CONCEPT AND MANAGEMENT OF ISTISQĀ' (OEDEMA) IN UNANI SYSTEM OF MEDICINE

Khan, Khalid Ali,Zakir, Mohammad,Khan, Shahid Ali,Khan, Rashid Ali Cellmed Orthocellular Medicine and Pharmaceutical 2021 셀메드 (CellMed) Vol.11 No.1

Ascites is the accumulation of fluid in the peritoneal cavity, and it is generally allied with liver disease like cirrhosis of the liver. The ascites is commonly associated with liver cirrhosis, malignancy, or cardiovascular disease today. The liver cirrhosis is the most significant cause of ascites in developed countries as per the available data. In the modern medicine system, the treatment includes the restriction of sodium intake, use of diuretics, and paracentesis done in severe cases. There are many side effects of synthetic chemical diuretics, and their long-term use is not recommended. The alternative medicine like Unani system of medicine provides natural diuretics and drugs which also have protective effects on kidney, liver and other internal organs. It is well known in all drug systems that the prognosis is poor in ascites, but the use of Unani herbal medicines can minimize the side effects caused by synthetic chemical diuretics. The natural herbs used for the management of ascites have fewer side effects as compared to synthetic drugs. The natural drugs can be used for longer duration and provide some dietary supplement which improves the quality of life. This review addressed the thorough treatment of ascites by natural diet and medications.

MANAGEMENT OF HASĀH WA RAML AL-KULYA (NEPHROLITHIASIS) IN UNANI SYSTEM OF MEDICINE: A REVIEW

Khan, Khalid Ali,Khan, Rashid Ali,Zakir, Mohammad Cellmed Orthocellular Medicine and Pharmaceutical 2020 셀메드 (CellMed) Vol.10 No.3

The kidneys are exposed to toxicants and waste product and can be affected easily by these toxicants and by products of the metabolism. The consumption of adequate water is necessary to remove waste and to keep kidney healthy. Deficiency of liquid in the blood leads to various adverse effects on the kidney. The most common adverse deficiency of liquid in blood is deposition of solid matter in the kidney and subsequently formation of kidney stone. Nephrolithiasis (kidney stone) can be treated by drugs if it is small in size but if it blocks the route due to its big size then surgery is the only way to remove it. The recurrence rate of the problem is very high and it may reappear within 10 years. In Unani literature Hasāh wa Raml al-Kulya (nephrolithiasis) is described in detail. As per Unani literature stagnation of Ghalīz mādda (filthy and viscous matter) in the kidney is the main cause of the formation of kidney stone. Various single and compound formulations drugs are described for the management of kidney stone which are very effective as well as safe. Management is divided into two parts i.e. symptomatic treatment to relieve pain and to methods adopted to remove stone from the kidney. Musakkin-i-Waja'(analgesic) drugs are used for pain while Mufattit-i-Hasāh (lithotriptic) and Mudirr-i-Bawl (Diuretic) drugs are used to remove stone. Majoon Aqrab, Qurs Kaknaj and Dawa-e-Gurda etc. are compound drugs mentioned in literature for removal of kidney stone. Single drugs like Alu Balu, Tukhm Khayar, and Kharkhask etc. are also used for same purpose.

Dual-Buck AC–AC Converter With Inverting and Non-Inverting Operations

Khan, Usman Ali,Khan, Ashraf Ali,Cha, Honnyong,Kim, Heung-Geun,Kim, Juyong,Baek, Ju-Won Institute of Electrical and Electronics Engineers 2018 IEEE transactions on power electronics Vol.33 No.11

<P>In this paper, a novel buck–boost ac–ac converter is proposed. The basic switching unit of the proposed converter is a unidirectional buck circuit; therefore, it has no shoot-through worries. It can achieve safe commutation without using <I>RC</I> snubbers or soft commutation strategies. It can be implemented with power MOSFETs without their body diodes conducting and, for current freewheeling external diodes, can be used to minimize the reverse recovery issues and related loss. It has a bipolar voltage gain with both inverting and non-inverting operations. The non-inverting operation can be used to compensate voltage sag, and inverting operation can be used to compensate voltage swell. Therefore, the proposed converter as a dynamic voltage restorer is capable of compensating for both voltage sag and swell in a wide range. The detailed theoretical analysis followed by detailed experimental results of a 300-W prototype converter is provided.</P>

Aberrant Promoter Methylation at CpG Cytosines Induce the Upregulation of the E2F5 Gene in Breast Cancer

Arshad Ali,Farman Ullah,Irum Sabir Ali,Ahmad Faraz,Mumtaz Khan,Syed Tahir Ali Shah,Nawab Ali,Muhammad Saeed 한국유방암학회 2016 Journal of breast cancer Vol.19 No.2

