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Glucan and Humic Acid: Synergistic Effects on the Immune System
Vaclav Vetvicka,Roberto Baigorri,Angel M. Zamarreno,Jose M. Garcia-Mina,Jean-Claude Yvin 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.4
Humic acids are compounds resulting from decomposition of organic matter. Despite their common presence, our knowledge of their biological effects is limited, and current findings are controversial. We decided to evaluate the immunological effects of two different types of humic acids, differing in source and biochemical characteristics. Using both components either alone or in combination with the well-established yeast-derived immunomodulator glucan, we measured their effects on both the cellular (phagocytosis and tumor suppression) and humoral (antibody production and cytokine secretion) branches of immune reactions. In summary, our results suggest that humic acids are biologically active immunodulators affecting both the humoral and cellular branches of immune reactions. In addition, the two humic acids studied here are working in synergy in stimulation of the immune reaction, supporting further studies of these natural immunomodulators.