COVID-19 as a Recognized Work-Related Disease: The Current Situation Worldwide

Sandal, Abdulsamet,Yildiz, Ali N. Occupational Safety and Health Research Institute 2021 Safety and health at work Vol.12 No.1

Coronavirus disease 2019 (COVID-19), which is a newly emerging infectious disease worldwide, can be categorized as an occupational disease, because employees, particularly in the healthcare system, can be infected at the workplace. As of December 15, 2020, we summarized the occupational safety and health practices in selected countries on the recognition of COVID-19 as one of the occupational risks. The situation has differed among countries, including the recognition status and whether a specific regulation existed. International organizations, namely the International Labour Organization, World Health Organization, and European Union, should plan and conduct studies on the work-relatedness of COVID-19, propose criteria for recognition, and add the infection to the occupational disease list to provide a basis for specific country regulations. Stakeholders should also act to adjust country-level legislation.

Poster Session : PS 0746 ; Rheumatology ; Frequency of Radiological Hip Involvement and total Hip Replacement in A Large Single Center Spondyloarthritis Cohort with Biological Treatments: HUr-BIo Real Life Results.

( Umut Kalyoncu ),( Abdulsamet Erden ),( Omer Karadag ),( Levent Kilic ),( Sule Apras Bilgen ),( Ali Akdogan ),( Ali Ihsan Ertenli ),( Sedat Kiraz ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Total hip replacement (THR) is a favorable treatment option for severe ankylosing spondylitis (AS). Objective of this study was to assess frequency of THR and hip involvement in a single center spondyloarthritis (SpA) biological dataset. Methods: HUR-BIO(Hacettepe University Rheumatology Biologic Registry) is a single center biological registry since 2005. HUR-BIO biological data set included demographic data, co-morbidities, smoking status, baseline and follow-up disease activity parameters (such as BASDAI, BASfi, CRP, ESR). Available digital radiographic imaging of pelvis were reassesed for hip inolvement and THR. Kaplan-Meier plots and log rank tests were used to assess TNfi drug survival. Results: 768 of 1290 (59. 5%) SpA patients had available pelvis radiography. 450 of 768 (58. 6%) patients were male and mean age was 41±11 years old, mean disease duration 8. 6±6. 9 years, mean TNfi duration was 32±29 months. Frequency of hip involvement in spondyloarthritis is in Table 1. Radiological hip involvement and severe hip involvement found in 125 (16. 3%) and 65 (8. 4%) patients, respectively. Patients with severe hip involvement was older age 47±11 vs 41±11, p<0. 001, more disease duration 15±9 vs 8±6 years, p<0. 001, more frequently male 47/65(72. 3%) vs 402/702 (57. 3), p=0. 018), more frequently advanced spinal disease 18/52 (34. 6%) vs 74/576 (12. 8%), p<0. 001. Baseline disease activity parameters were similar with and without severe hip involvement, however, last visit CRP (2. 56±2. 75 vs 1. 06±1. 97 mg/dl, p<0. 001), ESR (24±25 vs 13±14 mm/hour, p<0. 001) and BASfi (4. 7±2. 8 vs 2. 4±2. 1, p<0. 001) were higher in severe hip involvement. Disease duration was found independent risk factor for severe hip inolvement (OR 1. 13(95%CI 1. 09-1. 17). In all spondyloarthritis patients, TNfi drug survival was similar with and without severe hip involvement. Conclusions: Severe hip involvemet was demonstrated either AS or other spondyloarthritis. THR performed almost 5 percent of AS, PsA and enteropathtic arthritis. On the other hand, substantial of AS patients who need THR were not operated yet. The reasons of this delay may be responsible of patients` perspective or physicians. TNfi may not refi ect any major unfavotrable effect of THR.

