Evaluation of prophylactic and therapeutic effects of ruscogenin on acute radiation proctitis

Erkan Yavuz,Onur Olgac Karagulle,Gulcin Ercan,Atilla Celik,Hakan Yigitbas,Busra Yaprak Bayrak,Rumeysa Tartar,Ramazan Kusaslan,Yuksel Altine,Osman Bilgin Gulcicek 대한외과학회 2018 Annals of Surgical Treatment and Research(ASRT) Vol.94 No.4

Purpose: Radiation proctitis (RP) is inflammation and damage to the rectum, manifested secondary to ionizing radiation utilized for treatment. In this study, we evaluated the anti-inflammatory therapeutical and protective effects of ruscogenin in a model of acute RP. Methods: Thirty-two Sprague-Dawley rats were divided into 4 groups (n = 8) as sham, control, treatment, and prophylaxis groups. Prophylaxis group and treatment group were dosed ruscogenin by oral gavage for 14 days pre- and postradiation. At the end of the 28th day, all subjects were sacrificed. Results: Histopathological analysis showed a significant increase in cryptitis abscess, cryptitis and reactive atypia, and depth of lymphocytic infiltration of the control group, compared to the other groups (P < 0.05), while treatment and prophylaxis groups showed significant decreases (P < 0.05). Immunohistochemical analysis indicated that immunoreactivity were significantly higher in control group (P < 0.05, P < 0.001, and P < 0.01, respectively), but vice versa for treatment and prophylaxis groups. There was not any significant difference for fibroblast growth factor 2 immunoreactivity. The epithelium of control rectums indicated an increase in TNF-α immunoreactivity while other groups had significant decrease (P < 0.01). Electron microscopical findings were parallel to light microscopy. Conclusion: In this study, ruscogenin was observed to be effective on prophylaxis or treatment of acute RP. Although there are various reports on the treatment of the rectum damaged by acute RP in the literature, this could be the first study since there is no research indicating the ultrastructural effect of ruscogenin.

Separation of Cd(II) from Aqueous Solutions by A New Consecutive Process Consisting of Supported Liquid Membrane and Electrodialysis

Altin, Sureyya,Altin, Ahmet The Korean Electrochemical Society 2019 Journal of electrochemical science and technology Vol.10 No.1

Supported liquid membrane process usually is used for recovering or enrichment of valuable metals in the industrial wastewater. But, even if the metals in the wastewater was separated with high chemical selectivity, it cannot be enough concentrated since separation performance of supported liquid membrane (SLM) process is limited by concentration gradient between feed solution and stripping solution. If metal concentration in the stripping solution to be enough low, transport of metal through membrane can be accomplishment constantly. Therefore, Electrodialysis (ED) has been placed after SLM process and the stripping solution of SLM was used as the feed solution for the ED process. Transport of ions in the solutions is successfully performed by ED process. Thus, the metal concentration in the stripping solution does not rise as to stop ion transport. Besides, valuable metals easily are concentrated by ED process for re-use. In this study, effects of operation parameters like initial Cd(II) concentration, HCl concentration in the feed solution of SLM and applied voltage are investigated on separation efficiency, flux and permeability of the both processes. As the feed solution concentration increased, all performance values has increased. When initial concentration of 100 mg/L is used, separation performances (SP) are 55% and 70%, for SLM and consecutive process, respectively. The best HCl concentration in the feed solution of SLM has determined as 2 M, in this conditions SP are 64% and 72%, for SLM and consecutive process, respectively. With increased of applied voltage on ED process, SP of the consecutive process has been raised from 72% to 83%. According to the obtained experimental data, consecutive process has better separation performance than SLM. When the separation performances of both processes were compared for the same operating conditions, it was determined higher the separation efficiency, permeability and flux values of the consecutive process, 8%, 9% and %10.6, respectively. Consequently, the use of the consecutive process increases the performance efficiency of both processes. The consecutive process studied has quite a good chemical separation efficiency, and enrichment capability. Moreover, this process requires few water and energy.

RULED SURFACES IN E³ WITH DENSITY

Altin, Mustafa,Kazan, Ahmet,Karadag, H.Bayram The Honam Mathematical Society 2019 호남수학학술지 Vol.41 No.4

In the present paper, we study curves in 𝔼³ with density $e^{ax^2+by^2}$, where a, b ∈ ℝ not all zero constants and give the parametric expressions of the curves with vanishing weighted curvature. Also, we create ruled surfaces whose base curves are the curve with vanishing weighted curvature and the ruling curves are Smarandache curves of this curve. Then, we give some characterizations about these ruled surfaces by obtaining the mean curvatures, Gaussian curvatures, distribution parameters and striction curves of them.

A NOTE ON LACUNARY STATISTICALLY CONVERGENT DOUBLE SEQUENCES OF FUZZY NUMBERS

Altin, Yavuz Korean Mathematical Society 2008 대한수학회논문집 Vol.23 No.2

In this paper we introduce and study lacunary statistical convergence for double sequences of fuzzy numbers and we shall also present some inclusion theorems.

