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RISS 인기검색어
- 검색키워드
- 저자 : Adnan Aydin (검색결과 3 건)
- 무료
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Aydiner, Adnan,Yildiz, Ibrahim,Seyidova, Avesta Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5
Background: The efficacy of erlotinib is controversial in patients with unknown EGFR mutational status. The aim of this study was to identify the clinicopathological factors that are predictive of erlotinob treatment outcomes for NSCLC patients with unknown EGFR mutational status. Materials and Methods: A retrospective analysis of 109 patients with advanced NSCLC who had previously failed at least one line of chemotherapy and received subsequent treatment with erlotinib (150 mg/day orally) was performed. A Cox proportional hazard model for univariate and multivariate analyses was used to identify the baseline clinical parameters correlating with treatment outcome, expressed in terms of hazard ratios (HRs) and 95% confidence intervals. Results: The median treatment duration was 15 weeks (range, 4-184). The disease control rate was 55%, including disease stability for ${\geq}3$ months for 40% of the patients. Median progression-free survival and median overall survival (OS) were 4.2 and 8.5 months, respectively. The Cox model indicated that an Eastern Cooperative Oncology Group performance status (ECOG PS) ${\geq}2$ (HR 3.82; p<0.001), presence of intra-abdominal metastasis (HR 3.42; p=0.002), 2 or more prior chemotherapy regimens (HR 2.29; p=0.021), and weight loss >5% (HR 2.05; p=0.034) were independent adverse prognostic factors for OS in NSCLC patients treated with erlotinib. Conclusions: This study suggests that NSCLC patients should be enrolled in erlotinib treatment after a first round of unsuccessful chemotherapy to improve treatment success, during which they should be monitored for intra-abdominal metastasis and weight loss.
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Aydiner, Adnan,Ciftci, Rumeysa,Karabulut, Senem,Kilic, Leyla Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10
Aim: To determine whether beta-blockers (BBs) improve the overall survival (OS) of patients with metastatic non-small cell lung cancer (NSCLC). Materials and Methods: The medical charts of 107 patients with metastatic NSCLC were retrospectively assessed. Thirty-five patients (BB group) using BBs during chemotherapy (CT) were compared with 72 controls [control=(C) group] who did not use BBs following the diagnosis of NSCLC. The histological tumor subtype, performance status (ECOG), age, gender, smoking status, comorbidities, other medications and chemotherapeutics that were received in any line of treatment were recorded. We compared the overall survival (OS) of the patients in the BB and C groups. Results: The mean age of the patients was 61 years (range 42-81 years) and all patients were administered CT. The BB group was more likely to have HT and IHD and was more likely to use RAS blockers (p<0.01 for all) compared with the C group, as expected. The mean follow-up time was 17.8 months (range 1-102 months) for the entire group. The most commonly prescribed BB agent was metoprolol (80% of cases). At the time of the analysis, 74 (69%) of all patients had died. In the univariate analysis the median overall survival (OS) was 19.25 (${\pm}2.87$) months (95%CI: 13.62-24.88) in the BB group and 13.20 (${\pm}2.37$) months (95%CI: 8.55-17.85) in the C group (p=0.017). However, the benefit of BBs on survival disappeared in the multivariate analysis. Conclusions: The use of BBs during CT may be associated with an improved OS for patients with metastatic NSCLC.
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Constitutive Behavior of Binary Mixtures of Kaolin and Glass Beads in Direct Shear
Yanrong Li,Adnan Aydin,Qiang Xu,Jun Chen 대한토목학회 2012 KSCE Journal of Civil Engineering Vol.16 No.7
Composite soils having a wide range of particle size may be the most commonly encountered materials in geotechnical engineering practice. This study involves 21 direct shear tests to investigate the constitutive behavior of composite soils within the normal stress range from 50 to 200 kPa. The samples are mixtures of fine (kaolin) and coarse (glass beads) fractions at various proportions. The properties of the samples considered in the investigation are particle size distribution, water content of sheared specimens, structural features of shear surface and residual shear strength. It is shown that the particle size distribution influences the void ratio produced with the same compaction effort. Increasing fine fraction from zero to a threshold value (approximately 20-30%)causes a decrease in void ratio of the mixture. Beyond this threshold, a further increase of fine fraction causes an increase in void ratio. High proportion of fine fraction causes: (1) lower water content of shear zones relative to outer zones, (2) densification process within shear zone, (3) well slickensided shear surfaces, and (4) shearing in sliding mode and hence low residual shear strength.
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