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RISS 인기검색어
- 검색키워드
- 저자 : Ahmad Mubarak Hussaini (검색결과 2 건)
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Ahmad Mubarak Hussaini,Zezi Abdulkadir Umar,Anafi Sherifat Bola,Alshargi Omar Yahya,Mohammed Mustapha,Mustapha Sagir,Bala Auwal Adam,Muhammad Surajuddeen,Julde Sa’adatu Muhammad,Wada Abubakar Sadiq,Ja 한국독성학회 2022 Toxicological Research Vol.38 No.4
The plant Combretum hypopilinum Diels (Combretaceae) has been utilized in Nigeria and other African nations to treat many diseases including liver, inflammatory, gastrointestinal, respiratory, infectious diseases, epilepsy and many more. Pharmacological investigations have shown that the plant possesses anti-infective, antidiarrhoeal, hepatoprotective, antiinflammatory, anticancer, sedative, antioxidant, and antiepileptic potentials. However, information on its toxicity profile is unavailable despite the plant's therapeutic potential. As such, this work aimed to determine the acute and sub-acute oral toxic effects of the hydromethanolic leaves extract of C. hypopilinum. The preliminary phytochemical evaluation was carried out based on standard procedures. The acute toxicity evaluation was conducted by oral administration of the extract at the dose of 5000 mg/kg based on the guideline of the Organization of Economic Co-operation and Development (OECD) 423. To investigate the sub-acute toxicity effects, the extract was administered orally to the animals daily for 28-consecutive days at the doses of 250, 500, and 1000 mg/kg. Mortality, body weight and relative organ weight were observed. The hepatic, renal, haematological, and lipid profile parameters were investigated. The liver, kidney, heart, lung, small intestine, and stomach were checked for any histopathological alterations. The results of the phytochemical investigation showed cardiac glycosides, tannins, steroids, flavonoids, alkaloids, saponins, and triterpenes. Based on the acute toxicity investigation outcome, no death and signs of toxic effects were observed. The result showed that the oral median lethal dose ( LD50) of the extract was more than the 5000 mg/kg. The extract remarkably reduced the weekly body weight of the animals at 500 mg/kg in the first and second weeks. It also significantly decreased the relative kidney weight, alkaline phosphatase, glucose, potassium, and low-density lipoprotein. There was a remarkable elevation in the percentage of eosinophils, basophils, monocytes, and granulocyte. There were histopathological abnormalities on the kidney, lung, stomach, and small intestine. The extract is relatively safe on acute exposure but moderately toxic at higher doses on sub-acute administration, particularly to the kidney.
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Aminu Musa,Idris Maje,Chindo Ben,Mubarak Hussaini Ahmad 경희대학교 융합한의과학연구소 2023 Oriental Pharmacy and Experimental Medicine Vol.23 No.3
The plant Tapinanthus globiferus has gained ethnomedicinal values to manage pain, rheumatism and cancer. The current experiment investigated the anti-nociceptive action of the ethanol extract of the plant T. globiferus (EETG) and its possible mechanisms of action. Phytochemical studies and oral median lethal dose (LD50) determination were conducted as per standard experimental protocols. The anti-nociceptive properties of the EETG (250, 500 and 1,000 mg/kg) were checked against acetic acid-elicited writhing, hot plate and formalin-produced pain models in mice. To establish the potential pathways of analgesic efects of the EETG, the animals were pre-administered with naloxone (2 mg/kg, i.p), prazosin (1 mg/kg, i.p), yohimbine (1 mg/kg, i.p), propranolol (20 mg/kg, i.p), metergoline (2 mg/kg, i.p), and glibenclamide (5 mg/kg, i.p) 30 min before the EETG (500 mg/kg) administration. The phytochemical results revealed favonoids, cardiac glycosides, phenols, steroids, saponins, tannins and triterpenes. The oral LD50 was above 5,000 mg/kg in mice. The EETG efectively (P<0.001) reduced the acetic acid-produced writhes independent of dose. Besides, it signifcantly (P<0.05, P<0.01 and P<0.001) increased the pain latency in the thermally induced pain at 30, 60, and 120 min. The EETG at 500 mg/kg efciently (P<0.05) declined the second stage of formalin-caused pain response in comparison to the control animals. The pre-administration of the naloxone, prazosin and metergoline to the mice reversed the anti-nociceptive efect elicited by the EETG in the formalinproduced pain in the second stage. The experimental outcomes have revealed that the plant Tapinanthus globiferus possesses analgesic activity which could be related to the opioidergic, α1-adrenergic and serotonergic pathways.
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