Larvicidal activity of leaf extract of Nerium oleander L. and its synthesized metallic nanomaterials on dengue vector, Aedes aegypti

Al‐Hakimi Ahmed N.,Abdulghani Mahfoudh A.M.,Alhag Sadeq K.,Aroua Lotfi M.,Mahyoub Jazem A. 한국곤충학회 2022 Entomological Research Vol.52 No.3

The development of natural insecticide from plant products may have a beneficial effect as a promising candidate for practical strategies for controlling vector-borne diseases without current treatment. The present study was carried out to characterize green synthesized metallic nanomaterials for silver (Ag-NPs) and gold (Au-NPs) from extract leaf of Nerium oleander L., assess in vivo toxicity, and evaluate the larvicidal activity against Aedes aegypti. The prepared nanomaterials (Ag-NPs and Au-NPs) were characterized by Ultraviolet–Visible Spectroscopy (UV–Vi s ) , F o u r i e r transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and transmission electron microscopy (TEM). In addition, the subacute in vivo toxicity method was used to assess the extract and the nanomaterials (Ag-NPs and Au-NPs); in evaluating larvicidal activities using the World Health Organization (WHO) method. The Ag-NPs and Au-NPs were confirmed by shifting the absorption band in UV–Vi s , FTIR spectrums toward higher wavelengths. TEM and XRD analysis were revealed that the average particle size of Au-NPs and Ag-NPs showed 15.30 and 11.48 nm, respectively. In the toxicity experiment, no mortality or signs of toxicity were reported in all groups of treated animals; in larvicidal activity, the Au-NPs and Ag-NPs with LC50 36.0716 and 46.645 ppm respectively showed more effectiveness than leaf extract alone 108.1665 ppm. Collectively, extract leaf of N. oleander L. can be efficiently used to synthesize metallic nanomaterials with silver and gold, which can be adopted as a natural source of insecticide against Ae. aegypti.

Synthesis, Spectroscopic, and Biological Studies of Chromium(III), Manganese(II), Iron(III), Cobalt(II), Nickel(II), Copper(II), Ruthenium(III), and Zirconyl(II) Complexes of N¹,N²-Bis(3-((3-hydroxynaphthalen-2-yl)methylene-amino)pr

Al-Hakimi, Ahmed N.,Shakdofa, Mohamad M.E.,El-Seidy, Ahemd M.A.,El-Tabl, Abdou S. Korean Chemical Society 2011 대한화학회지 Vol.55 No.3