Poster Session : PS 0716 ; Rheumatology ; Ocular Toxicity of Hydroxychloroquine is More Frequent in Male Patients

( Omer Karadag ),( Abdulsamet Erden ),( Levent Kilic ),( Umut Kalyoncu ),( Ali Akdogan ),( Sule Apras Bilgen ),( Sedat Kiraz ),( Ihsan Ertenli ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Hydroxychloroquine(HQ) is widely used to treat for rheumatoid arthritis( RA) and connectice tissue disorders. Due to the potential of ocular toxicity,routine ophtalmological assessment(ROA) is essential for sight safety. Methods: In our outpatient clinic, patients with RA and connective tissue disorders such as systemic lupus erythematosus (SLE), sjogren syndorme (SS) and overlap were assessed consecutively for drug status of HQ by a standard questionnaire between December 2013 and January 2014. Patients who used HQ less than 1 year (13. 6%) were excluded from study. Ocular toxicity was taken from patients` reported. If ophthalmologist advised to cease HQ due to ocular toxicity,we accepted as ocular side effect. Patients with ocular toxicity were not reevaluated by an ophthalmologist. Cumulative HQ dosage and risk factors for ocular toxicity were assessed by using Mann-Whitney U test. Results: A total of 266 patients(90. 6% female) were enrolled. Mean age was 50±13. 5 years and median disease duration was 8 years(1-50). Median duration of HQ treatment was 6 years(1-28) and median dose was 400 mg/day. Of 46(17. 3%) patients were ceased HQ. The reasons of cease of HQ were ocular toxicity 22(47. 8%), patient non-adherence 9(19. 6%),dermatological side effect 3(6. 5%),others 12(26. 1%). 22 of all 266(%8. 3) patients developed ocular toxicity. Ocular toxicity was found more frequently in male 5/20(20%) vs 17/241(7%),p=0. 025). Median cumulative HQ dosage in patients with ocular toxicity was 864 gram (108-2160) in other words 12. 9 gr per kilogram( 1. 2-40). Older age (58±10 vs 50±13,p=0. 008),longer disease duration (14. 8±11. 5 vs 9. 2±7. 1 years,p=0. 013), and longer HQ duration (10±6. 3 vs 7. 1±5. 6 years,p=0. 023)were associated with ocular toxicity. Conclusions: Among regularly follow-up patients, ocular toxicity of HQ was not rare in a rheumatology outpatient clinic. Cumulative toxicity for ocular toxicity was 13 gram/kilogram;however, certain patients developed toxicity in 1 gram/kg/day. Although, important part of our patients was female, ocular toxicity was seen more frequently in male patients. Other risk factors such as longer disease duration,longer HQ usage and older age were also demonstrated in our patients.

Methodology to Detect Bus Stop Influence Zones Utilizing Facebook Prophet Changepoint Detection Method

Abdullah Maltas,Halit Ozen,Abdulsamet Saracoglu 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.10

Travel time of buses, a major part of the urban public transit system, is affected by various factors and foremost are the bus stops. In addition to the dwell time at the stop, the deceleration and acceleration zones reduce average speed, particularly in mixed traffic, and increase travel time. Several approaches are used in estimating the link-based travel time of public transit systems in transportation planning, but Bus Stop Influence Zones (BSIZs) are ignored. Moreover, fuel consumption and pollutant emissions increase in BSIZs, and this demonstrates the importance of BSIZs in measuring the performance of public transit systems as well as planning. Data obtained from the Automatic Vehicle Location system was used and visualized on Geographic Information System and data preprocessing steps were performed. Finally, changepoint detection method of Facebook Prophet (FBP-CDM) was exploited to identify changepoints in location-speed data on the selected route. Results were validated with real-life data and expert opinion, and then compared with the findings acquired by the K-means clustering. Based on the conclusions, FBP-CDM was found quite effective in detecting and predicting BSIZs accurately and the proposed methodology is useful for studies in transportation planning and operations.

