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RISS 인기검색어
- 검색키워드
- 저자 : Ana Laura de la Garza (검색결과 3 건)
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Helichrysum and Grapefruit Extracts Boost Weight Loss in Overweight Rats Reducing Inflammation
Ana Laura de la Garza,Usune Etxeberria,Alexander Haslberger,Eva Aumueller,J. Alfredo Martı´nez,Fermı´n I. Milagro 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.8
Obesity is characterized by an increased production of inflammatory markers. High levels of circulating free fatty acids and chronic inflammation lead to increased oxidative stress, contributing to the development of insulin resistance (IR). Recent studies have focused on the potential use of flavonoids for obesity management due to their antioxidant and antiinflammatory properties. This study was designed to investigate the antioxidant and anti-inflammatory effects of helichrysum and grapefruit extracts in overweight insulin-resistant rats. Thirty-eight male Wistar rats were randomly distributed in two groups: control group (n = 8) and high-fat sucrose (HFS) group (n = 30). After 22 days of ad libitum water and food access, the rats fed HFS diet changed to standard diet and were reassigned into three groups (n = 10 each group): nonsupplemented, helichrysum extract (2 g/kg bw), and grapefruit extract (1 g/kg bw) administered for 5 weeks. Rats supplemented with both extracts gained less body weight during the 5-week period of treatment, showed lower serum insulin levels and liver TBARS levels. Leptin/adiponectin ratio, as an indicator of IR, was lower in both extract-administered groups. These results were accompanied by a reduction in TNFα gene expression in epididymal adipose tissue and intestinal mucosa, and TLR2 expression in intestinal mucosa. Helichrysum and grapefruit extracts might be used as complement hypocaloric diets in weight loss treatment. Both extracts helped to reduce weight gain, hyperinsulinemia, and IR, improved inflammation markers, and decreased the HFS diet-induced oxidative stress in insulin-resistant rats.
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Bianca Romero-Delgado,Marcela Cárdenas-Tueme,José de Jesús Herrera-de la Rosa,Alberto Camacho-Morales,Heriberto Castro,Ana Laura de la Garza 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.8
Maternal high-sweetener diet, such as sucrose, has been associated with an increased risk of metabolic and cognitive-related diseases in the offspring. This study was performed to determine the effect of maternal sweetener intake during gestation and lactation on learning and memory in adult female offspring rats. Twenty-eight female pups from dams fed standard diet (Control-C, n = 10), high-sucrose diet (HS-C, n = 6), and high-honey diet (Ho-C, n = 12) were fed standard diet after weaning and body weight and food intake were recorded once a week for 19 weeks. Learning and memory tests were conducted at week 14 (Y-maze) and 18 (Barnes maze). We found that birth weight of Control-C group was greater than the Ho-C (P < .001). Blood glucose levels of the HS-C group were significantly higher than the Control-C and Ho-C groups. Control-C pups recognized the novel arm of the Y-maze compared with HS-C and Ho-C groups (P < .01). Also, offspring of the HS-C group showed deficient performance in the Barnes test when compared with the Control-C and Ho-C groups (P < .05). These results suggest that dams fed a high-sucrose diet during gestation and lactation favor high-glucose levels and deficient long-term memory performance in adult female offspring rats.
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Anael Mellado-Negrete,Gloria Itzel Peña-Vázquez,Vania Urías-Orona,Ana Laura de la Garza 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.8
Fruit by-products are a source of biocompounds with antioxidant properties and potential role in the obesitytreatment. This study aimed to assess the effect of pomegranate (Punica granatum) peel (PP) supplementation on the totalantioxidant capacity (TAC) in diet-induced obese rats. Thus, an in vitro gastrointestinal digestion was performed to evaluatethe total phenolic content (TPC) and the antioxidant capacity of PP. Moreover, 15 male Wistar rats were randomized into threegroups: control diet (CTL; 3.35 kcal/g), cafeteria (CAF) diet (3.72 kcal/g), and CAF diet supplemented with PP (CAF + PP;200 mg/kg body weight; 3.72 kcal/g). Serum TAC was analyzed by ferric reducing antioxidant power and 2,2-Diphenil-1-picrylhydrazil assay. TPC in PP accounted for 8.82 – 0.14 mg GAE/g in undigested samples. However, an in vitro digestionprocess was decreased by 94% the bioaccessibility of PP phenolic compounds in the intestinal phase, while PP supplementationincreased serum TAC in diet-induced obese rats. Therefore, although PP phenolic compounds diminished after anin vitro digestion process, antioxidant effect was found in obese rats supplemented with PP.
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