Aerobic exercise training in Kartagener’s syndrome : case report

Aslihan Cakmak,Deniz Inal-Ince,Hazal Sonbahar-Ulu,Cemile Bozdemir-Ozel,Haluk Tekerlek,Melda Saglam,Ebru Calik-Kutukcu,Naciye Vardar-Yagli,Elmas Ebru Yalcin,Ugur Ozcelik,Hulya Arikan 한국운동재활학회 2019 JER Vol.15 No.3

Dental Findings in Cornelia De Lange Syndrome

Aslihan Soyal Toker,Sinan Ay,Hasan Yeler,Ilhan Sezgin 연세대학교의과대학 2009 Yonsei medical journal Vol.50 No.2

Cornelia de Lange syndrome is a congenital disease, basically characterized by psychomotor retardation associated with a series of malformations, including mainly skeletal, craniofacial deformities together with gastrointestinal and cardiac malformations. There is no definitive biochemical or chromosomal marker for the prenatal diagnosis of this syndrome. We actually want to present the case of a 10-year-old patient, who was admitted to our clinic for dental pain. The patient had the symptoms of Cornelia de Lange syndrome. During the oral examination of this patient, the patient was found to have the typical symptoms of Cornelia de Lange syndrome, such as micrognathia and delayed eruption in conjunction with the symptoms of the Hutchinson’s syndrome, which had never been reported before. Cornelia de Lange syndrome is a congenital disease, basically characterized by psychomotor retardation associated with a series of malformations, including mainly skeletal, craniofacial deformities together with gastrointestinal and cardiac malformations. There is no definitive biochemical or chromosomal marker for the prenatal diagnosis of this syndrome. We actually want to present the case of a 10-year-old patient, who was admitted to our clinic for dental pain. The patient had the symptoms of Cornelia de Lange syndrome. During the oral examination of this patient, the patient was found to have the typical symptoms of Cornelia de Lange syndrome, such as micrognathia and delayed eruption in conjunction with the symptoms of the Hutchinson’s syndrome, which had never been reported before.

Effects of grape seed proanthocyanidin extract on side effects of high-dose methylprednisolone administration in male rats

Sur Aslihan,Iflazoglu Mutlu Seda,Tatli Seven Pinar,Seven Ismail,Aslan Abdullah,Kizil Meltem,Kulaksiz Recai,Yaranoglu Mustafa Hilmi,Esen Selim 한국독성학회 2023 Toxicological Research Vol.39 No.4

In this study, we investigated the effects of grape seed proanthocyanidin extract (GSPE) against the side effects of highdose administration of methylprednisolone (MP) in male rats. A total of 32 adult Wistar male albino rats were divided into four groups: (1) control (CON), received standard food only; (2) MP, received standard food + intraperitoneal injection of 60 mg/kg MP on day 7; (3) GSPE, received standard food + 200 mg/kg/day GSPE; and (4) MP + GSPE, received standard food + 200 mg/kg/day of GSPE + intraperitoneal injection of 60 mg/kg MP on day 7. All animals in the GSPE and GSPE + MP groups were treated once a day by oral gavage for 14 consecutive days. The feed intake of rats in the MP and MP + GSPE groups decreased significantly by 24.14% and 13.52%, respectively (p < 0.05). Administration of MP resulted in significant increases in serum concentrations of blood urea nitrogen (p < 0.001), glucose (p < 0.01), alkaline phosphatase, and adrenocorticotropic hormone (p < 0.05). High-dose MP administration significantly reduced catalase (p < 0.001) and glutathione peroxidase (p < 0.05) concentrations in the liver and kidney tissues of rats, while glutathione concentrations were only reduced in liver tissue (p < 0.05). The expression levels of Bcl-2 and TNF-α in liver, kidney, and testicular tissue were significantly increased, while the expression levels of caspase-3 were reduced (p < 0.001). Furthermore, sperm concentration was significantly affected by GSPE in rats induced by high-dose MP, and sperm loss was significantly reduced in MP + GSPE (p < 0.05). These findings suggest that GSPE could be useful as a supplement to alleviate MP-induced toxicity in rats.

