Preventive Effect of Probiotics and α-Tocopherol on Ethanol-Induced Gastric Mucosal Injury in Rats

Altug Senol,Mehmet Isler,Aynur G. Karahan,Gulden B. Kilic,Hakan Kuleasan,Selcuk Kaya,Muharrem Keskin,Ibrahim Goren,Ulku Saritas,Buket C. Aridogan,Namik Delibas 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.1

The protective effect of a probiotic mixture of 13 different bacteria and α-tocopherol on 98% ethanol-induced gastric mucosal injury was evaluated. Levels of gastric mucosal pro- and anti-inflammatory cytokines, malondialdehyde, and secretory immunglobulin A were measured. Rats were allocated into four groups: control, ethanol, probiotic, and α-tocopherol. The control and ethanol groups received skim milk for 14 days. Probiotic and α-tocopherol groups were administered probiotic mixture suspended in skim milk and 100mg/kg α-tocopherol, respectively, by daily gavage for 14 days. On Day 15, gastric lesions were induced by administration of ethanol 98% (1mL) to all rats except those in the control group. Probiotic, but not α-tocopherol, seemed to inhibit ethanol-induced gastric mucosal tumor necrosis factor-α, interferon-γ, and interleukin-2 production (P>.05). Ethanol caused the elevation of mucosal interleukin-4 level (compared to the control, P<.05). Probiotic pretreatment significantly suppressed the ethanol-induced increase of gastric mucosal interleukin-4 levels. Pretreatment with either probiotic or α-tocopherol inhibited the ethanol-induced increase of mucosal malondialdehyde concentration (P<.01 and P<.05, respectively). Probiotic pretreatment enhanced the gastric mucosal secretory immunoglobulin A concentration (P<.001). In conclusion, probiotic mixture and α-tocopherol reduced ethanol-induced gastric mucosal lipid peroxidation, suggesting that they may be beneficial for gastric lesions induced by lower ethanol concentration.

In vitro comparison of two different materials for the repair of urethan dimethacrylate denture bases

Cilingir, Altug,Bilhan, Hakan,Geckili, Onur,Sulun, Tonguc,Bozdag, Ergun,Sunbuloglu, Emin The Korean Academy of Prosthodonitics 2013 The Journal of Advanced Prosthodontics Vol.5 No.4

PURPOSE. The purpose of this in vitro study was to investigate the flexural properties of a recently introduced urethane dimethacrylate denture base material (Eclipse) after being repaired with two different materials. MATERIALS AND METHODS. Two repair groups and a control group consisting of 10 specimens each were generated. The ES group was repaired with auto-polymerizing polymer. The EE group was repaired with the Eclipse. The E group was left intact as a control group. A 3-point bending test device which was set to travel at a crosshead speed of 5 mm/min was used. Specimens were loaded until fracture occurred and the mean displacement, maximum load, flexural modulus and flexural strength values and standard deviations were calculated for each group and the data were statistically analyzed. The results were assessed at a significance level of P<.05. RESULTS. The mean "displacement", "maximum load before fracture", flexural strength" and "flexural modulus" rates of Group E were statistically significant higher than those of Groups ES and EE, but no significant difference (P>.05) was found between the mean values of Group ES and EE. There was a statistically significant positive relation (P<.01) between the displacement and maximum load of Group ES (99.5%), Group EE (94.3%) and Group E (84.4%). CONCLUSION. The more economic and commonly used self-curing acrylic resin can be recommended as an alternative repair material for Eclipse denture bases.

