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( Malik Adeel Umer ),( Dong Ju Lee ),( Ho Jin Ryu ),( Soon Hyung Hong ) 한국복합재료학회 2015 Composites research Vol.28 No.6
In order to improve the mechanical properties of tungsten at room and elevated temperature, hafnium carbide (HfC) reinforced tungsten matrix composites were prepared using the spark plasma sintering technique. The effect of HfC content on the compressive strength and flexural strength of the tungsten composites was investigated. Mechanical properties of the composites were also measured at elevated temperatures and their trends, with varying reinforcement volume fraction, were studied. The effect of reinforcement fraction on the thermal properties of the composites was investigated. The thermal conductivity and diffusivity of the composites decreased with increasing temperature and reinforcement volume fraction. An inherently low thermal conductivity of the reinforcement as well as interfacial losses was responsible for lower values of thermal conductivity of the composites. Values of coefficient of thermal expansion of the composites were observed to increase with HfC volume fraction.
Malik Adeel Umer,Dongju Lee,Owais Ahmed Waseem,Ho Jin Ryu,Soon Hyung Hong 대한금속·재료학회 2016 METALS AND MATERIALS International Vol.22 No.3
SiC reinforced tungsten matrix composites were fabricated via the spark plasma sintering process. In order to prevent an interfacial reaction between the SiC and tungsten during sintering, TiOx coated SiC particles were synthesized by a solution-based process. TiOx layer coated SiC particles were treated in high temperature nitriding conditions or annealed in a high temperature vacuum to form TiN or TiC coated SiC particles, respectively. The TiC layers coated on SiC particles successfully prevented tungsten from reacting with SiC; hence the proposed process resulted in successful fabrication of the SiC/W composites. The mechanical properties such as compressive strength and flexural strength of the composites were measured. Additionally, the effect of SiC on the high temperature oxidative ablation of tungsten was also investigated. The addition of SiC resulted in an improved oxidative ablation resistance of the tungsten-based composites.
On the Effects of Subpacketization in Content-Centric Mobile Networks
Malik, Adeel,Lim, Sung Hoon,Shin, Won-Yong IEEE 2018 IEEE journal on selected areas in communications Vol.36 No.8
<P>A large-scale content-centric mobile ad hoc network employing <I>subpacketization</I> is studied in which each mobile node having finite-size cache moves according to the <I>reshuffling mobility model</I> and requests a content object from the library independently at random according to the Zipf popularity distribution. Instead of assuming that one content object is transferred in a single time slot, we consider a more challenging scenario where the size of each content object is considerably large and thus only a subpacket of a file can be delivered during one time slot, which is motivated by a <I>fast mobility</I> scenario. Under our mobility model, we consider a single-hop-based content delivery and characterize the fundamental tradeoffs between throughput and delay. The order-optimal throughput–delay tradeoff is analyzed by presenting the following two content reception strategies: the sequential reception for uncoded caching and the random reception for maximum distance separable (MDS)-coded caching. We also perform numerical evaluation to validate our analytical results. In particular, we conduct performance comparisons between the uncoded caching and the MDS-coded caching strategies by identifying the regimes in which the performance difference between the two caching strategies becomes prominent with respect to system parameters such as the Zipf exponent and the number of subpackets. In addition, we extend our study to the random walk mobility scenario and show that our main results are essentially the same as those in the reshuffling mobility model.</P>
A comprehensive in silico analysis of sortase superfamily
Adeel Malik,Seung Bum Kim 한국미생물학회 2019 The journal of microbiology Vol.57 No.6
Sortases are cysteine transpeptidases that assemble surface proteins and pili in their cell envelope. Encoded by all Grampositive bacteria, few Gram-negative bacteria and archaea, sortases are currently divided into six classes (A-F). Due to the steep increase in bacterial genome data in recent years, the number of sortase homologues have also escalated rapidly. In this study, we used protein sequence similarity networks to explore the taxonomic diversity of sortases and also to evaluate the current classification of these enzymes. The resultant data suggest that sortase classes A, B, and D predominate in Firmicutes and classes E and F are enriched in Actinobacteria, whereas class C is distributed in both Firmicutes and Actinobacteria except Streptomyces family. Sortases were also observed in various Gram-negatives and euryarchaeota, which should be recognized as novel classes of sortases. Motif analysis around the catalytic cysteine was also performed and suggested that the residue at 2nd position from cysteine may help distinguish various sortase classes. Moreover, the sequence analysis indicated that the catalytic arginine is highly conserved in almost all classes except sortase F in which arginine is replaced by asparagine in Actinobacteria. Additionally, class A sortases showed higher structural variation as compared to other sortases, whereas inter-class comparisons suggested structures of class C and D2 exhibited best similarities. A better understanding of the residues highlighted in this study should be helpful in elucidating their roles in substrate binding and the sortase function, and successively could help in the development of strong sortase inhibitors.
Expression of Transthyretin during bovine myogenic satellite cell differentiation.
Pokharel, Smritee,Kamli, Majid Rasool,Mir, Bilal Ahmad,Malik, Adeel,Lee, Eun Ju,Choi, Inho Springer 2014 In vitro cellular & developmental biology Animal Vol.50 No.8
<P>Adult myogenesis responsible for the maintenance and repair of muscle tissue is mainly under the control of myogenic regulatory factors (MRFs) and a few other genes. Transthyretin gene (TTR), codes for a carrier protein for thyroxin (T4) and retinol binding protein bound with retinol in blood plasma, plays a critical role during the early stages of myogenesis. Herein, we investigated the relationship of TTR with other muscle-specific genes and report their expression in muscle satellite cells (MSCs), and increased messenger RNA (mRNA) and protein expression of TTR during MSCs differentiation. Silencing of TTR resulted in decreased myotube formation and decreased expression of myosin light chain (MYL2), myosin heavy chain 3 (MYH3), matrix gla protein (MGP), and voltage-dependent L type calcium channel (Cav1.1) genes. Increased mRNA expression observed in TTR and other myogenic genes with the addition of T4 decreased significantly following TTR knockdown, indicating the critical role of TTR in T4 transportation. Similarly, decreased expression of MGP and Cav1.1 following TTR knockdown signifies the dual role of TTR in controlling muscle myogenesis via regulation of T4 and calcium channel. Our computational and experimental evidences indicate that TTR has a relationship with MRFs and may act on calcium channel and related genes.</P>