[ $N^1,N^2$ ]bis(3-((3-hydroxynaphthalen-2-yl)methylene-amino)propyl)phthalamide ($H_4L$, 1) 의 새로운 크롬(III), 망간(II), 철(III), 코발트(II), 니켈(II), 구리(II), 루테늄(III) 및 산화 지르코늄(II) 착물을 합성하여 원소분석, 물리적 성질 및 분광학적으로 특성을 규명하였다. 분광학적 결과를 통해 이 리간드는 $[H_4LMX_2(H_2O)]{\cdot}nH_2O$ (M = Cu(II), Ni(II), Co(II), X = Cl 또는 $NO_3$)의 일반식을 갖는 착물2-5에서는 중성의 삼배위 리간드로 행동한다. 또는 $[H_4L(ZrO)_2Cl_2]{\cdot}8H_2O$ 의 일반식을 갖는 착물 6-9 에서는 이염기성 육배위 리간드로 행동한다. DMF 용액에서의 몰전기전도도 실험결과 이들 착물은 비이온성을 나타낸다. 고체 구리착물 2, 5 및 6 의 ESR 스펙트럼에서 $g_{\parallel}$ >g> $g_e$을 보이는데, 이는 일그러진 팔면체구조와 큰 공유결합성을 갖는 $d{_x}^2{_{-y}}^2$ 오비탈에 비공유 전자쌍이 존재함을 의미한다. 이합체 구리(II) 착물 $[H_2LCu_2Cl_2(H_2O)_4]{\cdot}3H_2O$ (6)에 대해 두 구리원자 사이의 거리를 ESR 스펙트럼으로부터 추정한 parallel component 의 field zero splitting 파라메타를 이용하여 계산하였다. 이들 화합물의 항박테리아 및 항균 활성도를 측정한 결과, 몇가지 금속 착물의 경우 표준시약인 tetracycline (박테리아) 및 Amphotricene B (균류)보다 더 큰 저해효과를 보였다. Novel chromium(III), manganese(II), iron(III), cobalt(II), nickel(II), copper(II), ruthenium(III), and zirconyl(II) complexes of $N^1,N^2$-bis(3-((3-hydroxynaphthalen-2-yl)methylene-amino)propyl)phthalamide ($H_4L$, 1) have been synthesized and characterized by elemental, physical, and spectral analyses. The spectral data showed that the ligand behaves as either neutral tridentate ligand as in complexes 2-5 with the general formula $[H_4LMX_2(H_2O)]{\cdot}nH_2O$ (M=Cu(II), Ni(II), Co(II), X = Cl or $NO_3$), neutral hexadentate ligand as in complexes 10-12 with the general formula $[H_4LM_2Cl_6]{\cdot}nH_2O$ (M=Fe(III), Cr(III) or Ru(III)), or dibasic hexadentate ligand as in complexes 6-9 with the general formula $[H_2LM_2Cl_2(H_2O)_4]{\cdot}nH_2O$ (M = Cu(II), Ni(II), Co(II) or Mn(II), and 13 with general formula $[H_4L(ZrO)_2Cl_2]{\cdot}8H_2O$. Molar conductance in DMF solution indicated the non-ionic nature of the complexes. The ESR spectra of solid copper(II) complexes 2, 5, and 6 showed $g_{\parallel}$ >g> $g_e$, indicating distorted octahedral structure and the presence of the unpaired electron in the $N^1,N^2$ orbital with significant covalent bond character. For the dimeric copper(II) complex $[H_2LCu_2Cl_2(H_2O)_4]{\cdot}3H_2O$ (6), the distance between the two copper centers was calculated using field zero splitting parameter for the parallel component that was estimated from the ESR spectrum. The antibacterial and antifungal activities of the compounds showed that, some of metal complexes exhibited a greater inhibitory effect than standard drug as tetracycline (bacteria) and Amphotricene B (fungi).

Synthesis, Characterization and Biological Studies of New Mn(II), Ni(II), Co(II), Cu(II) and Zn(II) of 2-(benzothiazol-2-yl)-N'-(2,5-dihydroxybenzylidene)acetohydrazide

Abdou S. El-Tabl,Mohamad M. E. Shakdofa,Ahmed N. Al-Hakimi,Ahmed M. A. El-Seidy 대한화학회 2011 대한화학회지 Vol.55 No.1

New series of Mn(II), Ni(II), Co(II), Cu(II) and Zn(II) of the 2-(benzothiazol-2-yl)-N'-(2,5-dihydroxybenzylidene)acetohydrazide have been synthesized and characterized by elemental analysis, IR, UV-vis, ^1H-NMR, mass and ESR spectra, magnetic susceptibility and molar conductivity measurements. The spectral data and magnetic measurements of the complexes indicate that, the geometries are either square planar or octahedral. The biological activity of the ligand and its complexes against fungi (Aspergillus nigar and Fusarium oxysporium) were investigated. The metal complexes exhibited higher activity than both the parent ligand and the corresponding metal ion.

Synthesis, Characterization and Antimicrobial Activities of Hydrazone Ligands Derived from 2-(phenylamino)acetohydrazide and Their Metal Complexes

EL-Saied, F.A.,Shakdofa, M.M.E.,Al-Hakimi, A.N. Korean Chemical Society 2011 대한화학회지 Vol.55 No.3

