http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Aurel Ardelean (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
-
Anca Hermenean,Aurel Ardelean,Miruna Stan,Nicoleta Hadaruga,Ciprian-Valentin Mihali,Marieta Costache,Anca Dinischiotu 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.6
The present study evaluated the antioxidant and hepatoprotective effects of the flavonoid naringenin (NGN) and its b-cyclodextrin formulation at a dose of 50 mg/kg b.w. The assessment was done by the investigation of serumenzymatic and liver antioxidant activity, histopathological and ultrastructural changes in male Swiss mice, which were subjected to acute experimental intoxication with CCl4. Formulated and free flavonoid were orally given to mice for 7 days and then were intraperitoneally injected with 1.0 mL/kg CCl4 on the 8th day. After 24 h of CCl4 administration, an increase in the levels of transaminases aspartate aminotransferase and alanine aminotransferase activities and malondialdehyde concentration occurred and a significant decrease in superoxide dismutase, catalase glutathione-peroxidase activities, and glutathione levels was detected as well. These were accompanied by extended centrilobular necrosis, steatosis, fibrosis, and an altered ultrastructure of hepatocytes. Pretreatment with formulated or free flavonoid retained the biochemical markers to control values. Histopathological and electron-microscopic examination confirmed the biochemical results. In conclusion, both NGN and NGN/b-cyclodextrin complex showed antioxidant and hepatoprotective effects against injuries induced by CCl4.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
