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Evaluation and Characterization of Fluroquinone Antibiotic loaded in to Polymeric Nanofibers.
Arthanari Saravanakumar(아따나리 사라바나 쿠멀),Mani Ganesh(마니가니쉬),Jun Ho Jang(장준호),Je O Choi(최제오),Yun Ho Cho(조윤호),Jung Ho Lee(이정호),Seung Eun Cha(차성은),Han Seok Oh(오한석),Deok Han Kwon(권덕한),장현태 한국산학기술학회 2014 한국산학기술학회 학술대회 Vol.2014 No.2
The aim of this study was to develop novel biomedicated electrospun nanofiber for controlled release. Pre-formulation studies were carried out for nanofibers of sodium alginate(2 wt.%) (SA)/polyvinyl alcohol(10 wt.%) (PVA) (2:8, 3:7 and 1:9) composites by an electrospinning technique. The morphology and average diameter of the nanofibers were investigated by scanning electron microscopy. The optimum ratio(3:7) was used for loading of gatifloxacin hydrochloride (GH) (1wt.%), found to form smooth fibers with uniform structures. The drug entrapment, in the composite nanofibers was confirmed by scanning electron microscopy, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), thermo gravimetric analysis (TGA),differential scanning calorimetry (DSC) and swelling behavior. The drug release behavior was investigated by using phosphate buffered saline (PBS) (pH 7.4) at 37°C for 24hrs. XRD and FT-IR data demonstrates that there are good interactions between PVA and SA caused by possibly hydrogen bonds. As much as 90 % of the GH was released from the electrospun fibers within 6hrs of incubation, beyond this the release was sustained for 24hrs. The thickness of nanofibers greatly influenced the initial release and rate of drug release. Moreover, GH loaded sodium alginate / PVA composite nanofibers exhibited a useful and convenient method for electrospinning in order to control the rate and period of drug release in wound healing applications.
Arthanari Saravanakumar(아따나리 사라바나 쿠멀),Mani Ganesh(마니 가니쉬),Mei Mei Peng(펭메이메이),Abidov Sh Aziz(아비도프아지즈),Hyun Tae Jang(장현태) 한국산학기술학회 2014 한국산학기술학회 학술대회 Vol.2014 No.2
Antioxidant, antimycobacterial activity of opuntia ficus-indica fruit (OFI) extracts were evaluated according to seasonable cultivation. The antioxidant activities of OFI extracts were assessed by different in vitro methods and the total phenolic and flavonoid contents were also examined. The antimycobacterial activity was measured against Mycobacterium tuberculosis strains H37Rv (ATCC 27294) by microplate alamar blue assay (MABA) method. In antioxidant assay, methanol extracts of OFI in summer season showed the highest antioxidant activity in all tested methods and the lowest IC50wasobservedin2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. Pearson correlation coefficient was evaluated and the results from the extracts of summer and rainy season OFI were significantly correlated with the total phenolic and flavonoid contents. However, the methanol extracts of OFI in summer showed high level of antimycobacterial activity against the strain of M. tuberculosis H37Rv, with minimum inhibitory concentration (MIC) of 50 µg/ml. The results from this study suggest that OFI could probably be an important source of antioxidant as well as antimycobacterial against M. tuberculosis.