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Ananya Bagchi,Dillip Kumar Swain,Analava Mitra 경희대학교 융합한의과학연구소 2020 Oriental Pharmacy and Experimental Medicine Vol.20 No.3
Production of improved valued tea is in high demand due to its pharmacological properties against various neurodegenerative diseases like Alzheimer’s disease. In this study, an attempt was made to compare the protective effect of the tea grown under organic and inorganic nutrient management practices against intra-cerebroventricular (i.c.v) colchicine induced memory impairment and oxidative damage in rat model of Alzheimer’s disease (AD). Results showed that chronic intraperitoneal (i.p) administration of tea extract (20 mg/kg i.p) significantly improved the cognitive dysfunction and memory impairment in colchicine treated AD rat model. This beneficial effect occurred with an increase in α-secretase activity, Superoxide dismutase, Catalase activities, and a decrease in Acetylcholinesterase level, Aβ -42 level, Cox-2-linked neuro-inflammation by intraperitoneal injection of tea extract grown organically and inorganically. The amyloid Aβ concentration in the rat model of AD was 84 ± 1.7 pg/mg protein. With administration of tea extract, the amyloid Aβ concentration decreased significantly to 55 ± 1.5, 52 ± 1.3 and 49 ± 1.5 pg/mg protein with the field level management of inorganic, integrated and organic nutrients, respectively. In this study celecoxib (20 mg/kg i.p) is used as a reference standard. This study stated organic tea as a promising neuroprotective agent or adjuvant to prevent AD.
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Susmita Sil,Kaushik Bhandari,Pritha Gupta,Rupsa Ghosh,Analava Mitra,Bijoy Chandra Ghosh,Tusharkanti Ghosh 경희대학교 융합한의과학연구소 2018 Oriental Pharmacy and Experimental Medicine Vol.18 No.1
India is the largest consumer of black tea in the world, which has been reported to have different protective functions in several diseases. TV 25 variety back tea has high content of polyphenols and has anti-oxidant potential. This anti-oxidant property of black tea (TV 25 variety) may prove to be effective in ameliorating the oxidative stress, neuroinflammation linked cognitive impairments and peripheral immune responses in intracerebroventricular colchicine injected rats (ICIR). However, there is no report in literature in this regard. Aim of the study: Therefore, this study has been designed to investigate the effects of black tea (BT) (TV 25 variety) on the colchicine induced cognitive impairments, acetylcholine esterase activity and peripheral immune responses along with oxidative/ nitrosative stress. The oxidative stress (OS)/ nitrosative stress (NS) and increased acetylcholine esterase level in the hippocampus of ICIR were associated with working and reference memory impairments along with changes of stress markers of serum and alteration of peripheral immune responses (higher phagocytic activity of blood WBC and splenic PMN, higher cytotoxicity and lower leukocyte adhesion inhibition index of splenic MNC). Administration of BT in ICIR resulted in recovery of colchicine induced memory impairments, acetylcholine esterase level in the hippocampus, OS and NS in hippocampus and serum along with recovery of peripheral immune responses and serum corticosterone level. Therefore, it appears that the anti-oxidant potential of BT (TV 25) is potent enough to protect the colchicine induced OS/ NS and related memory impairments in ICIR.
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