The impact of frenulum height on strains in maxillary denture bases

Cilingir, Altug,Bilhan, Hakan,Baysal, Gokhan,Sunbuloglu, Emin,Bozdag, Ergun The Korean Academy of Prosthodonitics 2013 The Journal of Advanced Prosthodontics Vol.5 No.4

PURPOSE. The midline fracture of maxillary complete dentures is a frequently encountered complication. The purpose of this study was to assess the effect of frenulum height on midline strains of maxillary complete dentures. MATERIALS AND METHODS. A removable maxillary complete denture was fabricated and duplicated seven times. Four different labial frenulum heights were tested for stresses occurring on the palatal cameo surface. The strains were measured with strain gauges placed on 5 different locations and the stresses were calculated. To mimic occlusal forces bilaterally 100 N of load was applied from the premolar and molar region. RESULTS. A statistically significant association between the height of the labial frenulum and the calculated stresses and strains was shown (P<.05) predominantly on the midline and especially on the incisive papilla. The results showed that stress on the anterior midline of the maxillary complete denture increases with a higher labial frenulum. CONCLUSION. Within the limitations of this in vitro study, it can be concluded that the stress on the anterior midline of the maxillary complete denture increases with a higher labial frenulum. Surgical or mechanical precautions should be taken to prevent short-term failure of maxillary complete dentures due to stress concentration and low cycle fatigue tendency at the labial frenulum region.

Late development of a mandibular second premolar

Ali Altug Bicakci,Cenk Doruk,Hasan Babacan 대한치과교정학회 2012 대한치과교정학회지 Vol.42 No.2

In this report, we present the case of a girl with delayed odontogenesis of a lower second premolar for which she was followed up for 8.5 years. Congenital absence of permanent mandibular second premolars was observed at the initial radiographic examination at 8 years and 1 month. One year later, during the treatment period, an unexpected odontogenesis of a right second premolar was diagnosed on follow-up radiography. The original treatment plan was revised and a new plan was successfully implemented. This unusual case showed that the orthodontist’s clinical philosophy must be flexible because unexpected situations can arise, especially when treating growing patients.

Late development of a mandibular second premolar

Bicakci, Ali Altug,Doruk, Cenk,Babacan, Hasan The Korean Association Of Orthodontists 2012 대한치과교정학회지 Vol.42 No.2

In this report, we present the case of a girl with delayed odontogenesis of a lower second premolar for which she was followed up for 8.5 years. Congenital absence of permanent mandibular second premolars was observed at the initial radiographic examination at 8 years and 1 month. One year later, during the treatment period, an unexpected odontogenesis of a right second premolar was diagnosed on follow-up radiography. The original treatment plan was revised and a new plan was successfully implemented. This unusual case showed that the orthodontist's clinical philosophy must be flexible because unexpected situations can arise, especially when treating growing patients.

Flexural properties of a light-cure and a self-cure denture base materials compared to conventional alternatives

Emre Mumcu,Altug Cilingir,Burc Gencel,Tonguc S?l?n 대한치과보철학회 2011 The Journal of Advanced Prosthodontics Vol.3 No.3

PURPOSE A new light curing urethane dimethacrylate and a cold curing resin with simpler and faster laboratory procedures may have even improved flexural properties. This study investigated the 3-point flexural strengths and flexural moduli of two alternate base materials. MATERIALS AND METHODS A cold curing resin (Weropress) and a light curing urethane dimethacrylate base material (Eclipse). Along with Eclipse and Weropress, a high impact resin (Lucitone199) and three conventional base materials (QC 20, Meliodent and Paladent 20) were tested. A 3-point bending test was used to determine the flexural strengths and flexural moduli. The mean displacement, maximum load, flexural modulus and flexural strength values and standard deviations for each group were analyzed by means of one-way analysis of variance (ANOVA) (with mean difference significant at the 0.05 level). Post hoc analyses (Scheffe test) were carried out to determine the differences between the groups at a confidence level of 95%. RESULTS Flexural strength, displacement and force maximum load values of Eclipse were significantly different from other base materials. Displacement values of QC 20 were significantly different from Lucitone 199 and Weropress. CONCLUSION The flexural properties and simpler processing technique of Eclipse system presents an advantageous alternative to conventional base resins and Weropress offers another simple laboratory technique.

