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RISS 인기검색어
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- 저자 : Aliakbar Seyfkordi (검색결과 2 건)
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Efficacy Comparison of Nanoniosomal and Pegylated Nanoniosomal Cisplatin on A172 Cell Line
Mahrokh Babaei,Mehdi Ardjmand,Azim Akbarzadeh,Aliakbar Seyfkordi 한국조직공학과 재생의학회 2014 조직공학과 재생의학 Vol.11 No.5
In this study, Cisplatin was loaded into nanoniosom and pegylated nanoniosom employing reverse phase evaporation method. Span 60, cholesterol and Cisplatin were combined together at certain concentrations in this method. This study reports the efficacy of nanoniosome Cisplatin and pegylated nanoniosome Cisplatin on brain cancer (A172) cell line. All of the results are presented from three independent tests. The obtained results showed that the stability of prepared formulation was increased by pegylation. Encapsulation efficiency and loading efficiency of Cisplatin in pegylated and non-pegylated niosomal formulations were estimated 48.2±2.05%, 43.6±4.59%, 4.38±0.28%, 4.36±0.08%, respectively. The average diameters of pegylated and non-pegylated nanoparticles of niosomes were determined by Zeta sizer which was 205.5±4.60 nm and 242.1±5.10 nm, respectively. The release of drug was studied by dialysis method. The amounts of drug released from pegylated and non-pegylatednanoniosomes were calculated 82.73±1.36% and 97.53±0.55% during 48 hr, respectively. The toxicity of formulated Cisplatin was studied by MTT assay and the results revealed that the cytotoxicity effect of pegylated nanoniosomal Cisplatin was more than nanoniosomal Cisplatin. The IC50 for nanoniosomal Cisplatin was estimated 123.2±0.98 μg/mL while IC50 for pegylated nanoniosomal formulation was calculated 79.8±1.14 μg/mL.
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Prediction of biodiesel properties and its characterization using fatty acid profiles
Mehdi Ardjmand,Mahdieh Samavi,Barat Ghobadian,Aliakbar Seyfkordi 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.7
Biodiesel, the mono-alkyl esters of vegetable oils or animal fats, is an eco-friendly alternative to petrodiesel. The molecular structures of biodiesels, fatty acid methyl esters were applied to predict the characteristics of biodiesel fuels. Based on the structural similarity of biodiesel and petroleum fractions, molecular weight of biodiesel was correlated with other characteristics including boiling point, viscosity and specific-gravity in the form of three equations. For 24 different kinds of biodiesel, the minimum average relative deviation (ARD) of these correlations was calculated to be 0.68%. Moreover, two correlations were developed to predict viscosity and flash point of biodiesel as a function of weighted-average number of carbon atoms (NC) and weighted-average number of double bonds (NDB) with ARD 3.72% and 4.24% respectively. Also, a high degree of correlation was shown by the logarithmic function with ARD 0.30% between specific gravity and viscosity of biodiesel. Proposed predictive models were verified by experimental data.
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