Rehabilitation of heavily earthquake damaged masonry building using steel straps

Altin, Sinan,Kuran, Fikret,Anil, Ozgur,Kara, M. Emin Techno-Press 2008 Structural Engineering and Mechanics, An Int'l Jou Vol.30 No.6

The purpose of this study is to develop a rehabilitation technique for heavily earthquake damaged masonry buildings. A full scale one storey masonry building with window and door openings was manufactured and tested on the shock table by applying increased amplitude free vibration up to the point where heavy earthquake damage was observed. Damaged test building was rehabilitated with vertical and diagonal steel straps and then tested again. The effectiveness of improvements obtained by the rehabilitation technique was investigated. Steel straps improved the lateral strength and stiffness of masonry walls and limited the lateral displacement of building. Stability of the masonry walls were also improved by the steel straps. Steel straps reduced the natural period of the earthquake damaged masonry building and prevented the failure of the building at the same amplitude of free vibration.

Evaluation of autochthonous Lactococcus lactis subsp. lactis strain as a candidate starter culture in white-brined cheese

Cansu Altin,Tijjani Ismail Kabwanga,Fadime Kiran,Sebnem Ozturkoglu-Budak 한국식품과학회 2024 Food Science and Biotechnology Vol.33 No.1

Lactococcus lactis subsp. lactis NCCB100539 isolated from an artisanal raw ewe’s milk cheese was evaluated as a potential starter culture in white-brined cheese. As a safety criteria, the cytotoxicity of the viable and heat-killed cells and CFE of this strain were determined on Caco-2 cell line by MTT assay. The antibiotic sensitivity of the strain to nine different antibiotics was also investigated. Cheeses produced using this strain were compared with control cheese in terms of physicochemical, microbiological, sensory properties as well as the peptide and volatile profiles during the 90-days of ripening period. Experimental cheeses had more extensive proteolysis as well as higher sensory scores. Incorporated L. lactis also led to an improvement in the microbial cheese quality. Neither living nor the dead cells and CFE of the strain showed cytotoxicity on Caco-2 cells. Therefore, L. lactis NCCB100539 strain could be a good starter candidate for the industrial white-brined cheeses.

Thermal conductivity and magnetic properties of the B substituted Ca3Co4O9

S. Altin,A. Bayri,S. Demirel,M.A. Aksan 한국물리학회 2014 Current Applied Physics Vol.14 No.4

In this study, we reported the effects of the boron (B) substitution into the Ca site in the Ca3Co4O9 system on the electrical, thermal and magnetic properties between 300 K and 5 K. The results indicated that the B-substitution into the system caused an increase of resistivity due to the decrease on carrier concentration. Thermal conductivity decreased for the x ¼ 0.5 B-substituted sample and then increased with increasing the B-content. Analysis on the thermal conductivity of samples showed that the phonon ephonon interaction term is the dominant component in the total thermal conductivity for all the samples. It was found that the point defect contribution to the thermal conductivity increased by increasing the B-content. The temperature dependence of magnetic susceptibility showed a paramagnetic behavior at room temperature and ferrimagnetic behavior below 20 K for unsubstituted sample. But, the magnetization decreased in the B-substituted samples. The substitution of B into the Ca site destroyed the interlayer coupling, which resulted in the decrease of the ferromagnetic behavior. The susceptibility data was fitted using CurieeWeiss law with temperature independent term and the meff values were calculated to be 1.42 mB and 3.89 mB for unsubstituted sample and the highest B-substitution, respectively.

Rehabilitation of heavily earthquake damaged masonry building using steel straps

Sinan Altin,Fikret Kuran,Özgür Anil,M. Emin Kara 국제구조공학회 2008 Structural Engineering and Mechanics, An Int'l Jou Vol.30 No.6

The purpose of this study is to develop a rehabilitation technique for heavily earthquake damaged masonry buildings. A full scale one storey masonry building with window and door openings was manufactured and tested on the shock table by applying increased amplitude free vibration up to the point where heavy earthquake damage was observed. Damaged test building was rehabilitated with vertical and diagonal steel straps and then tested again. The effectiveness of improvements obtained by the rehabilitation technique was investigated. Steel straps improved the lateral strength and stiffness of masonry walls and limited the lateral displacement of building. Stability of the masonry walls were also improved by the steel straps. Steel straps reduced the natural period of the earthquake damaged masonry building and prevented the failure of the building at the same amplitude of free vibration.

The Effect of Various Sowing Rate and Row Distance on Yield and Yield Components of chickling Vetch ( Lathyrus sativus L. ) in Thrace Region, Turkey

Murat Altin,Adnan Orak,Taylan Aksoy 한국초지조사료학회 2000 한국초지조사료학회지 Vol.20 No.2

MgB2 thin film fabrication with excess Mg by sequential e-beam evaporation and transport properties under magnetic fields

E. Altin,F. Kurt,S. Altin,M.E. Yakinci,Z.D. Yakinci 한국물리학회 2014 Current Applied Physics Vol.14 No.3

Superconducting MgB2 thin films with different thicknesses were fabricated by excess Mg using sequential electron beam evaporation technique. The flux rate of Mg and B were chosen as 3 nm/sn and 0.5 nm/sn respectively. The thickness of Mg/B layer was determined as 3/1 which causes an excess Mg for MgB2 formation. After two-step preparation process, the superconducting transition temperatures were found in the range of 32e37 K with a sharp transition to zero resistance state. The irreversibility fields, upper critical fields and activation energies were derived from magneto resistivity curves. The transport critical current densities of films were determined from IeV characteristics under different applied fields and the data was extrapolated for determination of value of the 0 K.