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RISS 인기검색어
- 검색키워드
- 저자 : Allen M. Chen (검색결과 4 건)
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Are Efficient and Inefficient Farms Heterogeneous? Evidence from Kansas Farms
김영준,Bowen Chen,Allen M. Featherstone,Dustin L. Pendell 한국농업경제학회 2023 農業經濟硏究 Vol.64 No.1
Most of the previous literature on efficiency assumes that efficient and inefficient farms are homogeneous in production, even though they may have different strategies to increase efficiency. Exploiting Super Data envelopment analysis (DEA) and quantile regression, this study examines the sources of efficiency with particular consideration of the heterogeneity between efficient and inefficient farms using a farm-level dataset. The results show that an increase in some farm characteristics, such as the number of beef cows, percentage of income from beef cows, and percentage of acres owned, affects efficiency in different ways for efficient and inefficient farms. These results imply that efficient and inefficient farms are heterogeneous in terms of how farm characteristics affect efficiency.
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CHARGE TRANSPORT THROUGH CARBON NANOTUBE OR FULLERENE–MOLECULE–SILICON JUNCTIONS
FU-REN F. FAN,BO CHEN,AUSTEN K. FLATT,JAMES M. TOUR,ALLEN J. BARD 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2007 NANO Vol.2 No.5
We report here the current–voltage (i–V) characteristics of several (n++-Si/MNOPE/C60/Pt-tip) or (n++-Si/MNOPE/SWCNT/Pt-tip) junctions, where MNOPE = 2'-mononitro-4, 4'-bis(phenylethynyl)-1-phenylenediazonium and SWCNT = single wall carbon nanotube. A layer of C60 or SWCNT-derivatized MNOPE has strong effect on the i–V behavior of the junctions, including rectification, negative differential resistance (NDR) and switching behaviors. The i–V curve of a grafted molecular monolayer (GMM) of MNOPE atop n++-Si shows NDR behavior, whereas those of C60- and SWCNT-derivatized GMMs of MNOPE on n++-Si show strong rectifying behavior with opposite rectification polarities. With C60, larger currents were found with negative tip bias, while with SWCNT, the forward top bias was positive. Because C60 tends to be a good electron acceptor and SWCNTs tend to be good electron donors, they show different i–V behavior, as observed. Some of the (n++-Si/MNOPE/SWCNT/Pt-tip) junctions also show reversible bistable switching behavior.
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Detection of Rare Mutations in EGFR-ARMS-PCR-Negative Lung Adenocarcinoma by Sanger Sequencing
Chaoyue Liang,Zhuolin Wu,Xiaohong Gan,Yuanbin Liu,You You,Chenxian Liu,Chengzhi Zhou,Ying Liang,Haiyun Mo,Allen M. Chen,Jiexia Zhang 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.1
Purpose: This study aimed to identify potential epidermal growth factor receptor (EGFR) gene mutations in non-small cell lung cancer that went undetected by amplification refractory mutation system-Scorpion real-time PCR (ARMS-PCR). Materials and Methods: A total of 200 specimens were obtained from the First Affiliated Hospital of Guangzhou Medical University from August 2014 to August 2015. In total, 100 ARMS-negative and 100 ARMS-positive specimens were evaluated for EGFR gene mutations by Sanger sequencing. The methodology and sensitivity of each method and the outcomes of EGFR-tyrosine kinase inhibitor (TKI) therapy were analyzed. Results: Among the 100 ARMS-PCR-positive samples, 90 were positive by Sanger sequencing, while 10 cases were considered negative, because the mutation abundance was less than 10%. Among the 100 negative cases, three were positive for a rare EGFR mutation by Sanger sequencing. In the curative effect analysis of EGFR-TKIs, the progression-free survival (PFS) analysis based on ARMS and Sanger sequencing results showed no difference. However, the PFS of patients with a high abundance of EGFR mutationwas 12.4 months [95% confidence interval (CI), 11.6−12.4 months], which was significantly higher than that of patients with a low abundance of mutations detected by Sanger sequencing (95% CI, 10.7−11.3 months) (p<0.001). Conclusion: The ARMS method demonstrated higher sensitivity than Sanger sequencing, but was prone to missing mutations due to primer design. Sanger sequencing was able to detect rare EGFR mutations and deemed applicable for confirming EGFR status. A clinical trial evaluating the efficacy of EGFR-TKIs in patients with rare EGFR mutations is needed.
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A community computational challenge to predict the activity of pairs of compounds
Bansal, Mukesh,Yang, Jichen,Karan, Charles,Menden, Michael P,Costello, James C,Tang, Hao,Xiao, Guanghua,Li, Yajuan,Allen, Jeffrey,Zhong, Rui,Chen, Beibei,Kim, Minsoo,Wang, Tao,Heiser, Laura M,Realubit Nature Publishing Group, a division of Macmillan P 2014 Nature biotechnology Vol.32 No.12
Recent therapeutic successes have renewed interest in drug combinations, but experimental screening approaches are costly and often identify only small numbers of synergistic combinations. The DREAM consortium launched an open challenge to foster the development of in silico methods to computationally rank 91 compound pairs, from the most synergistic to the most antagonistic, based on gene-expression profiles of human B cells treated with individual compounds at multiple time points and concentrations. Using scoring metrics based on experimental dose-response curves, we assessed 32 methods (31 community-generated approaches and SynGen), four of which performed significantly better than random guessing. We highlight similarities between the methods. Although the accuracy of predictions was not optimal, we find that computational prediction of compound-pair activity is possible, and that community challenges can be useful to advance the field of in silico compound-synergy prediction.
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