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RISS 인기검색어
- 검색키워드
- 저자 : Ahmed K. El-Sayed (검색결과 4 건)
- 무료
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Experimental Verification of Resistance-Demand Approach for Shear of HSC Beams
Ahmed K. El-Sayed,Ahmed B. Shuraim 한국콘크리트학회 2016 International Journal of Concrete Structures and M Vol.10 No.4
The resistance-demand approach has emerged as an effective approach for determining the shear capacity of reinforced concrete beams. This approach is based on the fact that both the shear resistance and shear demand are correlated with flexural tensile strain from compatibility and equilibrium requirements. The basic shear strength, under a given loading is determined from the intersection of the demand and resistance curves. This paper verifies the applicability of resistance-demand procedure for predicting the shear capacity of high strength concrete beams without web reinforcement. A total of 18 beams were constructed and tested in four-point bending up to failure. The test variables included the longitudinal reinforcement ratio, the shear span to depth ratio, and the beam depth. The shear capacity of the beams was predicted using the proposed procedure and compared with the experimental values. The results of the comparison showed good prediction capability and can be useful to design practice.
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Experimental Verification of Resistance-Demand Approach for Shear of HSC Beams
El-Sayed, Ahmed K.,Shuraim, Ahmed B. Korea Concrete Institute 2016 International Journal of Concrete Structures and M Vol.10 No.4
The resistance-demand approach has emerged as an effective approach for determining the shear capacity of reinforced concrete beams. This approach is based on the fact that both the shear resistance and shear demand are correlated with flexural tensile strain from compatibility and equilibrium requirements. The basic shear strength, under a given loading is determined from the intersection of the demand and resistance curves. This paper verifies the applicability of resistance-demand procedure for predicting the shear capacity of high strength concrete beams without web reinforcement. A total of 18 beams were constructed and tested in four-point bending up to failure. The test variables included the longitudinal reinforcement ratio, the shear span to depth ratio, and the beam depth. The shear capacity of the beams was predicted using the proposed procedure and compared with the experimental values. The results of the comparison showed good prediction capability and can be useful to design practice.
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Emad H. M. Hassanein,Ahmed M. Sayed,Omnia A. M. Abd El-Ghafar,Zainab M. M. Omar,Eman K. Rashwan,Zuhair M. Mohammedsaleh,So Young Kyung,Jae Hyeon Park,Hyung Sik Kim,Fares E. M. Ali 대한약학회 2023 Archives of Pharmacal Research Vol.46 No.4
The present study was designed to evaluate the potential renoprotective impacts of apocynin (APC) against nephrotoxicity induced by methotrexate (MTX) administration. To fulfill this aim, rats were allocated into four groups: control; APC (100 mg/kg/day; orally); MTX (20 mg/kg; single intraperitoneal dose at the end of the 5th day of the experiment); and APC +MTX (APC was given orally for 5 days before and 5 days after induction of renal toxicity by MTX). On the 11th day, samples were collected to estimate kidney function biomarkers, oxidative stress, pro-inflammatory cytokines, and other molecular targets. Compared to the MTX control group, treatment with APC significantly decreased urea, creatinine, and KIM-1 levels and improved kidney histological alterations. Furthermore, APC restored oxidant/antioxidant balance, as evidenced by a remarkable alleviation of MDA, GSH, SOD, and MPO levels. Additionally, the iNOS, NO, p-NF-κB-p65, Ace-NF-κB-p65, TLR4, p-p38-MAPK, p-JAK1, and p-STAT-3 expressions were reduced, while the IκBα, PPAR-γ, SIRT1, and FOXO3 expressions were significantly increased. In NRK-52E cells, MTX-induced cytotoxicity was protected by APC in a concentration-dependent manner. In addition, increased expression of p-STAT-3 and p-JAK1/2 levels were reduced in MTX-treated NRK-52E cells by APC. The in vitro experiments revealed that APC-protected MTX-mediated renal tubular epithelial cells were damaged by inhibiting the JAK/STAT3 pathway. Besides, our in vivo and in vitro results were confirmed by predicting computational pharmacology results using molecular docking and network pharmacology analysis. In conclusion, our findings proved that APC could be a good candidate for MTX-induced renal damage due to its strong antioxidative and anti-inflammatory bioactivities.
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Sherif S. Ragab,Ayman M. K. Sweed,Zeinab K. Hamza,Elkhabiry Shaban,Ahmed A. El-Sayed 한국섬유공학회 2022 Fibers and polymers Vol.23 No.8
We designed and developed a novel series of bioactive disperse dyes by conjugation of spirocyclic 2-thiopyrimidine scaffold with aryl or sulfa drug moieties in the same construct through azo linker to take advantage of thebioactive character of both motifs. The target molecules were simply approached on a gram scale via the diazocoupling ofspirocyclic 2-thiouracil 1 with aryl diazonium chloride derivatives to afford the heterocyclic azo-disperse dyes 4a-e inexcellent yield. These azo dyes were effectively utilized to make pastes for silkscreen printing of polyester fabrics. The colorcharacteristics of the dyes and their fastness properties including washing, rubbing, perspiration, sublimation, and lightfastness were also investigated. The antimicrobial activity of the produced dyes 4a-e was evaluated against some Grampositiveand Gram-negative bacteria, and the results revealed that 4d was more active than the standard drug cefoperazoneagainst the Gram-positive bacteria S. aureus. The antibacterial efficacy of the treated fabrics has also been investigatedrevealing that the dyed fabric 4b was found to have a potent inhibition on B. cereus (93 %), and against E. coli with areduction of (90 %).
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