이슬람 연구

El-Khazindar, Fouad Abd El-Salam 한국외국어대학교 1986 한국외국어대학교 논문집 Vol.19 No.1

Could the Breast Prognostic Biomarker Status Change During Disease Progression? An Immunohistochemical Comparison between Primary Tumors and Synchronous Nodal Metastasis

El Nemr Esmail, Reham Shehab,El Farouk Abdel-Salam, Lubna Omer,Abd El Ellah, Mohammed M Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.10

Background: Prognostic biomarkers in breast cancer are routinely investigated in the primary tumors to guide further management. However, it is proposed that the expression may change during the disease progression, and may result in a different immune profile in the metastatic nodes. This work aimed to investigate the expression of breast prognostic biomarkers in primary tumors and in its axillary nodal metastasis, to estimate the possible discordant expression. Materials and Methods: 60 paired primary and axillary nodal metastasis samples were collected from patients with primary breast cancer with positive nodal deposits, diagnosed at the Maadi Military Hospital, Cairo, Egypt, during the year 2013. ER, PR and HER2 expression was assessed by immunohistochemistry in all samples Results: 48.3% of the included cases showed concordant results for both ER and PR receptors between the primary tumor and its nodal metastasis while 51.7% showed discordant results and the discordance level was statistically significant. On the other hand, 70% of the cases showed concordant Her2 results between the primary tumors and the nodal deposits, 30% showed discordant results and the difference was significant. Conclusions: The study indicated that the discordance in ER and PR receptor expression between the primary breast tumor and their nodal metastasis may be significant. The possible switch in the biomarker status during the disease progression is worth noting and may change the patient therapeutic planning. So, whether the treatment selection should be based on biomarkers in the lymph node is a topic for further studies and future clinical trials.

Synthesis and Antibacterial Activity of Azo-Sulfa-Based Disperse Dyes and Their Application in Polyester Printing

Hayam A. Abd El Salam,Mohamed S. Abdel‑Aziz,Eslam Reda El‑Sawy,Elkhabiry Shaban 한국섬유공학회 2023 Fibers and polymers Vol.24 No.8

For conjugating sulfa drug moieties with Schiff’s bases scaffold in the same build through an azo linker to take advantage of the bioactive feature of both motifs, we designed and synthesized a series of bioactive disperse dyes. The target disperse dyes, methyl 2-(E-2-hydroxy-5-((E)-(4-sulfa-derivative) diazenyl)benzylidene) hydrazine-1-carbodithioates 4a–e have been synthesized via the acidic reaction of azo dyes 3a–e with methyl hydrazine carbodithioate. Structures of the synthesized dyes were clarified based on their spectral and elemental analyses. The effectiveness of the dyes was initially tested as an antibacterial toward Staphylococcus aureus ATCC 6538-P and Escherichia coli ATCC 25933. Dyes that were proven to be effective against bacteria have been used as disperse dyes to print polyester fabrics. The color properties of the dyes and their fastness properties counting washing, perspiration, light, rubbing, and sublimation fastness were also examined. The printed polyester fabrics were evaluated for their antibacterial activity via colony-forming unit (CFU) technique. Fabric samples treated with 4c, 4d, and 4b had promising anti-Gram-positive activities against S. aureus. Whereas 4c-, 4d-, and 4b-treated fabrics exhibited moderate anti-Gram-negative activities against the test bacterium E. coli.

The Effects of Moon’s Uneven Mass Distribution on the Critical Inclinations of a Lunar Orbiter

Walid A. Rahoma,Fawzy A. Abd El-Salam 한국우주과학회 2014 Journal of Astronomy and Space Sciences Vol.31 No.4

The uneven mass distribution of the Moon highly perturbs the lunar spacecrafts. This uneven mass distribution leads to peculiar dynamical features of the lunar orbiters. The critical inclination is the value of inclination which keeps the deviation of the argument of pericentre from the initial values to be zero. Considerable investigations have been performed for critical inclination when the gravity field is assumed to be symmetric around the equator, namely for oblate gravity field to which Earth’s satellites are most likely to be subjected. But in the case of a lunar orbiter, the gravity field of mass distribution is rather asymmetric, that is, sectorial, and tesseral, harmonic coefficients are big enough so they can’t be neglected. In the present work, the effects of the first sectorial and tesseral harmonic coefficients in addition to the first zonal harmonic coefficients on the critical inclination of a lunar artificial satellite are investigated. The study is carried out using the Hamiltonian framework. The Hamiltonian of the problem is cconstructed and the short periodic terms are eliminated using Delaunay canonical variables. Considering the above perturbations, numerical simulations for a hypothetical lunar orbiter are presented. Finally, this study reveals that the critical inclination is quite different from the critical inclination of traditional sense and/or even has multiple solutions. Consequently, different families of critical inclination are obtained and analyzed.

