HIV감염과 MICA (MHC class I chain-related A) 대립 유전자의 연관성

강문원,위성헌,김양리,이주실,표철우,한훈,김태규,Kang, Moon-Won,Wie, Seong-Heon,Kim, Yang-Ree,Lee, Joo-Shil,Pyo, Chul-Woo,Han, Hoon,Kim, Tai-Gyu 대한면역학회 2001 Immune Network Vol.1 No.2

Background: A large number of diseases occur in association with specific HLA-B or-C alleles. Recently a new gene, termed maj or histocompatibility complex class I chain-related gene A (MICA), has been identified in close proximity to HLA-B. The function of this gene is still unknown. However, it is structurally similar to HLA class I genes. MICA gene is polymorphic and is potentially associated with several diseases. Methods: To evaluate the association of MICA gene in Korean patients with human immunodeficiency virus 1 (HIV-1) infections, Polymerase chain reaction-Sequence specific primer (PCR-SSP) was done for MICA alleles in the extracellular exons, and a microsatellite analysis for GCT repeat polymorphisms in the TM exon was also completed. Results: In 199 Korean healthy controls, 7 alleles were observed and the frequencies for each allele were MICA008 (44.7%), MICA0 10 (34.2%), MICA002 (31.7%), MICA004 (23.6%), MICA0 12 (2 1.6%), MICA009 (19.6%), and MICA007 (6.5%). When 65 HIV seropositive patients were analyzed, MICA007 allele frequency was significantly higher than in controls (15.4% vs 6.5 %, RR=2.6, p<0.04). In contrast, the frequencies of other MICA alleles and microsatellite alleles in the transmembrane region of MICA gene were not significantly different between HIV seropositive patients and controls. The tight linkage between MICA alleles in the extracellular exons and GCT repeat polymorphisms in the TM exon was observed as follows; MICA002/A9, MICA004/A6, MICA007/A4, MICA008/A5.1, MICA0 10/A5, and MICA0 12/A4 in both groups. No significant difference between patients and controls was observed in the haplotype frequencies of MICA alleles in the extracellular exons and GCT repeat polymorphisms in the TM exon. Conclusion: The data suggest that immune functions related with MICA gene may affect a HIV infections.

무사상(無思想)이라는 일본 사회사상의 전통과 그 현대적 전개

강문원 ( Kang Moon-won ),류영진 ( Ryu Young-jin ) 동양사회사상학회 2014 사회사상과 문화 Vol.29 No.-

흔히 일본의 사회사상의 특징을 무사상의 사상이라고 한다. 본고에서는 이 무사상의 사상이라고 하는 일본 사회사상의 전통을 세 가지 범주로 나누어 정리하여 본다. 그 전통의 배경에는 일본의 종교. 신도가 있다고 하는 종교적 해석, 이 전통은 일본의 지정학적 조건에서 비롯된 것이라고 하는 지정학적 해석, 그리고 무사상은 일본인의 일상적 효용을 높이는 편리한 사고수단으로써 일본인의 현세주의에서 비롯된 것이라고 해석하는 경제학적 해석의 세 가지 범주이다. 일본의 지식인들 중에는, 사상은 인간을 행복하게 하는 것이어야 하며 사회사상은 현실의 변화에 따라 쉽게 변하는 것이라고 하는 주장을 하는 이들도 있는데 이러한 주장도 무사상의 전통과 무관하지 않다는 것을 본고는 설명한다. 또한 본고에서는 1980년대 이후 일본 사회에 커다란 영향을 끼친 포스트모더니즘, 현재 많은 사람들의 관심의 대상이기도 한 ‘넷우익’, 그리고 넷우익을 접하는 일본 지식인의 태도도 위와 같은 일본의 사상적 전통 위에서 설명할 수 있다는 의견을 제시한다. The Japanese philosophy is often described by the term of no(or zero) philosophy. This study discerns three distinct sources of this zero-philosophy tradition. Firstly, there is a view that this tradition is rooted in Japanese religion Shindo, secondly, some Contend that this tradition is related with geographical position of Japan sited afar from China or USA. Thirdly, there are arguments in Japan that this tradition is rational result of Japanese realism, according to which a social philosophy must serve for the welfare and happiness of people. In their arguments and explanations of the post-modernism in Japan, the writings and activities of so-called Internet Right Wings, some Japanese scholars implicitly assume and show attitudes that a social philosophy is, or must be, something which can be easily changed and something which can enhance the happiness of people. In these respects, it seems that Japanese tradition of zero-philosophy plays a strong role in modern day lives of the Japanese.