Purpose: The promoter methylation status of cell cycle regulatory genes plays a crucial role in the regulation of the eukaryotic cell cycle. CpG cytosines are actively subjected to methylation during tumorigenesis, resulting in gain/loss of function. E2F5 gene has growth repressive activities; various studies suggest its involvement in tumorigenesis. This study aims to investigate the epigenetic regulation of E2F5 in breast cancer to better understand tumor biology. Methods: The promoter methylation status of 50 breast tumor tissues and adjacent normal control tissues was analyzed. mRNA expression was determined using SYBR® green quantitative polymerase chain reaction (PCR), and methylation- specific PCR was performed for bisulfite-modified genomic DNA using E2F5-specific primers to assess promoter methylation. Data was statistically analyzed. Results: Significant (p<0.001) upregulation was observed in E2F5 expression among tumor tissues, relative to the control group. These samples were hypo-methylated at the E2F5 promoter region in the tumor tissues, compared to the control. Change in the methylation status (Δmeth) was significantly lower (p=0.022) in the tumor samples, indicating possible involvement in tumorigenesis. Patients at the postmenopausal stage showed higher methylation (75%) than those at the premenopausal stage (23.1%). Interestingly, methylation levels gradually increased from the early to the advanced stages of the disease (p<0.001), which suggests a putative role of E2F5 methylation in disease progression that can significantly modulate tumor biology at more advanced stage and at postmenopausal age (Pearson’s r=0.99 and 0.86, respectively). Among tissues with different histological status, methylation frequency was higher in invasive lobular carcinoma (80.0%), followed by invasive ductal carcinoma (46.7%) and ductal carcinoma in situ (20.0%). Conclusion: Methylation is an important epigenetic factor that might be involved in the upregulation of E2F5 gene in tumor tissues, which can be used as a prognostic marker for breast cancer.

Toxic potential of some indigenous plant oils against the rice weevil, Sitophilus oryzae (Linnaeus)

Hafiz Azhar Ali KHAN,Waseem AKRAM,이수미,Taskeen AHMAD,Kamran MAQSOOD,Hassan Ali KHAN,Muhammad Waqas NAZIR,Muhammad Faisal JAVAID 한국곤충학회 2019 Entomological Research Vol.49 No.3

The present study was conducted to evaluate the toxic potential of five indigenous plant oils: black pepper (Piper nigrum), Chinese cinnamon (Cinnamomum cassia), garlic (Allium sativum), river red gum (Eucalyptus camaldulensis), and yellow oleander (Thevetia peruviana), against laboratory reared Sitophilus oryzae adults. The bioassays were done by the diet incorporation method with concentrations ranging from 50 ppm to 500 ppm. Based on lethal concentrations to kill 50% (LC50) of the subjected weevils, T. peruviana proved to be the most toxic having the lowest LC50 values, 414.58, 201.94, and 129.52 ppm, after 7, 14, and 21 days of exposure, respectively, followed by E. camaldulensis (475.51, 366.65, and 251.28 ppm, respectively). The rest of the plant oils also showed toxic potential, but these were less toxic compared with T. peruviana and E. camaldulensis. With respect to the time taken to cause 50% mortality (LT50) of the exposed weevils, T. peruviana had LT50 at 14.54 days followed by P. nigrum (22.09 days), E. camaldulensis (24.29 days), and C. cassia (28.71 days). Whereas, A. sativum took the longest time (44.47 days) to cause 50% mortality of the exposed weevils. In conclusion, the result revealed toxic potential of tested plant oils, and suggests further studies under simulated-field conditions should be included in the management plan for S. oryzae.

Investigation on the effect of alkyl chain linked mono-thioureas as Jack bean urease inhibitors, SAR, pharmacokinetics ADMET parameters and molecular docking studies

Larik, Fayaz Ali,Faisal, Muhammad,Saeed, Aamer,Channar, Pervaiz Ali,Korabecny, Jan,Jabeen, Farukh,Mahar, Ihsan Ali,Kazi, Mehar Ali,Abbas, Qamar,Murtaza, Ghulam,Khan, Gul Shahzada,Hassan, Mubashir,Seo, Academic Press 2019 Bioorganic chemistry Vol.86 No.-

<P><B>Abstract</B></P> <P>The increasing resistance of pathogens to common antibiotics, as well as the need to control urease activity to improve the yield of soil nitrogen fertilization in agricultural applications, has stimulated the development of novel classes of molecules that target urease as an enzyme. In this context, the newly developed compounds on the basis of 1-heptanoyl-3-arylthiourea family were evaluated for Jack bean urease enzyme inhibition activity to validate their role as potent inhibitors of this enzyme. 1-Heptanoyl-3-arylthioureas were obtained in excellent yield and characterized through spectral and elemental analysis. All the compounds displayed remarkable potency against urease inhibition as compared to thiourea standard. It was found that novel compounds fulfill the criteria of drug-likeness by obeying Lipinski’s rule of five. Particularly compound <B>4a</B> and <B>4c</B> can serve as lead molecules in 4D (drug designing discovery and development). Kinetic mechanism and molecular docking studies also carried out to delineate the mode of inhibition and binding affinity of the molecules.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A new family of 1-heptanoyl-3-arylthioureas (<B>4a-4j</B>) was synthesized in excellent yield. </LI> <LI> The synthesized 1-heptanoyl-3-arylthiourea family were evaluated for Jack bean urease enzyme inhibition activity. </LI> <LI> Particularly compound <B>4a</B> and <B>4c</B> can serve as lead molecules in 4D (drug designing discovery and development). </LI> <LI> Kinetic mechanism and molecular docking studies also carried out to delineate the mode of inhibition and binding affinity. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