Coexistence of Darier's Disease and Acrokeratosis Verruciformis of Hopf

Suleyman Piskin,Aslihan Saygin,Latife Doganay,Deniz Kircuval,Eylem Gurkan 연세대학교의과대학 2004 Yonsei medical journal Vol.45 No.5

Darier's disease and acrokeratosis verruciformis are inherited with the same pattern and they share similar clinical properties. We present a patient with both Darier's disease and acrokeratosis verruciformis. The patient had had brownish and skin-colored papules, initially on her face and neck, since the age of 25. Similar lesions had gradually spread to various parts of her body and lastly the dorsal aspect of her feet. On dermatological examination, brownish and skin-colored, 2 to 5mm, keratotic papules were observed on her face, neck, both axillae, inframammary regions, and dorsa of the hands and feet. The nail examination revealed “V” shaped notches and longitudinal ridges on the fingers of both hands. The biopsy taken from the neck showed typical findings for Darier's disease. The biopsy from the dorsa of the left foot revealed the distinctive structures of acrokeratosis verruciformis. In this article the clinical and histopathological findings of these diseases are reviewed based on our patient.

Resistance to Macrolide, Lincosamide and Streptogramin Antibiotics in Staphylococci Isolated in Istanbul, Turkey

Zerrin Aktas,Aslihan Aridogan,Cigdem Bal Kayacan,Derya Aydin 한국미생물학회 2007 The journal of microbiology Vol.45 No.4

The purpose of this study was to investigate the prevalence and genetic mechanisms of erythromycin resistance in staphylococci. A total of 102 erythromycin resistant non-duplicate clinical isolates of staphylococci [78 coagulase negative stapylococci (CNS), 24 Staphylococcus aureus] were collected between October 2003 and August 2004 in Istanbul Faculty of Medicine in Turkey. The majority of the isolates were from blood and urine specimens. Antimicrobial susceptibilities were determined by the agar dilution procedure and the resistance phenotypes by the double disk induction test. A multiplex PCR was performed, using primers specific for erm(A), erm(B), erm(C), and msrA genes. Among the 78 CNS isolates, 57.8% expressed the MLSB-constitutive, 20.6% the MLSB-inducible, and 21.6% the MSB phenotypes. By PCR, 78.2% of these isolates harbored the erm(C) gene, 8.9% erm(A), 6.4% erm(B), and 11.5% msrA genes. In S. aureus, the constitutive MLSB (58.3%) was more common than the inducible phenotype (20.8%). erm(A) was detected in 50% and erm(C) in 62.5% of the isolates, while 37.5% contained both erm(A) and erm(C). erm(C)-associated macrolide resistance was the most prevalent in CNS, while erm(C) and erm(A, C) was the most prevalent in S. aureus.

Experimental study on the rheology of anisotropic, flocculated and low volume fraction colloids

Ozel, Burcu Genc,Orum, Aslihan,Yildiz, Mehmet,Menceloglu, Yusuf Z. 한국유변학회 2014 Korea-Australia rheology journal Vol.26 No.1

In this work, we have investigated rheological behavior of colloids with a low particle volume fraction, and anisotropic and flocculated microstructures through measuring their viscosity and electrical resistance under varying shear rates together with utilizing several relevant characterization methods (i.e., Dynamic Light Scattering, Transmission Electron Microscopy, Atomic Force Microscopy, and Capacitance and Electrical resistance measurements). The colloids are formed through the suspension of hydrophilic/phobic fumed silica particle with attractive/repulsive interaction in polyethylene glycol and/or ethylene oxide-propylene oxide copolymer. It is observed that studied suspensions display shear thickening/thinning flow behavior depending on their microstructure (the spatial distribution and arrangements of particles in continuous media) and associated changes in cluster sizes, which are controlled by the break down of densified clusters (due to the shear induced mechanical and hydrodynamical forces) and the interaction forces among particle-particle and particles-polymers (owing to physicochemical effects). The detailed evaluation of the experimental results indicates that the shear thickening phenomena in low volume fraction, anisotropic and flocculated systems can be mainly attributed to the increase in the effective volume fraction of particles due to both hydrodynamic and physicochemical forces.

A novel sulfonated aromatic polyimide synthesis and characterization: Energy calculations, QTAIM simulation study of the hydrated structure of one unit

Yildiko Umit,Tanriverdi Aslihan Aycan 대한화학회 2022 Bulletin of the Korean Chemical Society Vol.43 No.6

A new type of sulfonated polyimide was synthesized from a one-step polycondensation reaction with perylene-3,4,9,10-tetracarboxylic dianhydride and 4,40- diamino-2,20-stilbenedisulfonic. Pure characterization of sulfonated polyimide (SPI) was performed by Fourier transform infrared spectroscopy, proton nuclear magnetic resonance, thermogravimetric analysis, differential thermal gravimetric analysis, ultraviolet–visible spectroscopy, and solubility tests. Moreover, the SPI film was prepared by a thermal imidization step heating procedure. Furthermore, quantum chemical calculations of the synthesized SPI were investigated with density functional theory (DFT) and time-dependent density functional theory. By calculating the frontiers molecular orbital energies of the obtained polyimide, the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO), and the energy gap (Δ) values were found for the one structural unit and three structural units of SPI, respectively. Also, QTAIM was carried out based on the AIMAll program. With the increase in water molecules, the average electronic energy density (HBCP) value decreased according to the results of QTAIM. The SPI can be used as a potential membrane in fuel cells.