AIDS와 결핵

강문원 ( Moon Won Kang ) 대한결핵 및 호흡기학회 1991 Tuberculosis and Respiratory Diseases Vol.38 No.3

차량 거동에 따른 브레이크 호스 형상 변형 예측 연구

강문원(MOON-WON KANG),이원재(WON-JAE LEE),전성진(SUNG-JIN JEON) 한국자동차공학회 2011 한국자동차공학회 부문종합 학술대회 Vol.2011 No.5

This paper presents the study on predicting brake hose deformation during the movement of vehicle. A process that links CATIA template with deformation analysis is proposed and a beam model that has section modulus is used for analysis. A Program is developed for simple use of the process in the design phase where the layout is frequently changing. The usability of the process is proved by comparing measurement data of 3D hose installed in the vehicle with the analysis result.

각종 질환에 있어서 복수 흉수 및 뇌척수액의 Ph , PO2 , PCO2 에 관한 연구

최영길 ( Young Kil Choi ),강문원 ( Moon Won Kang ),김재형 ( Jae Hyung Kim ),김훈교 ( Hoon Kyo Kim ) 대한내과학회 1977 대한내과학회지 Vol.20 No.3

신장이식환자 소변에서 중합효소연쇄반응 및 교잡법을 이용한 인형거대세포바이러스(Human Cytomegalovirus)의 조기 진단

김태규(Tai-Gyu Kim),강문원(Moon-Won Kang),신완식(Wan-Shik Shin),유문간(Mun-Gan Rhyu),정연준(Yeun-Jun Jung),한훈(Hoon Han),김금용(Gum-Ryong Kim) 大韓微生物學會 1992 大韓微生物學會誌 Vol.27 No.1

Klebsiella pneumoniae 표준균주에 대한 Ceftriaxone과 Amikacin의 단독 및 병용요법의 Postantibiotic Effect

이동건,허동호,최정현,유진홍,강문원,신완식,Lee, Dong-Gun,Huh, Dong-Ho,Choi, Jung-Hyun,Yoo, Jin-Hong,Kang, Moon-Won,Shin, Wan-Shik 대한임상약리학회 1999 臨床藥理學會誌 Vol.7 No.1

연구배경 및 방법 : PAE는 세균을 항생제에 제한된 시간 동안 노출시키고 항생제를 제거한 후에도 세균의 성장은 계속 억제되는 현상을 말하며 항생제의 효과는 항생제가 제거된 후에도 일정기간동안 유지되는 것으로 항생제 투여횟수, 시기 등을 결정하는데 중요한 요소로 알려져 있다. 그러나, 항생제와 균의 종류, 농도, 실험조건 둥에 따라 PAE가 다르고 그 길이가 측정하는 방법에 따라 많은 차이가 있다. 특히, 그람음성균에 ${\beta}$-lactam 항생제에 노출되었을 때의 PAE는 정도의 차이가 아닌 그 존재의 유무에 대해서조차 논란이 있는 실정이다. 또한, 그람음성균에 ${\beta}$-lactam과 aminoglycoside를 병용할 때 PAE가 상승작용이 있는지에 대해서도 논란이 있다. 저자들은 K. pneumoniae를 대상으로 ceftriaxone과 amikacin을 병용하였을 때 PAE가 있는지 알아보기 위하여 전통적인 집락수 측정법과 BACTEC 혈액배양법을 사용하고 이를 비교하였고 병용시 상승작용이 있는지 알아보았다. 결 과: (1) K. pneumoniae에 대한 ceftriaxone과 amikacin의 상승작용을 disk diffusion 방법, checkerboard 방법, time-kill curve 및 E-test 등을 이용하여 확인한 결과 무작용의 상관관계를 보였다. (2) 1배 MIC $(0.03\;{\mu}/mL)$의 ceftriaxone에서 집락 수 측정법으로 측정한 PAE는 -0.4시간이었으나, 4배 MIC $(4\;{\mu}/mL)$의 amikacin에서는 2.7시간의 PAE를 나타냈다. (3) 다양한 농도의 ciprofloxacin에 2시간 동안 노출시킨후 집락수 (y)와 BACTEC 혈액배양기의 GV (x)는 log y=0.0514x+4의 관계가 있었으며(r=0.88, p<0.0001), 이를 이용해 ceftriaxone의 PAE를 보정한 결과 0시간으로 정정되었다. (4) ceftriaxone과 amikacin을 병용하였을때 집락수 측정법에 의한 PAE는 3.4시간으로 상가작용을 보였다. 결 론: (1) BACTEC 혈액배양법을 이용한 PAE의 측정결과 K. pneumoniae에 대한 ceftriaxone의 PAE는 집락수 측정법에 의해 과소평가 되어있음이 확인되었고 실제적으로는 PAE를 나타내지 않았다. (2) ceftriaxone이 PAE가 없는 이유는 filament를 형성하기 때문이 아니고 본래 PAE가 없는 것으로 추론된다. Introduction & Methods : The postantibiotic effect (PAE) refers to a suppression of bacterial growth that persists after limited exposure of organisms to antimicrobial agents. The major clinical relevance of the PAE pertains to its impact on antimicrobial dose and dosing interval. There is a method-to-method variation in determination of PAE. In case of Gram negative organisms, ${\beta}$-lactams do not demonstrate PAE on the basis of viable count method, a conventional standard. However, as several Gram negative organisms aggregate to form a filament after exposure to ${\beta}$-lactams, the number of colony may not be precisely counted. To overcome this problem, we also used another indicator of assessing PAE-i.e., growth value which represents $CO_2$ generation from colony. In this study, PAE of ceftriaxone alone and in combination with amikacin were determined for the standard strain of K. pneumoniae using viable counting method and BACTEC blood culture system. Results : (1) Using the disk diffusion method, the checkerboard method, the time kill method and the E-test, we could not find synergistic effects with ceftriaxone and amikacin against K. pneumoniae. (2) On the basis of the viable counting method, PAE of ceftriaxone $({\times}1\;MIC,\;0.03\;{\mu}g/mL)$ was negative (-0.4 hours) and that of amikacin $({\times}4\;MIC,\;4\;{\mu}g/mL)$ was 2.7 hours. (3) Following 2-hour exposure to ciprofloxacin at various concentration, the correlation between the cell count (y) and GV (x) measured by BACTEC blood culture system was significantly high (log y=0.0514x+4, r=0.88, p<0.0001). Although recalculating the PAE of ceftriaxone using the above curve, the subsequently corrected PAE value was 0 hour. (4) The ceftriaxone-amikacin combination caused additive effect for PAE against K. pneumoniae compared with the PAE observed after ceftriaxone or amikacin alone measured by the viable counting method. Discussion : (1) Although it is evident that the viable count method underestimated the PAE of ${\beta}$-lactams agianst K. pneumoniae, PAE was absent in spite of correction by BACTEC blood culture system. (2) It may be possible the ceftriaxone does show no PAE against K. pneumoniae naturally not because of filament formation.