N'-(2-hydroxybenzyl)-2-(phenylamino)acetohydrazide ($H_2L^1$, 1) 및 N'-((3-hydroxy-naphthalen-2-yl)methylene)-2-(phenylamino)acetohydrazide ($H_2L^2$, 13)에 대한 VO(II), ZrO(II), Hf(IV), $UO_2$(II), Sn(II), V(V)$O_3$, Ru(III), Cd(II), Ho(III) 및 Yb(III) 착물을 합성하여 원소분석, $^1H$ NMR, IR, UV-Vis, 전기전도도 및 열분석 (DTA 및 TG)을 통해 특성을 조사하였다. 이들 리간드는 분광학적 결과에 의하면 중성 이배위, 일염기성 이배위, 일열기성 삼배위 또는 이염기성 삼배위 리간드로 행동한다. 그 결과 azomethine 질소원자, 양성자화 되어있거나 또는 탈양성자화 된 형태의 페놀 하이드록시 그룹 그리고 에놀 또는 케톤형 카드보닐 그룹을 통해 금속이온에 결합한다. 이들 리간드와 그 금속 착물들은 모체 리간드 및 금속이온 용액에 비해 높은 항균 및 항박테리아 저해효과를 보인다. 대부분의 금속 착물은 표준 항균성 시약 (amphotricene B) 보다 더 높은 항균 활동성을 보인다. 또한 이들 리간드와 착물은 항박테리아 활성도보다는 항균활성도에서 더 높은 수치를 보인다. VO(II), ZrO(II), Hf(IV), $UO_2$(II), Sn(II), V(V)$O_3$, Ru(III), Cd(II), Ho(III) and Yb(III) complexes of N'-(2-hydroxybenzyl)-2-(phenylamino)acetohydrazide ($H_2L^1$, 1) and N'-((3-hydroxy-naphthalen-2-yl)methylene)-2-(phenylamino)-acetohydrazide ($H_2L^2$, 13) have been synthesized and characterized by elemental analyses, $^1H$ NMR, IR, UV-Vis, conductance, thermal analyses (DTA and TG). The spectral data showed that the ligands behave as neutral bidentate, monobasic bidentate, monobasic tridentate or bibasic tridentate ligand bonded to the metal ions through the azomethine nitrogen atoms, phenolic hydroxyl group in protonated or deprotonated form and enolic or ketonic carbonyl group. The ligands and their metal complexes exhibit higher antifungal and antibacterial inhibitory effects than parent ligands and the solution of metal ions. Most of metal complexes exhibit higher antifungal activity than standard antifungal drug (amphotricene B). It is also clear that the ligands and their metal complexes have higher antifungal activity than antibacterial activity.

Synthesis, Characterization and Biological Studies of New Mn(II), Ni(II), Co(II), Cu(II) and Zn(II) of 2-(benzothiazol-2-yl)-N'-(2,5-dihydroxybenzylidene)acetohydrazide

El-Tabl, Abdou S.,Shakdofa, Mohamad M.E.,El-Seidy, Ahmed M.A.,Al-Hakimi, Ahmed N. Korean Chemical Society 2011 대한화학회지 Vol.55 No.1

2-(Benzothiazol-2-yl)-N'-(2,5-dihydroxybenzylidene)acetohydrazide 에대한새로운일련의 Mn(II), Ni(II), Co(II), Cu(II) 및 Zn(II) 착물을 합성하여 그 특성을 원소분석, IR, UV-vis, $^1H$-NMR, 질량분석, ESR, 자기수자율 및 몰 전기전도도 측정에 의하여 조사하였다. 이들 착물의 기하구조가 사각평면 또는 팔면체임을 분광학적 데이터 및 자기적 측정으로부터 알았다. 이 리간드와 해당착물의 세균에(Aspergillus nigar 및 Fusarium oxysporium) 대한생물학적활성을 조사하였다. 그 결과, 금속착물들은 리간드 및 금속이온 모두에 비해 더 큰 활성을 나타내었다. New series of Mn(II), Ni(II), Co(II), Cu(II) and Zn(II) of the 2-(benzothiazol-2-yl)-N'-(2,5-dihydroxybenzylidene) acetohydrazide have been synthesized and characterized by elemental analysis, IR, UV-vis, $^1H$-NMR, mass and ESR spectra, magnetic susceptibility and molar conductivity measurements. The spectral data and magnetic measurements of the complexes indicate that, the geometries are either square planar or octahedral. The biological activity of the ligand and its complexes against fungi (Aspergillus nigar and Fusarium oxysporium) were investigated. The metal complexes exhibited higher activity than both the parent ligand and the corresponding metal ion.