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RISS 인기검색어
- 검색키워드
- 저자 : Abd El-Fatah Abomohra (검색결과 2 건)
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Protective effect of Arthrospira platensis against liver injury induced by copper nanoparticles
Reham Ebaid,Abd El-Fatah Abomohra,Elhussainy Elhussainy,Safinaz El-Shourbagy,Sameh Ali 경희대학교 융합한의과학연구소 2017 Oriental Pharmacy and Experimental Medicine Vol.17 No.3
Although copper oxide nanoparticles (nano-CuO) are one of widely used engineered nanoparticles, their human and animal exposure led to particular structural changes in tissues and organs. The present study was undertaken to examine the protective effects of the blue-green microalga Arthrospira platensis against nano-CuO-induced hepatotoxicity in albino rats. Results showed that nano-CuO injection led to significant reduction in serum albumin level with a significant increase in alanine transaminases (ALT) and aspartate transaminases (AST) activities after 24 h of administration. In addition, nano-CuO administration resulted in significant increase in malondialdehyde (MDA) level and catalase (CAT) activity, with a significant reduction in reduced glutathione (GSH) level. Administration of A. platensis alone did not significantly alter the normal levels of aminotransferase enzymes, antioxidants or oxidative stress marker. However, pretreatment with A. platensis prior to nano-CuO intoxication attenuated the levels of ALT, AST (liver function markers) and MDA (lipid peroxidation marker). It also normalized the levels of both hepatic enzymatic and non-enzymatic antioxidants (CAT and GSH, respectively). In conclusion, the present study confirmed the hepatotoxicity of nano-CuO at 10 mg kg−1 administration dose. However, administration of A. platensis could represent a significant protective mechanism against hepatotoxicity.
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Ha, Geon-Soo,El-Dalatony, Marwa M.,Kim, Do-Hyeon,Salama, El-Sayed,Kurade, Mayur B.,Roh, Hyun-Seog,El-Fatah Abomohra, Abd,Jeon, Byong-Hun Elsevier 2020 Bioresource technology Vol.302 No.-
<P><B>Abstract</B></P> <P>Microalgal cell wall integrity and composition have a significant impact on the fermentation process and biofuel recovery. In this study, various biofuels (bioethanol, higher alcohols (C3-C5), and biodiesel) were produced by the fermentation of carbohydrates and proteins, and transesterification of lipids from three different microalgal strains (<I>Pseudochlorella</I> sp., <I>Chlamydomonas mexicana</I>, and <I>Chlamydomonas pitschmannii</I>), each possessing different proportions of bioconstituents (carbohydrates, proteins, and lipids). Changes in the cell wall structure and thickness were observed before and after fermentation using transmission electron microscopy. <I>Pseudochlorella</I> sp. showed the highest yields of bioethanol (0.45 g-ethanol/g-carbohydrates), higher alcohols (0.44 g-higher alcohols/g-proteins), and biodiesel (0.55 g-biodiesel/g-lipids), which consequently revealed a maximum energy recovery (42%) from whole constituents. This study suggests that different physiological properties, including cell wall thickness and the proportion of bioconstituents in microalgae, could have a significant impact on the pretreatment and fermentation efficiencies for biofuels production.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Algal biocomponents has an influence on pretreatment and fermentation efficiency. </LI> <LI> Highest biofuels yield (0.44–0.55 g/g) was obtained from <I>Pseudochlorella</I> sp. </LI> <LI> Cell wall thickness dependent on bioconstituents and affected biofuels yield. </LI> <LI> Highest total energy recovery (42%) was achieved using suitable <I>Pseudochlorella</I> sp. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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