3` , 4` - Dideoxykanamycin B 의 임상효과

정희영 ( Hee Young Chung ),정규원 ( Kyu Won Chung ),강성구 ( Sung Koo Kang ),강문원 ( Moon Won Kang ),최규용 ( Kyu Yong Choi ) 대한내과학회 1976 대한내과학회지 Vol.19 No.4

증례 : 원인불명의 Fragmentation Hemolytic Anemia 1 예

김기호 ( Ki Ho Kim ),홍순조 ( Soon Jo Hong ),김선무 ( Sun Moo Kim ),강문원 ( Moon Won Kang ),김영우 ( Young Woo Kim ),노재철 ( Jae Chull Rho ) 대한내과학회 1977 대한내과학회지 Vol.20 No.1

APACHE 3 를 이용한 내과 중환자실 환자의 질병 중증도 평가

유진홍(Jin Hong Yoo),김연근(Yeon Keun Kim),신완식(Wan Shik Shin),강문원(Moon Won Kang) 대한내과학회 1996 대한내과학회지 Vol.50 No.3

N/A Objectives : In order to quantify the risk for medical intensive care unit (ICU) patients and to establish the guideline for decision making by using Acute Physiology and Chronic Health Evaluation (APACHE) III score. Methods : Total 204 medical ICU patients from July-1993 to September-1993 were enrolled to this study. Patients were categorized into subgroups by major disease cateogories, We measured acute physiologic variables, age, comorbidities, and chronic health status according to the APACHE III scoring system. Logistic regression analysis was done to determine the relationship between APACHE III score and death risk. Results : The overall mortality rate of 204 medical ICU patients was 28.4% (58/204). The majority of patients showed standard distribution over 17~72 APACHE III points. The main APACHE III point of survived group(n=146) was significantly lower than that of non-survived group(n=58), 43.6 vs 69.4, respectively(p<0.01). Logistic regression analysis about the relationship between APACHE III score and death risk gave the equation like this: logn R/1-R= 0.04314×(APACHE III)-3.488 According to this equation, the estimated risk of death was over 50% at the point range of 80~85 and over 90% at 130~135. Conclusion: APACHE IU scoring system could be a useful guideline to predict and to evaluate the outcome in medical ICU patients and it would aid us in clinical decision making and proper management of ICU patients.