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- 저자 : Alejandro Várez (검색결과 2 건)
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Frequency spectra characterization of noncoding human genomic sequences
O. Paredes,Rebeca Romo‑Vázquez,Israel Román‑Godínez,Hugo Vélez‑Pérez,Ricardo A. Salido‑Ruiz,J. Alejandro Morales 한국유전학회 2020 Genes & Genomics Vol.42 No.10
Background Noncoding sequences have been demonstrated to possess regulatory functions. Its classifcation is challenging because they do not show well-defned nucleotide patterns that can correlate with their biological functions. Genomic signal processing techniques like Fourier transform have been employed to characterize coding and noncoding sequences. This transformation in a systematic whole-genome noncoding library, such as the ENCODE database, can provide evidence of a periodic behaviour in the noncoding sequences that correlates with their regulatory functions. Objective The objective of this study was to classify diferent noncoding regulatory regions through their frequency spectra. Methods We computed machine learning algorithms to classify the noncoding regulatory sequences frequency spectra. Results The sequences from diferent regulatory regions, cell lines, and chromosomes possessed distinct frequency spectra, and that machine learning classifers (such as those of the support vector machine type) could successfully discriminate among regulatory regions, thus correlating the frequency spectra with their biological functions Conclusion Our work supports the idea that there are patterns in the noncoding sequences of the genome.
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Sydonne Swaby,Nieves Ureña,María Teresa Pérez-Prior,Carmen del Río,Alejandro Várez,Jean-Yves Sanchez,Cristina Iojoiu,Cristina Iojoiu,Belén Levenfeld 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.122 No.-
A series of proton exchange membranes based on sulfonated multiblock copolymers with three polysulfone(PSU) and polyphenylsulfone (PPSU) ratios (50/50, 60/40 and 75/25) are prepared following a synthesisstrategy that aims to achieve a microphase separation. A selective sulfonation of PSU blocks wasobserved in copolymers with a high proportion of PSU. The water uptake is higher in these materials(31% and 57% for SPES 50/50 and SPES 75/25, respectively at 60 C) while the tensile strength was lower(56.0 MPa and 40.6 MPa for SPES 50/50 and SPES 75/25 in the H+ form, respectively). Ionic conductivity ofSPES 75/25 membranes measured both ex situ and in situ at 80 C is 25 and 31 mScm1, respectively. Fuelcell tests reveal that SPES 75/25 shows the highest value for the maximum power density (670 mWcm2at 70 C and 100% of RH) which is higher than that achieved for SPES 50/50 (400 mWcm2). In addition,the high current density obtained for SPES 75/25 (1000 mAcm2 at 0.6 V and 70 C) compared withSPES50/50 (600 mAcm2) and Nafion 112 (450 mAcm2 at 75 C) shows its promising properties as solidelectrolyte in polymeric fuel cells.
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