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RISS 인기검색어
- 검색키워드
- 저자 : Ahmet Ozgur Yeniel (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
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Thrombopoietin: a novel candidate tumor marker for the diagnosis of ovarian cancer
Timucin Mermer,Mustafa Cosan Terek,Burak Zeybek,Ahmet Mete Ergenoglu,Ahmet Ozgur Yeniel,Aydın Ozsaran,Osman Zekioglu 대한부인종양학회 2012 Journal of Gynecologic Oncology Vol.23 No.2
Objective: To investigate the decisive role of preoperative serum thrombopoietin levels in the discrimination of benign and malignant ovarian pathologies and its value in the evaluation of treatment response. Methods: Fifty patients with diagnoses of adnexal masses (25 benign, 25 malignant) were included in the study. Blood samples were collected from all cases preoperatively. Age, menopausal status, adnexal mass size, preoperative CA-125 level, platelet count, the stage of the disease (FIGO stage), tumor grade, histologic subgroup, the residual tumor mass, ascites cytology,surgical procedures, and postoperative treatments were recorded for the malignant group. Response to treatment was evaluated based on the revised RECIST guideline. Results: The preoperative serum thrombopoietin levels of the malignant cases (median, 98; range, 7 to 768) were significantly higher when compared with those of benign cases (median, 27; range, 13 to 131; p=0.004). The positive predictive value of CA-125 was found to be 79%, when it was used as a single marker; however it had risen to 85% when both CA-125 and thrombopoietin levels were used. There was no significant relationship between preoperative serum thrombopoietin levels and tumor grade, ascites cytology, presence of residual mass, and response to treatment. The preoperative serum thrombopoietin levels were significantly higher in stage III-IV cases and cases with serous histology. The post-treatment serum thrombopoietin levels in the malignant group were significantly lower as compared with the preoperative thrombopoietin levels. Conclusion: Thrombopoietin can play an additive role for prediction of ovarian cancer.
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Ali Akdemir,Burak Zeybek,Levent Akman,Ahment Mete Ergenoglu,Ahmet Ozgur Yeniel,Oytun Erbas,Altug Yavasoglu,Mustafa Cosan Terek,Dilek Taskiran 대한부인종양학회 2014 Journal of Gynecologic Oncology Vol.25 No.4
Objective: To investigate whether granulocyte-colony stimulating factor (G-CSF) can decrease the extent of ovarian follicle loss caused by cisplatin treatment. Methods: Twenty-one adult female Sprague-Dawley rats were used. Fourteen rats were administered 2 mg/kg/day cisplatin by intraperitoneal injection twice per week for five weeks (total of 20 mg/kg). Half of the rats (n=7) were treated with 1 mL/kg/day physiological saline, and the other half (n=7) were treated with 100 μg/kg/day G-CSF. The remaining rats (n=7, control group) received no therapy. The animals were then euthanized, and both ovaries were obtained from all animals, fixed in 10% formalin, and stored at 4oC for paraffin sectioning. Blood samples were collected by cardiac puncture and stored at -30oC for hormone assays. Results: All follicle counts (primordial, primary, secondary, and tertiary) and serum anti-Müllerian hormone levels were significantly increased in the cisplatin+G-CSF group compared to the cisplatin+physiological saline group. Conclusion: G-CSF was beneficial in decreasing the severity of follicle loss in an experimental rat model of cisplatin chemotherapy.
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