Role of nuclear factor-kappa B in bleomycin induced pulmonary fibrosis and the probable alleviating role of ginsenoside: histological, immunohistochemical, and biochemical study

Dalia Refaat El-Bassouny,Nesreen Mostafa Omar,Hanaa Attia Khalaf,Reem Ahmad Abd Al-Salam 대한해부학회 2021 Anatomy & Cell Biology Vol.54 No.4

Bleomycin (BLM) is one of anti-cancerous drugs. One of its limitation is the development of pulmonary fibrosis during therapy So, we proposed to examine the outcome of BLM take on the light and electron microscopic design of rat lung. Along with, assessment the probable protecting role of ginsenoside on BLM induced pulmonary changes. In this study, thirty adult male albino rats were comprised and were classified to four clusters; Negative & positive control group, BLM treated group and BLM& ginsenoside treated group. The lung was treated for histological and immunohistochemical (anti-p65) studies. Light microscopic examination of H&E stained sections of BLM treated group showed huge distortion of the lung building. Mallory trichrome stain of this group showed evident deposition of collagen fibers in the markedly thickened interalveolar septa and around intrapulmonary bronchi, bronchioles and blood vessels. Moreover, strong positive staining for nuclear factor (NF)-κB in the wall of bronchiole as well as the thickened interalveolar septa were observed. Ultrastructural inspection of lung of this group revealed muddled lung planning. Marked improvement of the lung structure and marked reduction in NF-κB immunoexpression was appeared in BLM and ginsenoside treated group. So, we concluded that coadministration of ginsenoside with BLM significantly enhanced the histological and morphometric image of the lung.

The Effects of Moon's Uneven Mass Distribution on the Critical Inclinations of a Lunar Orbiter

Rahoma, Walid A.,Abd El-Salam, Fawzy A. The Korean Space Science Society 2014 Journal of Astronomy and Space Sciences Vol.31 No.4

The uneven mass distribution of the Moon highly perturbs the lunar spacecrafts. This uneven mass distribution leads to peculiar dynamical features of the lunar orbiters. The critical inclination is the value of inclination which keeps the deviation of the argument of pericentre from the initial values to be zero. Considerable investigations have been performed for critical inclination when the gravity field is assumed to be symmetric around the equator, namely for oblate gravity field to which Earth's satellites are most likely to be subjected. But in the case of a lunar orbiter, the gravity field of mass distribution is rather asymmetric, that is, sectorial, and tesseral, harmonic coefficients are big enough so they can't be neglected. In the present work, the effects of the first sectorial and tesseral harmonic coefficients in addition to the first zonal harmonic coefficients on the critical inclination of a lunar artificial satellite are investigated. The study is carried out using the Hamiltonian framework. The Hamiltonian of the problem is cconstructed and the short periodic terms are eliminated using Delaunay canonical variables. Considering the above perturbations, numerical simulations for a hypothetical lunar orbiter are presented. Finally, this study reveals that the critical inclination is quite different from the critical inclination of traditional sense and/or even has multiple solutions. Consequently, different families of critical inclination are obtained and analyzed.

Resonance Capture for a Mercurian Orbiter in the Vicinity of Sun

Khattab, Elamira Hend,El-Salam, Fawzy Ahmed Abd,Rahoma, Walid A. The Korean Space Science Society 2021 Journal of Astronomy and Space Sciences Vol.38 No.2

In this work, the problem of resonance caused by some gravitational potentials due to Mercury and a third body, namely the Sun, together with some non-gravitational perturbations, specifically coronal mass ejections and solar wind in addition to radiation pressure, are investigated. Some simplifying assumptions without loss of accuracy are employed. The considered force model is constructed. Then the Delaunay canonical set is introduced. The Hamiltonian of the problem is obtained then it is expressed in terms of the Deluanay canonical set. The Hamiltonian is re-ordered to adopt it to the perturbation technique used to solve the problem. The Lie transform method is surveyed. The Hamiltonian is doubly averaged. The resonance capture is investigated. Finally, some numerical simulations are illustrated and are analyzed. Many resonant inclinations are revealed.

