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- 검색키워드
- 저자 : Andrew Padalhin (검색결과 18 건)
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Padalhin, Andrew R.,Kim, Boram,Ventura, Reiza D.,Lee, Hyun Jung,Lee, Seung Jin,Lee, Byong-Taek Elsevier 2018 Materials & Design Vol.158 No.-
<P><B>Abstract</B></P> <P>Bone loss and fractures are becoming a common problem due to the aging of the global population. To aid such cases, less invasive procedures for bone regeneration have been developed using injectable bone substitutes. However, injectable materials for bone are commonly composed of inert materials that only provide structural support and still pose a risk of leakage, which contributes to morbidity. This study attempts to address this problem through evaluation of different types of electrospun fibers and their potential for facilitating the use of calcium phosphate-based cement in vertebral augmentation procedure. Thin (0.83 ± 0.31 μm fiber diameter) and thick (5.25 ± 1.22 μm fiber diameter) electrospun polycaprolactone (PCL) membranes were fabricated and surface modified through hydrolysis and simulated body fluid (SBF) apatite deposition. Samples composed of thin fibers generally retain most of their relevant properties following surface modification, while a significant change was observed in samples composed of thick fibers. The results show that thin electrospun fibers possess desirable mechanical properties for injectable cement encapsulation, while thick electrospun fibers provide a better substrate for pre-osteoblast cells. Balloon samples fabricated from both fiber types were used to test inflation capacity, encapsulation of injectable cement, and bone tissue development in an animal model.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Electrospun fibers can be used for encapsulating calcium-phosphate based injectable cement. </LI> <LI> Fiber diameter, porosity and shape design influences biocompatibility and encapsulation capacity of the fibrous balloon. </LI> <LI> Thin and thick electrospun fibers can be combined to create an effective encapsulation balloon for injectable CPC cement. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Lasers and Robots: Recent Developments in Transoral Laser and Transoral Robotic Surgery
Andrew Reyes Padalhin 대한의학레이저학회 2020 MEDICAL LASERS Vol.9 No.2
Transoral microsurgery has come a long way as a go-to surgical intervention technique for head and neck cancers. This minimally invasive procedure had gained acceptance through comparative clinical studies against radical neck surgical procedures, radiotherapy, and chemotherapy. Laser technology has vastly improved the oncological outcomes of this procedure and brought about an appreciation of transoral laser surgery (TLM) as a mainstay for re-sectioning malignant tumors along the throat. As an established procedure, TLM has undergone several upgrades regarding the different energy devices used for cutting, ablation, and hemostasis. Continued advances in automation have eventually led to surgical robotics, resulting in the emergence of transoral robotic surgery (TORS) as a viable advanced alternative for TLM. Similarly, expansions and enhancements (image-based guidance, fluorescence spectroscopy, and advanced robotic system) have also been investigated as potential upgrades for TORS. This paper reviews a selection of publications on the significant technological advancements to TLM and TORS over the past five years.
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Andrew Padalhin 대한의학레이저학회 2022 MEDICAL LASERS Vol.11 No.1
Phototherapy has come a long way from simply relying on sunlight as a light source for the treatment of various dermatological conditions. Several new developments have already found application in clinical settings, and further investigations are currently advancing its utility in combination with other therapeutic approaches. This review presents data from select publications with novel (stand-alone or combined) photodynamic therapy (PDT) and photobiomodulation (PBM) for dermal wound management and skin tissue regeneration. This article specifically includes several therapeutic approaches combined with either photodynamic therapy or photobiomodulation which uses red to near-infrared wavelengths. The noteworthy approaches detailed in the article include the use of PDT for anti-microbial applications; PBM for the management of adverse effects of toxins; dual-wavelength light therapy; the use of PBM with hydrogels; and the combined application of either drug or naturally derived therapeutic agents with PBM.
