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        Ultralow fouling of fibrinogen and human platelets on ulvan multilayer-coated solid surfaces

        Arisu Lee,Sung Min Kang 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.82 No.-

        Enhancement of blood compatibility with the implant surface is critical for biomedical devices. Coatingsolid surfaces with an anticoagulant is a potentially promising strategy to improve blood compatibilitywith the implant surface. This study aimed to develop an approach to enhance blood compatibility withtitanium/titanium dioxide (Ti/TiO2) surfaces using a green seaweed-derived polysaccharide ulvan. Theapproach comprises surface coating with tannic acid (TA) and grafting of ulvan onto the surface. Zirconium(IV)-based coordination linkage between ulvan and TA facilitated robust deposition of ulvanmultilayers onto Ti/TiO2 surfaces. Adhesion assays revealed that more than 95% offibrinogen adsorptionand platelet adhesion was suppressed through an ulvan multilayer coating. The present results show thatulvan multilayers are robust against chemical and physical treatments and resistant to the adsorption ofadherent proteins and human platelets.

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