HIGHER ORDER NONLOCAL NONLINEAR BOUNDARY VALUE PROBLEMS FOR FRACTIONAL DIFFERENTIAL EQUATIONS

Khan, Rahmat Ali Korean Mathematical Society 2014 대한수학회보 Vol.51 No.2

In this paper, we study the method of upper and lower solutions and develop the generalized quasilinearization technique for the existence and approximation of solutions to some three-point nonlocal boundary value problems associated with higher order fractional differential equations of the type $$^c{\mathcal{D}}^q_{0+}u(t)+f(t,u(t))=0,\;t{\in}(0,1)$$ $$u^{\prime}(0)={\gamma}u^{\prime}({\eta}),\;u^{\prime\prime}(0)=0,\;u^{\prime\prime\prime}(0)=0,{\ldots},u^{(n-1)}(0)=0,\;u(1)={\delta}u({\eta})$$, where, n-1 < q < n, $n({\geq}3){\in}\mathbb{N}$, 0 < ${\eta},{\gamma},{\delta}$ < 1 and $^c\mathcal{D}^q_{0+}$ is the Caputo fractional derivative of order q. The nonlinear function f is assumed to be continuous.

Object-oriented and ontology-alignment patterns-based expressive Mediation Bridge Ontology (MBO)

Khan, Wajahat Ali,Amin, Muhammad Bilal,Khattak, Asad Masood,Hussain, Maqbool,Afzal, Muhammad,Lee, Sungyoung,Kim, Eun Soo SAGE Publications 2015 JOURNAL OF INFORMATION SCIENCE Vol.41 No.3

<P>The Semantic Web is dependent on extensive knowledge management by interlinking resources on the web using matching techniques. This role is played by the progressing domain of ontology matching, by introducing ontology-matching tools. The focus of these matching tools is limited to matching techniques and automation, rather than expressive formal representation of alignments. We propose Mediation Bridge Ontology (MBO), an expressive alignment representation ontology used to store correspondences between matching ontologies matched by our ontology-matching tool, System for Parallel Heterogeneity Resolution (SPHeRe). The MBO utilizes object-oriented design patterns and the proposed ontology-alignment design patterns to provide extendibility and reusability factors to SPHeRe system. We compared our proposed system with existing systems using Coupling Factor, Number of Polymorphic methods and Rate of Change metrics to support extendibility and reusability. These factors contribute to the overall objective of interoperability for knowledge management in the Semantic Web.</P>

Analysis of Driving Stability and Vibration of a 20-kW Self-Propelled 1-Row Chinese Cabbage Harvester

ALI MOHAMMOD,이예슬,Chowdhury Milon,KHAN NADEEM ALI,Swe Khine Myat,Rasool Kamal,Kabir Md Shaha Nur,이대현,정선옥 한국농업기계학회 2021 바이오시스템공학 Vol.46 No.1

Purpose Overturning and high vibration levels are major causes of agricultural farm fatalities and mechanical troubles during operation. This study assessed the stability angles of a self-propelled 1-row Chinese cabbage harvester and measured the vibration levels for safety under different conditions. Methods The stability of the Chinese cabbage harvester was investigated using computational methods, and the vibration levels were measured on off-road and field conditions. The three-dimensional model of the Chinese cabbage harvester was designed and simulated to evaluate the static stability angles employing commercial software. The relationship between vehicle and deformable soil was calculated using the empirical models. The critical angles and the climbing ability of the developed harvester were examined under loaded and unloaded conditions. The vibration exposures were measured on the cabbage conveyor and the power transmission part in static, off-road, and field operation conditions under various speeds and slopes. Results The stability simulation results showed the minimum lateral stability angles of the harvester were pointed on the loaded condition compared to the unloaded condition. The maximum sideways overturning angle of the Chinese cabbage harvester was recorded as 32° at 150° ground angle and 30° at 270° ground angle, from the moving directions clockwise, for unloaded and loaded conditions. The high levels of vibration were measured at 0.19, 1.64, and 1.38 m/s2 for static, off-road, and field conditions at high speeds among X-, Y-, and Z-axis directions, respectively. Besides, the considerable vector sum (Av) exposures were calculated 1.54, 2.14, and 2.48 m/s2 at 0.3, 0.6, and 0.9 m/s forward speeds on the cabbage conveyor part. Conclusion The concept and guidelines of this research could help to protect operators from safety risks and expose vibration characteristics during farm operations of the self-propelled Chinese cabbage harvester prototype.

TRANS-SEPARABILITY IN THE STRICT AND COMPACT-OPEN TOPOLOGIES

Khan, Liaqat Ali Korean Mathematical Society 2008 대한수학회보 Vol.45 No.4

We give a characterization of trans-separability for the function spaces ($C_b(X,\;E)$, $\beta$), (C(X, E), k) and ($C_b(X,\;E)$, u) in the case of E any general topological vector space.