R을 활용한 서비스마케팅 연구동향 분석

주전전(Tian-Tian Zhou),김병대(Byung-Dae Kim) 한국콘텐츠학회 2023 한국콘텐츠학회논문지 Vol.23 No.3

본 연구는 최근 5년간 서비스마케팅에 관한 연구 주제어를 분석하고, 주요 이슈들과 향후 연구 과제를 도출하기 위해 연구동향을 파악하여 정량분석을 시행하였다. 본 연구의 분석은 각 논문별 키워드에서 R을 활용한 워드클라우드 분석방법을 적용하여 서비스마케팅 연구 동향을 파악하고자 한다. 이를 위해 2017년~2021년간 최근 5년간의 KCI 등재 및 등재후보 연구를 분석하였다. 최근 5년 동안 코로나19를 기준으로 2017년~2019년과 2020년~2021년으로 나눠 분석하였다. 분석결과는 2017년~2019년과 2020년~2021년 연구 주제어의 이슈 차이가 나타났다. 2017년~2019년에서 3년간 SNS가 가장 높은 빈도를 보이며, 마케팅믹스, 내부마케팅, 체험마케팅, 고객만족, 마케팅, SNS마케팅 등의 순으로 나타났다. 2020년~2021년 2년간 내부마케팅은 가장 높은 빈도를 보였으며, 고객만족, 마케팅, 서비스마케팅, 관계마케팅, 서비스품질, 코로나19, SNS 등의 순으로 나타났다. 5년간 서비스마케팅에 대한 연구들은 SNS, 내부마케팅, 고객만족, 마케팅, 마케팅믹스, 서비스마케팅, 서비스품질 등의 이슈가 높은 것으로 나타났다. 국내 서비스마케팅연구 주제들은 몇몇 주제에 고착화되어 있지 않고 빠르고 다양하게 변화하고 있다. 이에 따라 SNS나 내부마케팅과 같은 연구의 주제가 지속적으로 등장하고 있는 것으로 확인된다. 본 연구는 서비스마케팅의 최근 5년간의 연구동향을 파악하고 향후연구를 위한 현안들을 제공한다는 점에서 그 의의를 찾을 수 있다. In this study, research keywords related to service marketing for the last 5 years were analyzed, research trends were identified and quantitative analysis was performed to derive major issues and future research tasks. This study analyses the trend of service marketing research by applying the word cloud analysis method using R to the keywords of each paper. To this end, The data were analyzed by dividing the three-year period from 2017 to 2019, the two-year period from 2020 to 2021, and the five-year research trend. As for the analysis results, there was a significant difference between the keywords of the studies from 2017 to 2019 and 2020 to 2021, but the research issues differed. SNS showed the highest frequency for 3 years, followed by the marketing mix, internal marketing, experiential marketing, customer satisfaction, marketing, and SNS marketing. Internal marketing showed the highest frequency for two years, followed by customer satisfaction, marketing, service marketing, relationship marketing, service quality, COVID-19, and SNS. Over the past 5 years, researchers on service marketing showed a lot of interest in issues such as SNS, internal marketing, customer satisfaction, marketing, marketing mix, service marketing, and service quality. Domestic service marketing research topics are not fixed to a few topics but are changing rapidly and diversely. Accordingly, it is confirmed that research topics such as SNS and internal marketing are continuously appearing. The significance of this study can be found in that it identifies research trends in service marketing for the last 5 years and provides current issues for future research.

황흑산(黃黑散)의 메티실린 내성 황색포도상구균에 대한 항균 활성과 옥사실린과의 시너지 효과

최성훈 ( Sung-hoon Choi ),강옥화 ( Ok-hua Kang ),주전 ( Tian Zhou ),공룡 ( Ryong Kong ),이승진 ( Seung-jin Lee ),강담희 ( Dam-hee Kang ),정혜인 ( Hye-in Jung ),이영섭 ( Young-seob Lee ),권동렬 ( Dong-yeul Kwon ) 대한본초학회 2016 大韓本草學會誌 Vol.31 No.5

Objectives : Hwangheuk-san is a complex prescription composed of oriental traditional medicine and has been reported for antioxidant, antimicrobial and anticancer effects in the recent study. Methicillin-resistant Staphylococcus aureus (MRSA) is one of important causes of fatal infectious diseases such as septicemia, endocarditis, toxic shock syndrome, pneumonia, skin and soft tissue infections (SSTIs). S. aureus is reported as being for a variety of human diseases and its epidemiological relevance is mainly due to their ability of becoming highly resistant to common antimicrobials such as tetracycline, penicillin, cphalosporin and aminoglycoside. The objective of this study is to determine the antimicrobial effect of Hwangheuk-san ethanol extracts (HHS) and synergistic effects with antibiotics oxacillin against MRSA. Methods : The antimicrobial activity of HHS was measured by the disc diffusion method, broth microdilution method and the checkerboard dilution test, time-kill curve assay was performed to investigate synergistic effects with antibiotics oxacillin against MRSA. Results : HHS showed antimicrobial activity against MRSA with a MIC value of 125 ㎍/㎖. In the checkerboard test, the interaction of HHS with antibiotics oxacillin produced almost synergy or partial synergy against MRSA. This study showed that HHS reduced the MICs of oxacillin tested, and a remarkable antibacterial effect of HHS, with membrane permeability enhancers. Conclusions : These results suggest that HHS has the antimicrobial effect and synergistic effects with antibiotics oxacillin against MRSA. This study thus can be a valuable source for the development of a new drug with low MRSA resistance.

