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Experimental Study on Ultimate Strength of Concrete Filled Double Tubular Steel with Shear Connector
Masaru Shimizu,Fumihito Tatsumi,Toshiyuki Ishikawa,Atsushi Hattori,Hirotaka Kawano 한국강구조학회 2013 International Journal of Steel Structures Vol.13 No.1
Concrete Filled Tubular steel (CFT) member, which represents a superb deformability due to well-known confined effectbetween steel tube and concrete, has been used mainly as bridge pier. As a progressive composite member, Concrete FilledDouble tubular steel (CFDT), which is consist of double skin steel tubes and filled concrete between them, has been proposed. Although a lot of reports on mechanical characteristics of the CFDT member are presently published, the necessity of shearconnector for the CFDT member has not been addressed. In this research, the shear connector was installed at the interfacebetween tubes and concrete in the CFDT member. To investigate the effect of the shear connector on the bending characteristics,the four points bending test were carried out. The results show that integrating the steel tubes and concrete enhances its bearingcapacity. Furthermore, the strains of outer and inner tubes were also discussed in this paper.
Prediction of Bending Fatigue Life of Cracked Out-of-Plane Gusset Joint Repaired by CFRP Plates
Risa Matsumoto,Takafumi Komoto,Toshiyuki Ishikawa,Atsushi Hattori,Hirotaka Kawano 한국강구조학회 2018 International Journal of Steel Structures Vol.18 No.4
Carbon fi ber reinforced polymer (CFRP), plates bonding repair method is one of the simple repair methods for cracked steel structures. In this study, the infl uence of width of CFRP plates on bending fatigue life of out-of-plane gusset joint strengthened with CFRP plates was investigated from the experimental and numerical point of view. In the bending fatigue test of cracked out-of-plane gusset joint strengthened with CFRP plates, the eff ect of width of CFRP plates on crack growth life was clarifi ed experimentally. Namely, it was revealed that the crack growth life becomes larger with increasing the width of CFRP plates. In the numerical approach, the stress intensity factor ( SIF ) at the surface point of a semi-elliptical surface crack was estimated based on the linear fracture mechanics. Furthermore, the extended fatigue life of cracked out-of-plane gusset joint strengthened with CFRP plates was evaluated by using the estimated SIF at the surface point and the empirical formula of the aspect ratio of semi-elliptical crack. As the results of numerical analysis, the estimated fatigue life of the specimen strengthened with CFRP plates showed the good agreement with the test results.
STANDARD SPECIFICATION FOR CONCRETE STRUCTURES, -2001 “MAINTENANCE”
Toyoaki Miyagawa,Hidenori Morikawa,Nobuaki Otsuki,Ayaho Miyamoto,Kazuo Eguchi,Hidenori Hamada,Atsushi Hattori,Tetsuo Harada,Susumu Inoue,Yuichi Kaneko,Yasushi Kamihigashi,Kenji Kawai,Masaru Kawamura,Y 대한토목학회 2003 대한토목학회 학술대회 Vol.2003 No.10
Rescue levodopa/carbidopa intestinal gel for secondary deep brain stimulation failure
Juan Miguel Pilar Bautista,Genko Oyama,Maierdanjiang Nuermaimaiti,Satoko Sekimoto,Fuyuko Sasaki,Taku Hatano,Kenya Nishioka,Masanobu Ito,Atsushi Umemura,Yuji Ishibashi,Yasushi Shimo,Nobutaka Hattori 대한파킨슨병및이상운동질환학회 2020 Journal Of Movement Disorders Vol.13 No.1
The long-term efficacy of deep brain stimulation (DBS) for motor fluctuations in advanced Parkinson’s disease (PD) has been well established; however, motor fluctuations may recur over time despite multiple adjustments of DBS settings and medications.
RUNX1–Survivin Axis Is a Novel Therapeutic Target for Malignant Rhabdoid Tumors
Masamitsu Mikami,Tatsuya Masuda,Takuya Kanatani,Katsutsugu Umeda,Hidefumi Hiramatsu,Hirohito Kubota,Tomoo Daifu,Atsushi Iwai,Etsuko Yamamoto Hattori,Kana Furuichi,Saho Takasaki,Sunao Tanaka,Yasuzumi M 한국분자세포생물학회 2022 Molecules and cells Vol.45 No.12
Malignant rhabdoid tumor (MRT) is a highly aggressive pediatric malignancy with no effective therapy. Therefore, it is necessary to identify a target for the development ofnovel molecule-targeting therapeutic agents. In this study, we report the importance of the runt-related transcription factor 1 (RUNX1) and RUNX1–Baculoviral IAP (inhibitor of apoptosis) Repeat-Containing 5 (BIRC5/survivin) axis in the proliferation of MRT cells, as it can be used as an ideal target for anti-tumor strategies. The mechanism of this reaction can be explained by the interaction of RUNX1 with the RUNX1-binding DNA sequence located in the survivin promoter and its positive regulation. Specific knockdown of RUNX1 led to decreased expression of survivin, which subsequently suppressed the proliferation of MRT cells in vitro and in vivo. We also found that our novel RUNX inhibitor, Chb-M, which switches off RUNX1 using alkylating agent-conjugated pyrrole-imidazole polyamides designed to specifically bind to consensus RUNX-binding sequences (5′-TGTGGT-3′), inhibited survivin expression in vivo. Taken together, we identified a novel interaction between RUNX1 and survivin in MRT. Therefore the negative regulation of RUNX1 activity may be a novel strategy for MRT treatment