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Burkholderia cepacia Complex Infection in a Cohort of Italian Patients with Cystic Fibrosis
Lambiase, Antonietta,Raia, Valeria,Stefani, Stefania,Sepe, Angela,Ferri, Pasqualina,Buonpensiero, Paolo,Rossano, Fabio,Pezzo, Mariassunta Del The Microbiological Society of Korea 2007 The journal of microbiology Vol.45 No.3
The aims of this study were to detect Burkholderia cepacia complex (Bcc) strains in a cohort of Cystic Fibrosis patients (n=276) and to characterize Bcc isolates by molecular techniques. The results showed that 11.23% of patients were infected by Bcc. Burkholderia cenocepacia lineage III-A was the most prevalent species (64.3%) and, of these, 10% was cblA positive and 50% esmR positive. Less than half of the strains were sensitive to ceftazidime, meropenem, piperacillin-tazobactam, and trimethoprim-sulfamethoxazole. About half of the strains (41%) had homogeneous profiles, suggesting cross-transmission. The infection by B. cenocepacia was associated to a high rate of mortality (p=0.01).
Burkholderia cepacia Complex Infection in a Cohort of Italian Patients with Cystic Fibrosis
Antonietta Lambiase,Valeria Raia,Stefania Stefani,Angela Sepe,Pasqualina Ferri,Paolo Buonpensiero,Fabio Rossano,Mariassunta Del Pezzo 한국미생물학회 2007 The journal of microbiology Vol.45 No.3
The aims of this study were to detect Burkholderia cepacia complex (Bcc) strains in a cohort of Cystic Fibrosis patients (n=276) and to characterize Bcc isolates by molecular techniques. The results showed that 11.23% of patients were infected by Bcc. Burkholderia cenocepacia lineage III-A was the most prevalent species (64.3%) and, of these, 10% was cblA positive and 50% esmR positive. Less than half of the strains were sensitive to ceftazidime, meropenem, piperacillin-tazobactam, and trimethoprim-sulfamethoxazole. About half of the strains (41%) had homogeneous profiles, suggesting cross-transmission. The infection by B. cenocepacia was associated to a high rate of mortality (p=0.01).