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Chaetoglobosin A, an Inhibitor of Bleb Formation on K562 Cells Induced by Phorbol 12,13-Dibutyrate
KO, HACK-RYONG,KIM, BO YEON,AHN, SOON-CHEOL,OH, WON KEUN,KIM, JIN-HEE,LEE, HYUN SUN,KIM, HWAN-MOOK,HAN, SANG-BAE,MHEEN, TAE0ICK,AHN, JONG-SEOG 한국미생물 · 생명공학회 1998 Journal of microbiology and biotechnology Vol.8 No.6
Ahn, Yong-Yoon,Yun, Eun-Tae,Seo, Ji-Won,Lee, Changha,Kim, Sang Hoon,Kim, Jae-Hong,Lee, Jaesang American Chemical Society 2016 Environmental science & technology Vol.50 No.18
<P>This study demonstrates the capability of noble metal nanoparticles immobilized on Al2O3 or TiO2 support to effectively activate peroxymonosulfate (PMS) and degrade select organic compounds in water. The noble metals outperformed a benchmark PMS activator such as Co2+ (water-soluble) for PMS activation and organic compound degradation at acidic pH and showed the comparable activation capacity at neutral pH. The efficiency was found to depend on the type of noble metal (following the order of Pd > Pt approximate to Au >> Ag), the amount of noble metal deposited onto the support, solution pH, and the type of target organic substrate. In contrast to common PMS-activated oxidation processes that involve sulfate radical as a main oxidant, the organic compound degradation kinetics were not affected by sulfate radical scavengers and exhibited substrate dependency that resembled the PMS activated by carbon nanotubes. The results presented herein suggest that noble metals can mediate electron transfer from organic compounds to PMS to achieve persulfate-driven oxidation, rather than through reductive conversion of PMS to reactive sulfate radical.</P>
AHN, JI HYEON,CHEN, BAI HUI,SHIN, BICH-NA,LEE, TAE-KYEONG,CHO, JEONG HWI,KIM, IN HYE,PARK, JOON HA,LEE, JAE-CHUL,TAE, HYUN-JIN,LEE, CHOONG-HYUN,WON, MOO-HO,LEE, YUN LYUL,CHOI, SOO YOUNG,HONG, SEONGKWE D.A. Spandidos 2016 MOLECULAR MEDICINE REPORTS Vol. No.
<P>Catalase (CAT) is an important antioxidant enzyme and is crucial in modulating synaptic plasticity in the brain. In this study, CAT expression as well as neuronal distribution was compared in the hippocampus among young, adult and aged mice and rats. Male ICR mice and Sprague Dawley rats were used at postnatal month (PM) 1, PM 6 and PM 24 as the young, adult and aged groups, respectively (n=14/group). CAT expression was examined by immunohistochemistry and western blot analysis. In addition, neuronal distribution was examined by NeuN immunohistochemistry. In the present study, the mean number of NeuN-immunoreactive neurons was marginally decreased in mouse and rat hippocampi during aging, although this change was not identified to be significantly different. However, CAT immunoreactivity was significantly increased in pyramidal and granule neurons in the adult mouse and rat hippocampi and was significantly decreased in the aged mouse and rat hippocampi compared with that in the young animals. CAT protein levels in the hippocampus were also lowest in the aged mouse and rat hippocampus. These results indicate that CAT expression is significantly decreased in the hippocampi of aged animals and decreased CAT expression may be closely associated with aging.</P>
Diagnostic Role of Bile Pigment Components in Biliary Tract Cancer
Ahn Keun Soo,Kang Koo Jeong,Kim Yong Hoon,Kim Tae-Seok,Cho Kwang Bum,Kim Hye Soon,Baek Won-Ki,Suh Seong-Il,Han Jin-Yi 한국응용약물학회 2023 Biomolecules & Therapeutics(구 응용약물학회지) Vol.31 No.6
Bile pigment, bilirubin, and biliverdin concentrations may change as a results of biliary tract cancer (BTC) altering the mechanisms of radical oxidation and heme breakdown. We explored whether changes in bile pigment components could help distinguish BTC from benign biliary illness by evaluating alterations in patients with BTC. We collected bile fluid from 15 patients with a common bile duct stone (CBD group) and 63 individuals with BTC (BTC group). We examined the bile fluid’s bilirubin, biliverdin reductase (BVR), heme oxygenase (HO-1), and bacterial taxonomic abundance. Serum bilirubin levels had no impact on the amounts of bile HO-1, BVR, or bilirubin. In comparison to the control group, the BTC group had considerably higher amounts of HO-1, BVR, and bilirubin in the bile. The areas under the curve for the receiver operating characteristic curve analyses of the BVR and HO-1 were 0.832 (p<0.001) and 0.891 (p<0.001), respectively. Firmicutes was the most prevalent phylum in both CBD and BTC, according to a taxonomic abundance analysis, however the Firmicutes/Bacteroidetes ratio was substantially greater in the BTC group than in the CBD group. The findings of this study showed that, regardless of the existence of obstructive jaundice, biliary carcinogenesis impacts heme degradation and bile pigmentation, and that the bile pigment components HO-1, BVR, and bilirubin in bile fluid have a diagnostic significance in BTC. In tissue biopsies for the diagnosis of BTC, particularly for distinguishing BTC from benign biliary strictures, bile pigment components can be used as additional biomarkers.
Ahn, Kwang-Il,Jung, YongHun,Shin, Jae-Uk,Kim, Won-Tae Elsevier 2018 Annals of nuclear energy Vol.113 No.-
<P><B>Abstract</B></P> <P>The Fukushima accident on March 11, 2011 has shown the relevance of examinations of severe accident inside a spent fuel pool (SFP) during beyond-design-basis external events, and the necessity for provisions to cope effectively with such events through a relevant severe accident management (SAM) strategy. Although the low decay heat of fuel assemblies and the considerable water inventory in an SFP can slow the progress of an accident compared to an accident in the reactor core, the numerous number of fuel assemblies stored inside it and the fact that the SFP building is not leak-tight present the potential for the formation of a direct path for fission products to rise from the SFP into the environment (i.e., a much greater severe accident risk). The purpose of this paper is to assess the effectiveness and success conditions of an emergency makeup water injection strategy, which is being as a representative SFP SAM measure after the Fukushima accident. Two typical accident scenarios (loss-of-cooling and loss-of-pool-inventory accidents) and two different reactor operating modes (normal and refueling modes) were considered in the analysis. For the foregoing SAM strategies, the analysis results and relevant insights are summarized in relation to two major aspects: (a) the key events of the progression of an accident (such as the exposure, heat-up and degradation of the fuel assemblies; the generation of combustible gases such as Hydrogen; and the over-pressurization of the SFP building) and (b) the release of radiological fission products (such as Cesium and Iodine) into the environment. A simulation tool for severe accidents, MELCOR1.8.6, was used in the present analysis.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A SAM strategy for SFP using a water injection is assessed for a PWR. </LI> <LI> Loss-of-cooling/inventory accidents and different reactor operating modes are considered in the analysis. </LI> <LI> Analysis results are given for severe accident progressions and the release of fission products. </LI> <LI> Key insights obtained through the analysis are summarized from a SFP SAM position. </LI> </UL> </P>