현토단(玄兎丹)의 RAW 264.7 대식 세포에서의 항염증 효과에 관한 연구

김마룡 ( Ma-ryong Kim ),강옥화 ( Ok-hua Kang ),공룡 ( Ryong Kong ),서윤수 ( Yun-soo Seo ),주전 ( Tian Zhou ),김상아 ( Sang-a Kim ),김은수 ( Eun-su Kim ),신민아 ( Min-a Sin ),이영섭 ( Young-seob Lee ),권동렬 ( Dong-yeul Kwon ) 대한본초학회 2017 大韓本草學會誌 Vol.32 No.2

Objectives : This study aimed to investigate the unknown mechanisms behind the anti- inflammatory activity of Hyeonto-dan (HT) 70% ethanol extract on LPS-stimulated RAW 264.7 cells. Methods : Cells were treated with Hyeonto-dan 1 h prior to addition of 200 ng/mL of LPS. Cell viability was measured by the MTS assay. Nitric oxide levels were determined by the Griess assay. PGE2 were measured using EIA kit. Proinflammatory cytokine production was measured by the enzyme-linked immunosorbent assay (ELISA). The expression of COX-2, iNOS, and MAPKs was investigated by Western blot, qRT-PCR. NF-κB/p65 localization and interaction of the TLR-4 receptor with LPS was examined by immunofluorescence assays. Results : Hyeonto-dan had no cytotoxicity at the measured concentration. Hyeonto-dan inhibited NO production and pro-inflammatory cytokines such as IL-6, TNF-α, and PGE2 as well as the protein and mRNA expression of iNOS and COX-2. Moreover, Hyeonto-dan inhibited the interaction between LPS and TLR-4 in murine macrophages. It suppressed phosphorylation of extracellular signal-regulated kinase (ERK 1/2), c-jun N-terminal kinase (JNK 1/2) and p38. Finally, it inhibited translocation of NF-κB in response to competitive LPS. Conclusions : Based on the results of this study, Hyeonto-dan inhibited the binding of TLR-4 receptor to LPS and inhibited the phosphorylation of extracellular signaling pathway MAPKs. These inhibitory effects are thought that the amount of NF-κB delivered to the nucleus was decreased and the inflammatory reaction was prevented by decreasing the production of LPS-induced PGE2,NO, IL-6 and TNF-α

대황고(大黃膏)의 메티실린 내성 황색 포도상구균에 대한 항균활성

이순애 ( Sun-ae Lee ),공룡 ( Ryong Kong ),강옥화 ( Ok-hua Kang ),서윤수 ( Yun-soo Seo ),주전 ( Tian Zhou ),김상아 ( Sang-a Kim ),송옥희 ( Ok-hee Song ),김민철 ( Min-chul Kim ),한형선 ( Hyoung-sun Han ),최지나 ( Ji-na Choi ),이영섭 대한본초학회 2017 大韓本草學會誌 Vol.32 No.2

Objectives : Infectious diseases by Methicillin-Resistant Staphylococcus aureus (MRSA) are a growing problem worldwide. Characteristic of MRSA is endlessly mutation to resist antibiotics. Daehwanggo (DHG) is one of the oriental medicine prescriptions contained in Principles and Practice of Eastern Medicine. Daehwanggo was mainly used for external preparation from old times. The purpose of this study is to confirm possibility as supplementary drug of DHG about antibiotics through observation of synergy effect between DHG and commercial antibiotics and to observe restriction on growth of MRSA on any pathway through observation of mechanism. Methods : The minimum inhibitory concentration (MIC) of DHG against MRSA is 500 ~ 2000 ㎍/㎖ by broth dilution method. In the checkerboard method, the combinations of DHG with antibiotics has partial synergistic effect or synergy effect and DHG markedly reduced the MICs of the antibiotics oxacillin (OX), gentamicin (GT) against MRSA. In the inhibition of resistance mechanism of DHG against MRSA, the expression of resistance gene and protein about β-lactam antibiotic was reduced. Also, we observed the effect of DHG about cell membrane permeability against MRSA, and confirmed that DHG suppressed growth of strains by increasing cell membrane permeability. Results : Basis on the result, we speculate that DHG increase antibacterial activity of antibiotics against MRSA by changing the structure of cell wall of MRSA. Conclusions : These data suggest that Daehwanggo possesses possibility as supplementary drug about antibiotics against MRSA.