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RISS 인기검색어
- 검색키워드
- 저자 : Asmaa Al-Rashed (검색결과 3 건)
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Ibrahim, Mona H,Rashed, Reham A,Hassan, Naglaa M,Al-azhary, Nevin M,Salama, Asmaa I,Mostafa, Marwa N Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.6
It is thought that population characteristics of breast cancer may be due to a variation in the frequency of different alleles of genes such as CYP1B1. We aimed to determine the association of CYP1B1 polymorphisms in 200 breast cancer cases and 40 controls by PCR-RFLP. Frequencies were assessed with clinical and risk factors in Egyptian patients. The genotype LV and the Leu allele frequencies for patients and controls were 42.9% and 50%, and 52.9% and 53.3%, respectively), with no significant differences observed (P values = 0.8 and 0.6, respectively). There was also no significant association between genotypes and any risk factors for cases (P>0.05) except laterality and metastasis of the tumor (P values=0.006 and 0.06, respectively). The CYP1B1 polymorphism Val432Leu was not associated with breast cancer in Egypt, but may provide clues for future studies into early detection of the disease.
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Wadha Alfouzan,Zainab Al-Balushi,Muna Al-Maslamani,Asmaa Al-Rashed,Salman Al-Sabah,Jameela Al-Salman,Mohamed Baguneid,Faryal Khamis,Nervana Habashy,Ayman Kurdi,Christian Eckmann 대한외상중환자외과학회 2021 Journal of Acute Care Surgery Vol.11 No.3
The number of complicated skin and soft tissue infections (cSSTIs) in the Arabian Gulf region has risen in recent years, particularly those caused by multi-drug resistant (MDR) pathogens. The high prevalence of diabetes, obesity, and associated cardio-metabolic comorbidities in the region renders medical and surgical management of cSSTI patients with MDR infections challenging. An experienced panel of international and regional cSSTI experts (consensus group on cSSTIs) was convened to discuss clinical considerations for MDR infections from societal, antimicrobial stewardship, and cost perspectives, to develop best practice recommendations. This article discusses antibiotic therapies suitable for treating MDR cSSTIs in patients from the Gulf region and recommends that these should be tailored according to the local bacterial ecology by country and region. The article highlights the need for a comprehensive patient treatment pathway and defined roles of each of the multidisciplinary teams involved with managing patients with MDR cSSTIs. Aligned and inclusive definitions of cSSTIs for clinical and research purposes, thorough and updated epidemiological data on cSSTIs and methicillin-resistant Staphylococcus aureus in the region, clearcut indications of novel agents and comprehensive assessment of comparative data should be factored into decision-making are necessary. The number of complicated skin and soft tissue infections (cSSTIs) in the Arabian Gulf region has risen in recent years, particularly those caused by multi-drug resistant (MDR) pathogens. The high prevalence of diabetes, obesity, and associated cardio-metabolic comorbidities in the region renders medical and surgical management of cSSTI patients with MDR infections challenging. An experienced panel of international and regional cSSTI experts (consensus group on cSSTIs) was convened to discuss clinical considerations for MDR infections from societal, antimicrobial stewardship, and cost perspectives, to develop best practice recommendations. This article discusses antibiotic therapies suitable for treating MDR cSSTIs in patients from the Gulf region and recommends that these should be tailored according to the local bacterial ecology by country and region. The article highlights the need for a comprehensive patient treatment pathway and defined roles of each of the multidisciplinary teams involved with managing patients with MDR cSSTIs. Aligned and inclusive definitions of cSSTIs for clinical and research purposes, thorough and updated epidemiological data on cSSTIs and methicillin-resistant Staphylococcus aureus in the region, clear-cut indications of novel agents and comprehensive assessment of comparative data should be factored into decision-making are necessary.
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Eman Mumtaz El Mahdy,Maha Gamal,Basma Emad Aboulhoda,Basent Adel Al Dreny,Ashraf Shamaa,Laila Rashed,Ahmed Nour Eldine Abdallah,Asmaa M. Shamseldeen 한국통합생물학회 2023 Animal cells and systems Vol.27 No.1
Parkinson’s disease (PD), the second common neurodegenerative disease, is characterized by theloss of the dopaminergic neurons in the substantia nigra (SN). Because of L-dopa’s side effects, newtherapeutic methods were considered such as stem cells for PD treatment. The major challengefacing stem cell therapy following transplantations is their peripheral sequestration anddecreased survival. Thus, the ability of erythropoietin (EPO) and low-level laser therapy (LLLT) toenhance mesenchymal stem cell (MSC) proliferation and therapeutic efficiency for alleviatingrotenone-induced PD was investigated. Therefore, we compared the influence of stem cellpreconditioning with erythropoietin versus LLLT on MSCs’ homing ability and the chances ofsurvival. Forty-eight male Swiss mice were included in the in vivo protocol and ten in the invitro work. The mice in the in vivo study were divided randomly into six groups (8 in each);group I; control group and group II; induced PD (untreated) group, group III; L-dopa, group IV;MSCs, group V; EPO-activated MSCs and group VI; laser-activated MSCs. Treatment with MSCs(either preconditioned or not) improved these neurological features by restoring the normalbalance between glutamate and GABA neurotransmitters, and dopamine as well as increasedtyrosine hydroxylase levels. Stem cell therapy decreased oxidative stress, miRNA-155 levels,enhanced neuronal architecture in SN, and decreased the number of apoptotic cells. LLLTenhanced MSC expression of integrin β1 which was reflected in the homing of PKH26-labelledMSCs into corpus striatum and SN. Thus, the optimum results were achieved with laseractivatedMSCs.
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