine whether systemic administration of voriconazole and caspofungin causes ototoxicity. Methods. This study was conducted on 32 healthy male Wistar albino rats. The baseline auditory brainstem response (ABR)thresholds of all animals were obtained under general anesthesia. Then, the rats were randomly divided into 4 groups (groups I-IV), each group consisting of 8 rats. Rats in group I were injected intraperitoneally with voriconazole 10 mg/kg/day for 7 days, and the rats in the group II were injected intraperitoneally with caspofungin 5 mg/kg/day for 7 days. Group III received 120 mg/kg/day gentamicin for 7 days. Group IV received saline for 7 days. The animals were then observed for 7 days, and on 14th day of the trial, posttreatment ABRs of both ears were recorded. Results. We did not find any significant differences between pretreatment and posttreatment median ABR thresholds in the voriconazole, caspofungin, or saline groups. In the gentamicin group, there was a statistically significant difference between pretreatment and posttreatment ABR thresholds. Conclusion. Caspofungin and voriconazole did not change ABR thresholds in speech frequencies after a 7-day-period of their administration. We believe that further animal studies must be performed after administration of these agents for a longer time period, and these findings must be consolidated with histopathological investigations.
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