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        Effect of tuberculosis treatment on leptin levels, weight gain, and percentage body fat in Indonesian children

        Mexitalia, Maria,Dewi, Yesi Oktavia,Pramono, Adriyan,Anam, Mohammad Syarofil The Korean Pediatric Society 2017 Clinical and Experimental Pediatrics (CEP) Vol.60 No.4

        Purpose: Tuberculosis (TB) remains a problem in the community. TB patients usually experience malnutrition, which is characterized by both decreased body weight (BW) and body fat percentage (BFP). Leptin, an important regulator of BW, also plays an important role in cellular immunity, which is integral to defense against Mycobacterium tuberculosis infection. We analyzed the effect of an anti-TB treatment regimen on the leptin level, BW, and BFP of children with TB. Methods: The design of this study was a group interrupted time series. The subjects were children with probable TB according to clinical criteria based on an Indonesian scoring system adopted from the Consensus of Expert Panel. BW; BFP; energy intake; fat and protein intake; and leptin levels before, 2 months after (intensive phase), and 6 months after (continuation phase) anti-TB treatment, were measured. About 40 children, aged 5-14 years, participated in this study. Results: The BW, BFP and leptin level increased from before treatment to after completion of the intensive phase and still showed an increased during the continuation phase: BW 18.65 kg, 19.75 kg, and 20.85 kg; BFP 18.3%, 19.5%, and 20.2%; and leptin level 1.9 mg/dL, 3.07 mg/dL, and 3.4 mg/dL, respectively (P<0.01). Conclusion: Leptin level, BW, and BFP increased throughout the course of anti-TB treatment, compared with pretreatment values. Further research is needed to compare the results with data for healthy children.

      • KCI등재

        Effect of tuberculosis treatment on leptin levels, weight gain, and percentage body fat in Indonesian children

        Maria Mexitalia,Yesi Oktavia Dewi,Adriyan Pramono,Mohammad Syarofil Anam 대한소아청소년과학회 2017 Clinical and Experimental Pediatrics (CEP) Vol.60 No.4

        Purpose: Tuberculosis (TB) remains a problem in the community. TB patients usually experience malnutrition, which is characterized by both decreased body weight (BW) and body fat percentage (BFP). Leptin, an important regulator of BW, also plays an important role in cellular immunity, which is integral to defense against Mycobacterium tuberculosis infection. We analyzed the effect of an anti-TB treatment regimen on the leptin level, BW, and BFP of children with TB. Methods: The design of this study was a group interrupted time series. The subjects were children with probable TB according to clinical criteria based on an Indonesian scoring system adopted from the Consensus of Expert Panel. BW; BFP; energy intake; fat and protein intake; and leptin levels before, 2 months after (intensive phase), and 6 months after (continuation phase) anti-TB treatment, were measured. About 40 children, aged 5–14 years, participated in this study. Results: The BW, BFP and leptin level increased from before treatment to after completion of the intensive phase and still showed an increased during the continuation phase: BW 18.65 kg, 19.75 kg, and 20.85 kg; BFP 18.3%, 19.5%, and 20.2%; and leptin level 1.9 mg/dL, 3.07 mg/dL, and 3.4 mg/dL, respectively (P<0.01). Conclusion: Leptin level, BW, and BFP increased throughout the course of anti-TB treatment, compared with pretreatment values. Further research is needed to compare the results with data for healthy children.

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        Design of double dynamic vibration absorbers for reduction of two DOF vibration system

        Lovely Son,Mulyadi Bur,Meifal Rusli,Adriyan 국제구조공학회 2016 Structural Engineering and Mechanics, An Int'l Jou Vol.57 No.1

        This research is aimed to design and analyze the performance of double dynamic vibration absorber (DVA) using a pendulum and a spring-mass type absorber for reducing vibration of two-DOF vibration system. The conventional fixed-points method and genetics algorithm (GA) optimization procedure are utilized in designing the optimal parameter of DVA. The frequency and damping ratio are optimized to determine the optimal absorber parameters. The simulation results show that GA optimization procedure is more effective in designing the double DVA in comparison to the fixed-points method. The experimental study is conducted to verify the numerical result.

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