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Ana Flávia Seraine Custódio Viana,Hélio B Fernandes,Mariana H Chave,Daniel A Viana,Verlane G Santos,Ariadne C A Silva,Miriam T.P. Lopes,Rita de Cássia M Oliveira 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.3
Cenostigma macrophyllum Tul. var. acuminata Teles Freire (Leguminosae–Caesalpinioideae) is a medicinal plant traditionally used for treatment of gastric ulcer. This study evaluated the ulcer-healing activity of the hydroalcoholic fraction of C. macrophyllum Tul. var. acuminata Teles Freire leaves (Cm-FHA) and the tea of the leaves of C. macrophyllum (Cm-tea), as well as the possible action of Cm-FHA, through in vitro models. Leaves of C. macrophyllum were dried and powdered to obtain the Cm-FHA. Subsequently, the Cm-FHA was characterized phytochemically and biologically. Besides, Cm-tea was prepared. The gastric healing effects of Cm-tea and Cm-FHA were analyzed using the model of acetic acid-induced gastric ulcer in rats. The human gastric adenocarcinoma (AGS) cell line was employed as an in vitro model. Cm-tea promoted a protective effect against gastric ulcers induced by absolute ethanol. Cm-FHA or Cm-tea (100 mg/kg/7 days) exhibited a significant healing effect on ulcers induced by acetic acid. In the histological analysis, gastric mucosa treated with Cm-FHA or Cm-tea advanced restoration of the mucosal epithelium. In vitro, lower concentrations of Cm-FHA stimulated cell proliferation in the BrdU assay and cell migration. Cm-tea and Cm-FHA present a significant gastric healing effect in in vivo and in vitro models.
Modeling refractory concrete lining of fluid catalytic cracking units of oil refineries
Ana B.C.G. Silva,Henrique C.C. Andrade,Eduardo M.R. Fairbairn,Jose C.F. Telles,Fernando L.B. Ribeiro,Romildo D. Toledo-Filho,Jorivaldo Medeiros 사단법인 한국계산역학회 2020 Computers and Concrete, An International Journal Vol.25 No.1
This work presents a numerical modeling procedure to simulate the refractory concrete lining in fluid catalytic cracking units of oil refineries. The model includes the simulation of the anchors that reinforce the contact between the refractory concrete and the steel casing. For this purpose, the constitutive relations of an interface finite element are set to values that represent the homogenized behavior of the anchored interface. The parameters of this constitutive relation can be obtained by experimental tests. The model includes also multi-surface plasticity, in order to represent the behavior of the refractory concrete lining. Since the complexity of real case applications leads to high computational costs, the models presented here were implemented in a high-performance parallelized finite element platform. A case study representing a riser similar to the ones used by the refinery industry demonstrates the potential of the model.
A general tangent operator applied to concrete using a multi-surface plasticity model
Ana Beatriz C.G. Silva,Jose Claudio F. Telles,Eduardo M.R. Fairbairn,Fernando Luiz B. Ribeiro 사단법인 한국계산역학회 2015 Computers and Concrete, An International Journal Vol.16 No.2
The present paper aims at developing a method to accommodate multi-surface concrete plasticity from the point of view of a consistency concept applied to general tangent operators. The idea is based on a Taylor series expansion of the actual effective stress at the stress point corresponding to the previous accumulated true stresses plus the current increment values, initially taken to be elastic. The proposed algorithm can be generalized for any multi-surface criteria combination and has been tested here for typical cement-based materials. A few examples of application are presented to demonstrate the effectiveness of the multi-surface technique as used to a combination of Rankine and Drucker-Prager yield criteria.