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- 저자 : Alparslan Kadir Devrim (검색결과 1 건)
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Protective effects of silymarin on fumonisin B1-induced hepatotoxicity in mice
Mahmut Sozmen,Alparslan Kadir Devrim,Recai Tunca,Murat Bayezit,Serpil Dag,Dinc Essiz 대한수의학회 2014 Journal of Veterinary Science Vol.15 No.1
The present study was conducted to investigate the effect ofsilymarin on experimental liver toxication induced byFumonisin B1 (FB1) in BALB/c mice. The mice were dividedinto six groups (n = 15). Group 1 served as the control. Group2 was the silymarin control (100 mg/kg by gavage). Groups 3and 4 were treated with FB1 (Group 3, 1.5 mg/kg FB1,intraperitoneally; and Group 4, 4.5 mg/kg FB1). Group 5received FB1 (1.5 mg/kg) and silymarin (100 mg/kg), andGroup 6 was given a higher dose of FB1 (4.5 mg/kg FB1) withsilymarin (100 mg/kg). Silymarin treatment significantlydecreased (p < 0.0001) the apoptotic rate. FB1 administrationsignificantly increased (p < 0.0001) proliferating cell nuclearantigen and Ki-67 expression. Furthermore, FB1 elevated thelevels of caspase-8 and tumor necrosis factor-alpha mediatorswhile silymarin significantly reduced (p < 0.0001) theexpression of these factors. Vascular endothelial growthfactor (VEGF) and fibroblast growth factor-2 (FGF-2)expressions were significantly elevated in Group 4 (p <0.0001). Silymarin administration alleviated increased VEGFand FGF-2 expression levels (p < 0.0001). In conclusion,silymarin ameliorated toxic liver damage caused by FB1 inBALB/c mice.
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