Survival Analysis of Biliary Tract Cancer Cases in Turkey

Akca, Zeki,Mutlu, Hasan,Erden, Abdulsamet,Buyukcelik, Abdullah,Cihan, Yasemin Benderli,Goksu, Sema Sezgin,Aslan, Tuncay,Sezer, Emel Yaman,Inal, Ali Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15

Background: Because of the relative rarity of biliary tract cancers (BTCs), defining long term survival results is difficult. In the present study, we aimed to evaluate the survival of a series of cases in Turkey. Materials and Methods: A totally of 47 patients with billiary tract cancer from Mersin Goverment Hospital, Acibadem Kayseri Hospital and Kayseri Training and Research Hospital were analyzed retrospectively using hospital records between 2006-2012. Results: The median overall survival was $19.3{\pm}3.9$ months for all patients. The median disease free and overall survivals were $24.3{\pm}5.3$ and $44.1{\pm}12.9$ months in patients in which radical surgery was performed, but in those with with inoperable disease they were only $5.3{\pm}1.5$ and $10.7{\pm}3.2$ months, respectively. Conclusions: BTCs have a poor prognosis. Surgery with a microscopic negative margin is still the only curative treatment.

Lack of Sunlight Exposure Influence on Primary Glioblastoma Survival

Mutlu, Hasan,Akca, Zeki,Erden, Abdulsamet,Aslan, Tuncay,Ucar, Kadir,Kaplan, Bunyamin,Buyukcelik, Abdullah Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.10

Background: The prognosis of primary glioblastoma (GBM) is poor. Approximately 2/3 of primary brain tumor diagnoses are GBM, of which 95% are primary lesions. In this study, we aimed to evaluate whether more sunlight exposure has an effect on survival of patients with primary GBM. Materials and Methods: A total of 111 patients with primary GBM were enrolled from Kayseri in inner Anatolia which has a cold climate (n: 40) and Mersin in Mediterranean region with a warm climate and more sunlight exposure (n: 71). The patients with primary GBM were divided into two groups as Kayseri and Mersin and compared for progression free survival (PFS) and overall survival (OS).Results: The PFS values were 7.0 and 4.7 months for Kayseri and Mersin groups, respectively (p=0.10) and the repsective OS values were 13.3 and 9.4 months (p=0.13). We did not found any significant difference regarding age, sex, comorbidity, smoking, surgery, resurgery, adjuvant chemoradiotherapy and palliative chemotherapy between the groups. Conclusions: We found that more sunlight exposure had no impact on prognosis of patients with primary GBM, adding inconsistency to the literature about the relationship between sunlight and GBM.

Relationship between Colonic Polyp Type and the Neutrophil/Lymphocyte Ratio as a Biomarker

Karaman, Hatice,Karaman, Ahmet,Erden, Abdulsamet,Poyrazoglu, Orhan Kursat,Karakukcu, Cigdem,Tasdemir, Arzu Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5

Aim: We designed this study to investigate the neutrophil lymphocyte ratio as a biomarker in distinguishing colonic polyps which are neoplastic or non-neoplastic. Materials and Methods: One hundred and twenty-five patients with colonic polyps were enrolled into the study. The following data were obtained from a computerized patient registry database: mean platelet volume (MPV), uric acid (UA), platelet count (PC), alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT) and the neutrophil to lymphocyte ratio (NLR). Exclusion criteria were active infectious disease, hematological disorders, and malignancies. Colonic polyps divided into two groups as neoplastic polyps (tubular adenoma, villous adenoma, tubulovillous adenoma) and non-neoplastic polyps (hyperplastic polyps, inflammatory pseudopolyps etc). The relationship between colonic polyp type and NLR was evaluated with statistical analysis. Results: There were 67 patients (53.6%) with neoplastic and 58 (46.4%) patients with non-neoplastic polyps. Mean NLRs of neoplastic and non-neoplastic groups were respectively $3.32{\pm}2.54$ and $2.98{\pm}3.16$ (P<0.05). Conclusion: Although sensitivity and specificity are not high, NLR may be used as a biomarker of neoplastic condition of colonic polyps.