Resistance to Macrolide, Lincosamide and Streptogramin Antibiotics in Staphylococci Isolated in Istanbul, Turkey

Aktas, Zerrin,Aridogan, Aslihan,Kayacan, Cigdem Bal,Aydin, Derya The Microbiological Society of Korea 2007 The journal of microbiology Vol.45 No.4

The purpose of this study was to investigate the prevalence and genetic mechanisms of erythromycin resistance in staphylococci. A total of 102 erythromycin resistant non-duplicate clinical isolates of staphylococci [78. coagulase negative stapylococci (CNS), 24 Staphylococcus aureus] were collected between October 2003 and August 2004 in Istanbul Faculty of Medicine in Turkey. The majority of the isolates were from blood and urine specimens. Antimicrobial susceptibilities were determined by the agar dilution procedure and the resistance phenotypes by the double disk induction test. A multiplex PCR was performed, using primers specific for erm(A), erm(B), erm(C), and msrA genes.. Among the 78 CNS isolates, 57.8% expressed the $MLS_{B}-constitutive$, 20.6% the $MLS_{B}-inducible$, and 21.6% the $MS_B$ phenotypes. By PCR, 78.2% of these isolates harbored the erm(C) gene, 8.9% erm(A), 6.4% erm(B), and 11.5% msrA genes. In S. aureus, the constitutive $MLS_B$ (58.3 %) was more common than the inducible phenotype (20.8%). erm(A) was detected in 50% and erm(C) in 62.5% of the isolates, while 37.5% contained both erm(A) and erm(C). erm(C)-associated macrolide resistance was the most prevalent in CNS, while ermC) and erm(A, C) was the most prevalent in S. aureus.

The effect of coloring liquids on the translucency of zirconia framework

Tugrul Sari,Erdal Eroglu,Aslihan Usumez,Ilkin Tuncel 대한치과보철학회 2013 The Journal of Advanced Prosthodontics Vol.5 No.4

PURPOSE Translucency of all-ceramic restorations is an important factor which affects the final appearance and esthetic outcome of the restoration. The aim of this study was to evaluate the effect of the shade of coloring liquid on the translucency of zirconia framework. MATERIALS AND METHODS Thirty zirconium oxide core plate (15 × 12 × 0.5 mm) were divided into 6 groups of 5 plates each. Each group was classified according to the shade of coloring liquid based on Vita Classic Scale (A2, A3, B1, C2, and D2), and each sample was immersed in coloring liquid for 3 seconds as recommended by the manufacturer, except for the control group. Contrast ratio, as a translucency parameter, was calculated using a spectrophotometer and the data were analyzed with oneway analysis of variance (ANOVA) and Tukey's honestly significant differences (HSD) tests (α=.05). RESULTS Significant differences in translucency among the control and test groups, and the B1 shaded group and other shades was observed. There were no significant differences among A2, A3, C2, and D2 shaded groups. CONCLUSION The translucency of the zirconium oxide cores was affected by the coloring procedure and significant differences in the translucency measurements were identified between specific shades.

Antioxidant and anticancer activities of gallic acid loaded sodium alginate microspheres on colon cancer

Sagdicoglu Celep A. Gulcin,Demirkaya Aslihan,Solak Ebru Kondolot 한국물리학회 2022 Current Applied Physics Vol.40 No.-

Polyphenols found in fruits and vegetables are of great interest due to their health benefits. Gallic acid (GA) is an antioxidant with cytotoxic effects. Microspheres are drug carrier systems, where the active substance is trapped in matrix. A controlled release profile is aimed at the target region by preserving the loss of substance and activity. In this study, GA containing microspheres were formed with sodium alginate (NaAlg) in formulations with different ratios. The arrest efficiencies ranged between 11.26 and 72.64%. Release studies were performed at pH 7.4. Optimum conditions were determined as GA/NaAlg ratio 1/8. The microspheres were found to arrest GA and exhibit a controlled release profile. Microspheres were characterized by scanning electron microscope (SEM), differential scanning calorimetry (DSC), X-Ray diffraction (XRD), Fourier transform infrared spectrometer (FTIR) analysis. GA retained its antioxidant activity determined by DPPH (2,2-diphenyl-1-picrylhydrazyl) method and anticancer activity on Caco-2 cells. Further studies are necessary on GA-loaded NaAlg microspheres which have high potential to be used in adjunct and complementary therapies.