Effectiveness of low-level laser therapy and chewing gum in reducing orthodontic pain: A randomized controlled trial

Fatih Celebi,Ali Altug Bicakci,Ufuk Kelesoglu 대한치과교정학회 2021 대한치과교정학회지 Vol.51 No.5

Objective: The purpose of this study was to evaluate the effects of chewing gum and low-level laser therapy in alleviating orthodontic pain induced by the initial archwire. Methods: Patients with 3–6 mm maxillary crowding who planned to receive non-extraction orthodontic treatment were recruited for the study. Sixty-three participants (33 females and 30 males) were randomly allocated into three groups: laser, chewing gum, and control. In the laser group, a gallium aluminum arsenide (GaAlAs) diode laser with a wavelength of 820 nm was used to apply a single dose immediately after orthodontic treatment began. In the chewing gum group, sugar-free gum was chewed three times for 20 minutes— immediately after starting treatment, and at the twenty-fourth and forty-eighth hours of treatment. Pain perception was measured using a visual analog scale at the second, sixth, and twenty-fourth hours, and on the second, third, and seventh days. Results: There were no statistically significant differences between the groups at any measured time point (p > 0.05). The highest pain scores were detected at the twenty-fourth hour of treatment in all groups. Conclusions: Within the limitations of the study, we could not detect whether low-level laser therapy and chewing gum had any clinically significant effect on orthodontic pain. Different results may be obtained with a higher number of participants or using lasers with different wavelengths and specifications. Although the study had a sufficient number of participants according to statistical analysis, higher number of participants could have provided more definitive outcomes.

Noncompliance screw supported maxillary molar distalization in a parallel manner

Nalcaci, Ruhi,Bicakci, Ali Altug,Ozan, Fatih The Korean Association Of Orthodontists 2010 대한치과교정학회지 Vol.40 No.4

상악 구치의 후방이동을 위한 구강 내 장치 중 환자의 협조를 필요로 하지 않는 방법은 제II급 부정교합의 개선에 성공적으로 널리 사용되고 있다. 본 연구는 스크류에 의해 지지되는 구강 내 후방이동 장치를 소개하고 그 효율성을 조사하고자 하였다. Angle Class II 부정교합으로 진단된 21명의 환자(여자 11명, 남자 10명; 평균 연령 14.9세)를 대상으로 하였다. 2개의 스크류를 incisive foramen 후방에 식립하고, 식립한 즉시 힘을 주어 상악 제1대구치의 후방이동에 사용하였다. 상악 구치를 후방이동시켜 제I급 구치관계를 얻기 위해 스크류에 의해 지지되는 구강 내 후방이동 장치를 사용하였다. 치료 전후 측모두부 방사선 사진과 3차원 모델 분석을 통해 골격 및 치아의 변화를 평가하였다. 연구결과 상악 구치는 평균 3.95 mm 후방이동하였고, 추가적인 고정원 소실 없이 제I급 구치관계를 확립하였다. 상악 대구치는 $1.49^{\circ}$ 후방경사 되었고, 회전된 정도는 좌우 각각 $0.74^{\circ}$, $0.54^{\circ}$으로 통계적으로 유의성 있는 변화를 보이지 않았다 (p > 0.05). 새롭게 고안된 장치는 스크류에 의해 지지되어 환자의 협조도를 요하지 않으며 특별한 고정원 소실 없이 구치의 치체이동을 통한 후방이동을 얻는 데 효과적인 것으로 판단된다. Objective: Intraoral noncompliance upper molar distalization techniques have gained in popularity and have subsequently found to be successful in Class II correction. The aim of the present study was to introduce a screw supported intraoral distalization appliance and investigate its efficiency. Methods: Twenty-one subjects (11 females, 10 males; average age of 14.9 years) with Angle Class II malocclusion participated in this study. Two screws were inserted behind the incisive foramen and immediately loaded to distalize the upper first molars. An intraoral screw supported distalization appliance was used to distalize the upper molars in order to achieve a Class I molar relationship. Skeletal and dental changes were evaluated using cephalometric and three-dimensional (3D) model analysis. Results: Upper molars were distalized 3.95 mm on average and a Class I molar relationship was achieved without any anchorage loss. The upper molars were tipped only $1.49^{\circ}$ and the upper right and left molars were rotated only $0.54^{\circ}$ and $0.74^{\circ}$ respectively which were statistically non-significant (p > 0.05). Conclusions: The newly designed screw supported noncompliance distalization appliance was found to be an effective device for achieving bodily molar distalization without any anchorage loss.