Resonance Capture for a Mercurian Orbiter in the Vicinity of Sun

Khattab, Elamira Hend,El-Salam, Fawzy Ahmed Abd,Rahoma, Walid A. The Korean Space Science Society 2021 Journal of astronomy and space sciences Vol.38 No.2

In this work, the problem of resonance caused by some gravitational potentials due to Mercury and a third body, namely the Sun, together with some non-gravitational perturbations, specifically coronal mass ejections and solar wind in addition to radiation pressure, are investigated. Some simplifying assumptions without loss of accuracy are employed. The considered force model is constructed. Then the Delaunay canonical set is introduced. The Hamiltonian of the problem is obtained then it is expressed in terms of the Deluanay canonical set. The Hamiltonian is re-ordered to adopt it to the perturbation technique used to solve the problem. The Lie transform method is surveyed. The Hamiltonian is doubly averaged. The resonance capture is investigated. Finally, some numerical simulations are illustrated and are analyzed. Many resonant inclinations are revealed.

Fabrication and characterization of dual-band organic/inorganic photodetector for optoelectronic applications

H. Abdel-Khalek,Mohamed Abd- El Salam,Fatma M. Amin 한국물리학회 2019 Current Applied Physics Vol.19 No.4

In this work, the optoelectronic performance of organic/inorganic heterojunction photodiode based on alphasexithiophene (α-6T/n-Si) is introduced. A thin film of α-6T was deposited on the n-type silicon substrate by a thermal evaporation technique. The topographical properties of the α-6T thin film grown on the n-Si substrate were investigated using a field emission scanning electron microscope (FESEM) technique. A network of nanocrystalline needles over the film surface was observed which give rise to an improvement in the electric charge transport. The optical properties of the prepared thin film were investigated using a spectrophotometric technique. The high absorption of α-6T in UV and visible region suggested the ability of this architecture for UV and visible light detection. The I-V characteristics of the fabricated photodiode were investigated in dark and under different illumination intensities and different wavelengths. The present architecture showed a good response to halogen lamb light, where the estimated values of rising and falling time at 160 mW/cm2 were about 400 ms and 450 ms, respectively. The results show the possibility of using Au/α-6T/n-Si/Al structure as a photodetector for a wide range of the solar spectrum (UV–Visible).

Fabrication and performance evaluation of ultraviolet photodetector based on organic /inorganic heterojunction

H. Abdel-Khalek,M.I. El-Samahi,Mohamed Abd- El Salam,Ahmed M. El-Mahalawy 한국물리학회 2018 Current Applied Physics Vol.18 No.12

Organic/inorganic ultraviolet photodetector was fabricated using thermal evaporation technique. Organic/inorganic heterojunction based on thermally evaporated copper (II) acetylacetonate thin film of thickness 200 nm deposited on an n-type silicon substrate is introduced. I–V characteristics of the fabricated heterojunction were investigated under UV illumination of intensity 65 mW/cm2. The diode parameters such as ideality factor, n, barrier height, ΦB, and reverse saturation current, Is, were determined using thermionic emission theory. The series resistance of the fabricated diode was determined using modified Nord's method. The estimated values of series resistance and barrier height of the diode were about 0.33 KΩ and 0.72 eV, respectively. The fabricated photodetector exhibited a responsivity and specific detectivity about 9 mA/W and 4.6×109 Jones, respectively. The response behavior of the fabricated photodetector was analyzed through ON-OFF switching behavior. The estimated values of rise and fall time of the present architecture under UV illumination were about 199 ms and 154 ms, respectively. Finally, enhancing the photoresponsivity of the fabricated photodetector, post-deposition plasma treatment process was employed. A remarkable modification of the device performance was noticed as a result of plasma treatment. These modifications are representative in a decrease of series resistance and an increase of photoresponsivity and specific detectivity. The process of plasma treatment achieved an increment of external quantum efficiency from 5.53% to 8.34% at −3.5 V under UV illumination.