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Bioactive phytochemicals that regulate the cellular processes involved in diabetic nephropathy
Parveen, Amna,Jin, Mirim,Kim, Sun Yeou Elsevier 2018 Phytomedicine Vol.39 No.-
<P>Conclusion: Based on various experimental studies, traditional herbs and their bioactive constituents regulate the cellular processes involved in the initiation of DN owing to their significant pharmacological activities; however, the efficacy in animal models and humans has not yet been explored. Therefore, studies should be performed to evaluate the nephroprotective effects of medicinal plants in preclinical animal models and in humans.</P>
Amna Parveen,Razia Sultana,Seung Min Lee,김태훈,김선연 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.4
The role of advanced glycation end products(AGEs) is not limited to diabetes and diabetes-related complications. There are multiple modulators, including thereceptor for advanced glycation end products, high mobilitygroup box 1, glyoxalase 1, nuclear factor-kappa B, tumornecrosis factor-α, chronic unpredictable stress, reactiveoxygen species, and infl ammatory cytokines, which interactwith AGE signaling and control diabetes, modulatingthese interacting modulators. The progression of diabetes,as well as related complications, can be controlled andtreated. Natural products rich in bioactive constituents caninteract with AGEs and their related mediators through varioussignaling cascades, thereby controlling and preventingthe progression of diabetes. This review provides a deeperassessment of the signaling pathway, interactions betweenphytochemicals and AGEs, and its mediators, to develop a multifold therapeutic approach to prevent and treat diabetesand its related complications.
Cho, KyoHee,Parveen, Amna,Kang, Min Cheol,Subedi, Lalita,Lee, Jae Hyuk,Park, Sun Young,Jin, Mi Rim,Yoon, Hyeokjun,Son, Youn Kyoung,Kim, Sun Yeou Elsevier 2018 Phytomedicine Vol.48 No.-
<P>Conclusion: Our studies indicate that PUL ameliorates atopic dermatitis-like symptoms by suppressing the proinflammatory cytokines and immune stimuli in both in vitro and in vivo animal models. Therefore, these data suggest that PUL might be an effective natural resource for the treatment of AD.</P>
Lee, Jae Hyuk,Parveen, Amna,Do, Moon Ho,Lim, Yunsook,Shim, Sang Hee,Kim, Sun Yeou Elsevier 2018 Phytomedicine Vol.48 No.-
<P>Conclusion: Our findings suggest that LCE increase NO production via eNOS phosphorylation of PI3K/Akt signaling pathway.</P>
Sultan, Sadia,Irfan, Syed Mohammed,Parveen, Saira,Haider, Syeda Amna,Masood, Mahira Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.4
Background: Hodgkin's lymphoma (formerly, Hodgkins disease) is a potentially curable malignancy with distinctive biological behavior and specific clinical characteristics. Limited information is available from developing countries for patients with classical Hodgkin's lymphoma (cHL). Therefore we reviewed the demographical and clinico-hematological profiles along with bone marrow infiltration patterns in adult patients presenting at Liaquat National Hospital and Medical College. Materials and Methods: In this cross sectional study, 62 adult (${\geq}15years$) patients with cHL were enrolled from January 2010 to December 2014. Results: The mean age was $29.7{\pm}13.8years$ with a median of 30 years. The male to female ratio was 2:1. B symptoms were present in 72.5% of patients and lymph node enlargement in 85.4%. The frequency of bone marrow infiltration in our cHL patients was found to be 27.4%, the pattern being predominantly focal followed by diffuse. The mean hemoglobin was $9.4{\pm}1.9g/dl$ with a mean MCV of $78.1{\pm}7.9fl$, a mean total leukocyte count of $10.9{\pm}20.6{\times}10^9/l$ and a mean platelet count of $241.6{\pm}150.1{\times}10^9/l$. Conclusions: Our analysis shows that clinico-pathological features of cHL in Pakistan are comparable to published data. Peripheral lymphodenopathy associated with B symptoms is the commonest presentation. Bone marrow involvement is more common in our setup as patients usually presented at an advanced stage of disease.