Staging with PET-CT in Patients with Locally Advanced Non Small Cell Lung Cancer is Superior to Conventional Staging Methods in Terms of Survival

Mutlu, Hasan,Buyukcelik, Abdullah,Erden, Abdulsamet,Aslan, Tuncay,Akca, Zeki,Kaya, Eser,Kibar, Mustafa,Seyrek, Ertugrul,Yavuz, Sinan,Calikusu, Zuleyha Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6

Background: Of patients with non small cell lung cancer (NSCLC), around one third are locally advanced at the time of diagnosis. Because only a proprotion of stage III patients can be cured by surgery, in order to improve the outcomes, sequential or concurrent chemoradiation, or concurrent chemoradiation with induction or consolidation is offered to the patients with locally advanced NSCLC. Today, PET combined with computerized tomography (PET-CT) is accepted as the most sensitive technique for detecting mediastinal lymph node and extracranial metastases from NSCLC. We aimed to compare PET-CT and conventional staging procedures for decisions regarding curative treatment of locally advanced NSCLC. Materials and Methods: A total of 168 consecutive patients were included from Acibadem Kayseri Hospital, Acibadem Adana Hospital and Kayseri Research and Training Hospital in this study. Results: While the median PFS was $13.0{\pm}1.9$ months in the PET-CT group, it was only $6.0{\pm}0.9$ in the others (p<0.001). The median OS values were $20.5{\pm}15.6$ and $11.5{\pm}1.5$ months, respectively (p<0.001). Discussion: As a result, we found that staging with PET CT has better results in terms of survival staging. This superiority leads to survival advantage in patients with locally advanced NSCLC.

Is Sunlight a Predisposing Factor for Triple Negative Breast Cancer in Turkey?

Mutlu, Hasan,Buyukcelik, Abdullah,Colak, Taner,Ozdogan, Mustafa,Erden, Abdulsamet,Aslan, Tuncay,Akca, Zeki Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2

Intraduction: There is known to be a relationship between vitamin D level and more aggresive breast cancer subtypes, especially triple-negative breast cancer (TNBC). It was reported that sunlight exposure has an effect on the prognosis of patients with cancer, possibly related to the conversion of vitamin D to its active form with sunlight. We aimed to evaluate the effect of sunlight exposure on patients with TNBC. Materials-Methods: A total of 1,167 patients with breast cancer from two different regions of Turkey (Antalya and Kayseri, regions having different climate and sunlight exposure intensity over the year) were analysed retrospectively. The ratio of patients with TNBC was identified in those two regions. Results: The ratio of patients with TNBC was 8% and 12% for Kayseri and Antalya regions, respectively, and this difference between the two groups was statistically significant (p=0.021). Discussion: Sunlight exposure may be associated with more prevalent TNBC. This finding should be investigated with a prospective study.

Is Season a Prognostic Factor in Breast Cancer?

Mutlu, Hasan,Akca, Zeki,Cihan, Yasemin Benderli,Kurnaz, Fatih,Aslan, Tuncay,Erden, Abdulsamet,Ugur, Hediye,Aksahin, Arzu,Buyukcelik, Abdullah Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2

Background: Some studies have indicated an inverse relationship between cancer risk and sunlight exposure. Others have reported that the prognosis of some cancers such as prostate, colon, ovarian and non melanoma skin cancer, were affected by the season in which the cancer was diagnosed. In our study, we evaluated whether season is prognostic in Turkish patients with breast cancer. Materials and Methods: A total of 517 patients from Kayseri Training and Research Hospital were analysed retrospectively. Patients were divided into 4 groups according to season of cancer diagnosis: winter, spring, summer and autumn. The prognostic factors for disease free survival and overall survival were investigated. Results: No significant differences were found among groups regarding prognostic factors overall. Only estrogen receptor status and lymphovascular invasion were independent prognostic factors (p=0.001 and p=0.001 respectively). We found significantly differences for mean disease free survival among groups (p=0.019). Winter group had better mean DFS while summer group had worse DFS. Mean overall survival was similar in the four groups (p=0.637). Conclusions: The season is not an independent predictive factor. However, due to interaction with other factors, we think that the season of cancer diagnosis is important for cancer prognosis.