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Quantum technology: a beacon of light for next-generation healthcare
Padalhin Andrew,Chung Phil-Sang,Woo Seung Hoon 대한의학레이저학회 2023 MEDICAL LASERS Vol.12 No.4
Quantum theory diverges from classical physics by identifying discrete states instead of a continuous spectrum. While quantum phenomena have evolved independently from biology, the fields are converging, particularly in medical science. Understanding quantum principles is crucial for advancing medical technologies, as evidenced by the current developments outlined in selected articles from the past decade. Despite decades of existence, the full realization of the benefits of quantum physics has yet to be achieved. Recent technological advances, rooted in quantum principles, include quantum computers, artificial intelligence (AI) quantum algorithms, quantum-based lasers, and nanoparticles. Quantum computing, a potential foundation for robust infrastructures, faces challenges, such as the need for highly controlled conditions and specialized algorithms, prompting researchers to explore possibilities and pitfalls. Hence, optimizing existing AI tools and exploring quantum computing possibilities are priorities. Advances in quantum cascade lasers (QCLs) operating at ambient temperatures and producing hyperspectral images are sought for biomedical applications. Potential breakthroughs in infrared microscopy based on QCL technology could enable the submicron resolutions of molecules. The convergence of quantum physics and biology in medical science is in its early stages. Resolving the challenges in practical quantum technology within its fundamental principles is crucial for future progress.
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Andrew Reyes Padalhin 대한의학레이저학회 2021 MEDICAL LASERS Vol.10 No.1
As technology advances at a rapid rate, innovations in regenerative medicine will eventually include the use of energy-based therapeutics, such as low intensity-pulsed ultrasound stimulation (LIPUs), pulsed electromagnetic field stimulation (PMFs), and low-level laser/light therapy (LLLt) or photobiomodulation therapy (PBMt). Among these treatments, LLLt/PBMt attracted significant attention by the turn of the century, as evidenced by the numerous publications compared to LIPUs and PMFs, particularly for augmented bone regeneration (ABR). This is a testament of how the maturation of technology and scientific knowledge leads to latent compounded applications, even when the value of a technique is reliant on empirical data. This article reviews some of the notable investigations using LLLt/PBMt for bone regeneration published in the past decade, focusing on how this type of therapy has been utilized together with the existing regenerative medicine landscape.
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Ken Woo,Andrew Padalhin 대한의학레이저학회 2023 MEDICAL LASERS Vol.12 No.1
Cancers of major organs and their treatment with chemotherapeutic agents can be difficult and challenging, both because of the disease itself, and also because of the accompanying side effects of the treatment. Recent studies in cancer biology have revealed that cancer cells have higher levels of reactive oxygen species (ROS). ROS play a dual role in physiological and pathological conditions of the human body. It is well known that ROS are engaged in many cellular activities for the preservation of cellular homeostasis. While both normal and cancer cells maintain specific levels of ROS, excess ROS leads to increased oxidative stress linked to cellular damage and potentially cell death. Emergent technologies like plasma therapy and photobiomodulation (PBM), have demonstrated their capabilities of increasing intracellular ROS levels, thus, gaining recognition as prospective cancer treatments. This review aims to summarize the effects of plasma and PBM on the ROS levels of cells as observed in previous studies and evaluate their potential to be developed as treatments for cancer.
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Kyung Wook Kim,Andrew Padalhin 대한의학레이저학회 2022 MEDICAL LASERS Vol.11 No.4
The bone is a dynamic biological tissue composed of metabolically active cells which are integrated into a hard framework. However, it can be injured due to trauma or infections and this can result in bone defects. Hence, bone generation or bone healing has been an interesting field of orthopedics and has been the subject of multiple studies. As a result, various substances which promote osteogenesis and angiogenesis have been identified, but their mechanism of action has not yet been completely elucidated. Owing to its anti-inflammatory and wound-healing effects, photobiomodulation (PBM) has been proposed in the treatment of various disease conditions. Specifically, in orthopedics, multiple studies have been conducted to treat bone generation or bone union using PBM. The clinical improvement of bone healing as well as various substances and mechanisms of osteogenesis and angiogenesis by PBM have been identified although the mechanism of action is not fully understood. This review summarizes the published reports on the bone healing effects of PBM treatment in fracture sites.
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