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Adam Burr(Adam Burr ),Paul Harari(Paul Harari ),Aaron Wieland(Aaron Wieland ),Randall Kimple(Randall Kimple ),Gregory Hartig(Gregory Hartig ),Matthew Witek(Matthew Witek ) 대한방사선종양학회 2022 Radiation Oncology Journal Vol.40 No.4
Purpose: Optimal radiotherapy treatment volumes for patients with locally advanced hypopharynx squamous cell carcinoma should ensure maximal tumor coverage with minimal inclusion of normal surrounding structures. Here we evaluated the effectiveness of a direct 3-mm high-dose gross tumor volume to planning target volume expansion on clinical outcomes for hypopharynx cancers. Materials and Methods: We performed a retrospective analysis of patients with hypopharynx carcinoma treated between 2004 and 2018 with primary radiotherapy using a direct high-dose gross tumor volume to planning target volume expansion and with or without concurrent systemic therapy. Diagnostic imaging of recurrences was co-registered with the planning CT. Spatial and volumetric analyses of contoured recurrences were compared with planned isodose lines. Failures were initially defined as in field, marginal, elective nodal, and out of field. Each failure was further classified as central high-dose, peripheral high-dose, central intermediate/low-dose, peripheral intermediate/low-dose, and extraneous. Clinical outcomes were analyzed by Kaplan-Meier estimation. Results: Thirty-six patients were identified. At a median follow-up at 52.4 months, estimated 5-year overall survival was 59.3% (95% confidence interval [CI], 36.3%–74.1%), 5-year local and nodal control was 71.7% (95% CI, 47.1%–86.3%) and 69.9% (95% CI, 57.0%–82.6%), respectively. The most common failure was in the high-dose primary target volume. The gastrostomy tube retention rate at 1 year among patients without recurrence was 13.0% (95% CI, 3.2%–29.7%). Conclusion: Minimal high-dose target volume expansions for hypopharynx cancers were associated with favorable locoregional control. This approach may enable therapy intensification to improve clinical outcomes.
Cariprazine — an Alternative Treatment for Clozapine-resistant Schizophrenia?
Adam Montgomery(Adam Montgomery ),Marianna Rogowska(Marianna Rogowska ),Luiz Dratcu(Luiz Dratcu ) 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1
Treatment-resistant schizophrenia (TRS) poses a significant therapeutic challenge in psychiatric practice. Clozapine is recognized as a treatment of choice in TRS but is not always effective in alleviating patients’ symptoms. Additionally, clozapine therapy is associated with multiple side effects and monitoring requirements that often limit its use and negatively affect patients’ compliance with the treatment. Although clozapine augmentation options are available, there is currently no alternative monotherapy proven to be effective in TRS. We present a case of a young man with TRS who failed to respond to appropriate trials of risperidone, aripiprazole and also clozapine, and who experienced impairing adverse effects of clozapine that made further clozapine treatment not only futile but also detrimental to his health. He was successfully treated with cariprazine monotherapy, which culminated in the remission of his both positive and negative symptoms of psychosis as well as in the marked improvement in social functioning. Cariprazine, a newer atypical antipsychotic endowed with a D3-preferring mode of action, may offer a better tolerated and more acceptable treatment option for patients with difficult-to-treat psychotic symptoms.
Rings in which every ideal contained in the set of zero-divisors is a d-ideal
Adam Anebri,Najib Mahdou,Abdeslam Mimouni 대한수학회 2022 대한수학회논문집 Vol.37 No.1
In this paper, we introduce and study the class of rings in which every ideal consisting entirely of zero divisors is a d-ideal, considered as a generalization of strongly duo rings. Some results including the characterization of AA-rings are given in the first section. Further, we examine the stability of these rings in localization and study the possible transfer to direct product and trivial ring extension. In addition, we define the class of $d_E$-ideals which allows us to characterize von Neumann regular rings.
Adam, J.,Adamová,, D.,Aggarwal, M. M.,Rinella, G. Aglieri,Agnello, M.,Agrawal, N.,Ahammed, Z.,Ahmed, I.,Ahn, S. U.,Aimo, I.,Aiola, S.,Ajaz, M.,Akindinov, A.,Alam, S. N.,Aleksandrov, D.,Alessandr Springer Berlin Heidelberg 2015 European Physical Journal C Vol.75 No.5
<P>The measurement of primary [FORMULA OMISSION], [FORMULA OMISSION], [FORMULA OMISSION] and [FORMULA OMISSION] production at mid-rapidity ([FORMULA OMISSION] 0.5) in proton–proton collisions at [FORMULA OMISSION][FORMULA OMISSION] 7 TeV performed with a large ion collider experiment at the large hadron collider (LHC) is reported. Particle identification is performed using the specific ionisation energy-loss and time-of-flight information, the ring-imaging Cherenkov technique and the kink-topology identification of weak decays of charged kaons. Transverse momentum spectra are measured from 0.1 up to 3 GeV/[FORMULA OMISSION] for pions, from 0.2 up to 6 GeV/[FORMULA OMISSION] for kaons and from 0.3 up to 6 GeV/[FORMULA OMISSION] for protons. The measured spectra and particle ratios are compared with quantum chromodynamics-inspired models, tuned to reproduce also the earlier measurements performed at the LHC. Furthermore, the integrated particle yields and ratios as well as the average transverse momenta are compared with results at lower collision energies.</P>
Adam, Ihab,Taha, Mahmoud M. Reda Korea Concrete Institute 2011 International Journal of Concrete Structures and M Vol.5 No.2
Modeling creep of concrete has been one of the most challenging problems in concrete. Over the years, research has proven the significance of creep and its ability to influence structural behavior through loss of prestress, violation of serviceability limit states or stress redistribution. Because of this, interest in modeling and simulation of creep has grown significantly. A research program was planned to investigate the significance of different factors affecting creep of concrete. This research investigation is divided into two folds: first, an in-depth study of the RILEM creep database and development of a homogenous database that can be used for blind computational analysis. Second: developing a probabilistic Bayesian screening method that enables identifying the significance of the different factors affecting creep of concrete. The probabilistic analysis revealed a group of interacting parameters that seem to significantly influence creep of concrete.