Discrete singular convolution for buckling analyses of plates and columns

Civalek, Omer,Yavas, Altug Techno-Press 2008 Structural Engineering and Mechanics, An Int'l Jou Vol.29 No.3

In the present study, the discrete singular convolution (DSC) method is developed for buckling analysis of columns and thin plates having different geometries. Regularized Shannon's delta (RSD) kernel is selected as singular convolution to illustrate the present algorithm. In the proposed approach, the derivatives in both the governing equations and the boundary conditions are discretized by the method of DSC. The results obtained by DSC method were compared with those obtained by the other numerical and analytical methods.

Noncompliance screw supported maxillary molar distalization in a parallel manner

Ruhi Nalc¸aci,Ali Altug˘ Bic¸akci,Fatih Ozan 대한치과교정학회 2010 대한치과교정학회지 Vol.40 No.4

Objective: Intraoral noncompliance upper molar distalization techniques have gained in popularity and have subsequently found to be successful in ClassⅡ correction. The aim of the present study was to introduce a screw supported intraoral distalization appliance and investigate its efficiency. Methods: Twenty-one subjects (11 females, 10 males; average age of 14.9 years) with Angle ClassⅡ malocclusion participated in this study. Two screws were inserted behind the incisive foramen and immediately loaded to distalize the upper first molars. An intraoral screw supported distalization appliance was used to distalize the upper molars in order to achieve a ClassⅠ molar relationship. Skeletal and dental changes were evaluated using cephalometric and three-dimensional (3D) model analysis. Results: Upper molars were distalized 3.95 mm on average and a ClassⅠ molar relationship was achieved without any anchorage loss. The upper molars were tipped only and the upper right and left molars were rotated only 1.49˚ and the upper right and left molars were rotated only 0.54˚ and 0.74˚ respectively which were statistically non-significant (p > 0.05). Conclusions: The newly designed screw supported noncompliance distalization appliance was found to be an effective device for achieving bodily molar distalization without any anchorage loss. 상악 구치의 후방이동을 위한 구강 내 장치 중 환자의 협조를 필요로 하지 않는 방법은 제Ⅱ급 부정교합의 개선에 성공적으로 널리 사용되고 있다. 본 연구는 스크류에 의해 지지되는 구강 내 후방이동 장치를 소개하고 그 효율성을 조사하고자 하였다. Angle ClassⅡ 부정교합으로 진단된 21명의 환자(여자 11명, 남자 10명; 평균 연령 14.9세)를 대상으로 하였다. 2개의 스크류를 incisive foramen 후방에 식립하고, 식립한 즉시 힘을 주어 상악 제1대구치의 후방이동에 사용하였다. 상악 구치를 후방이동시켜 제Ⅰ급 구치관계를 얻기 위해 스크류에 의해 지지되는 구강 내 후방이동 장치를 사용하였다. 치료 전후 측모두부 방사선 사진과 3차원 모델 분석을 통해 골격 및 치아의 변화를 평가하였다. 연구결과 상악 구치는 평균 3.95 mm 후방이동하였고, 추가적인 고정원 소실 없이 제Ⅰ급 구치관계를 확립하였다. 상악 대구치는 1.49˚후방경사 되었고, 회전된 정도는 좌우 각각 0.54˚, 0.74˚ 으로 통계적으로 유의성 있는 변화를 보이지 않았다 (p > 0.05). 새롭게 고안된 장치는 스크류에 의해 지지되어 환자의 협조도를 요하지 않으며 특별한 고정원 소실 없이 구치의 치체이동을 통한 후방이동을 얻는데 효과적인 것으로 판단된다.