Adam Tabbaa,Mina Shaker,Rocio Lopez,Kazem Hoshemand,Valerio Nobili,Naim Alkhouri 대한소아소화기영양학회 2015 Pediatric gastroenterology, hepatology & nutrition Vol.18 No.3
Purpose: Recent studies have suggested that decreased serum potassium level may contribute to various metabolic disorders in adult patients including nonalcoholic fatty liver disease (NAFLD). We aimed to study the correlation between serum potassium levels and the histologic severity of NAFLD in children. Methods: Pediatric patients with biopsy-proven NAFLD were included in this study. Demographic, clinical, and histo-pathological data were obtained. Multivariable logistic regression analysis was used to assess whether potassium levels are associated with the presence of nonalcoholic steatohepatitis (NASH) or fibrosis after adjusting for possible confounders. A p-value <0.05 was considered statistically significant. Results: Among 125 biopsies, 49.6% (62) had evidence of NASH while 66.4% (83) had some degree of fibrosis (stage 1-3). Mean serum potassium was significantly lower in NASH group as compared to non-NASH group (4.4±0.42mmoL/L vs. 4.8±0.21, p<0.001). Higher potassium level had negative correlation with presence of steatosis, balloon-ing, lobular inflammation, fibrosis and NAFLD activity score (p<0.05). On multivariable analysis and after adjusting for the metabolic syndrome and insulin resistance, higher potassium level was significantly associated with lower likelihood of having a histological diagnosis of NASH on biopsy (odds ratio [OR], 0.12; 95% confidence interval [95% CI], 0.05-0.28; p<0.001). Similarly, the likelihood of having fibrosis decreases by 76% for every 0.5 mmoL/L increase in potassium (OR ,0.24; 95% CI, 0.11-0.54; p<0.001).Conclusion: Our study shows an inverse relationship between serum potassium levels and the presence of ag-gressive disease (NASH and fibrosis) in children with NAFLD.
Inclusive quarkonium production at forward rapidity in pp collisions at [FORMULA OMISSION] TeV
Adam, J.,Adamová,, D.,Aggarwal, M. M.,Aglieri Rinella, G.,Agnello, M.,Agrawal, N.,Ahammed, Z.,Ahn, S. U.,Aiola, S.,Akindinov, A.,Alam, S. N.,Aleksandrov, D.,Alessandro, B.,Alexandre, D.,Alfaro M Springer Berlin Heidelberg 2016 The European physical journal. C, Particles and fi Vol.76 No.4
<P>We report on the inclusive production cross sections of [FORMULA OMISSION], [FORMULA OMISSION], [FORMULA OMISSION](1S), [FORMULA OMISSION](2S) and [FORMULA OMISSION](3S), measured at forward rapidity with the ALICE detector in [FORMULA OMISSION] collisions at a center-of-mass energy [FORMULA OMISSION] TeV. The analysis is based on data collected at the LHC and corresponds to an integrated luminosity of 1.23 pb[FORMULA OMISSION]. Quarkonia are reconstructed in the dimuon-decay channel. The differential production cross sections are measured as a function of the transverse momentum [FORMULA OMISSION] and rapidity <I>y</I>, over the [FORMULA OMISSION] ranges [FORMULA OMISSION] GeV/<I>c</I> for [FORMULA OMISSION], [FORMULA OMISSION] GeV/<I>c</I> for all other resonances, and for [FORMULA OMISSION]. The cross sections, integrated over [FORMULA OMISSION] and <I>y</I>, and assuming unpolarized quarkonia, are [FORMULA OMISSION] [FORMULA OMISSION]b, [FORMULA OMISSION] [FORMULA OMISSION]b, [FORMULA OMISSION] nb, [FORMULA OMISSION] nb and [FORMULA OMISSION] nb, where the first uncertainty is statistical and the second one is systematic. These values agree, within at most [FORMULA OMISSION], with measurements performed by the LHCb collaboration in the same rapidity range.</P>
Numerical analysis of Brazilian split test on concrete cylinder
Adam Wosatko,Andrzej Winnicki,Jerzy Pamin 사단법인 한국계산역학회 2011 Computers and Concrete, An International Journal Vol.8 No.3
The paper presents simulations of the Brazilian test using two numerical models. Both models are regularized in order to obtain results independent of discretization. The first one, called gradient damage, is refined by additional averaging equation which contains gradient terms and an internal length scale as localization limiter. In the second one, called viscoplastic consistency model, the yield function depends on the viscoplastic strain rate. In this model regularization properties are governed by the assumed strain rate. The two models are implemented in the FEAP finite element package and compared in this paper. Parameter studies of the split test are performed in order to point out the features of each model.