Significant roles of neuroinflammation in Parkinson’s disease: therapeutic targets for PD prevention

이유정,Seulah Lee,장승철,Jaewon Lee 대한약학회 2019 Archives of Pharmacal Research Vol.42 No.5

Glial cells outnumber neurons in the brain and play important roles in the neuroinflammation that accompanies brain damage in neurodegenerative diseases. In Parkinson’s disease (PD), dopaminergic neuronal loss is accompanied by inflammatory changes in microglia, astrocytes, innate immune cells, and infiltrating peripheral immune cells. Neuroinflammation is probably a fundamental immune response to protect neurons from harm and compensate for neuronal damage, but at the same time, its neurotoxic effects exacerbate neuron damage. Furthermore, neuroinflammatory response is regulated by immune cells, such as microglia, astrocytes, and peripheral immune cells, and by cytokines and chemokines. Accordingly, it is crucial that we understand how such immune cells in the brain regulate neuroinflammatory responses in PD pathology. This review describes the roles played by glia-mediated neuroinflammation in PD, both good and bad, and the therapeutic strategies used to treat PD.

호머 헐버트의 한국 민속연구와 영역 설화집으로서의 『THE KOREA REVIEW』

이유정 ( Yu Jung¸ Lee ) 국제비교한국학회 2021 비교한국학 Comparative Korean Studies Vol.29 No.2

이 논문의 목적은 근대 초기 교육학, 역사학, 언어학 등 다양한 분야의 한국 연구에 기여한 것으로 평가되는 호머 헐버트(Homer B. Hulbert)가 발간했던 영문 잡지 The Korea Review를 영역(英譯) 설화집 연구의 주요 자료로 살펴보며, 이 잡지에 수록된 한국 설화 목록을 작성하여 소개하는 것이다. 근대 초기 서양인들에 의해 영역된 한국의 고소설, 설화를 중심으로 진행된 최근 연구들은 단행본으로 출판된 영역 설화집을 중심으로 이루어져 온 경향이 있다. 이 논문에서는 위의 선행 연구들에서 미처 다루지 못한 근대 잡지, 특히 The Korea Review를 통해 소개되었던 영역 한국 설화의 목록을 작성하여 소개하고자 한다. 이 잡지는 Hulbert의 주도적인 편집으로 한국 감리교 출판부(Methodist Publishing House)에서 1901년부터 1906년까지 발행되었으며, 이 잡지에 소개된 설화의 상당 부분이 Hulbert에 의해 수집, 채록, 영역된 것으로 확인된다. 정기 간행물로서 매달 고정적으로 작품이 소개되고 있기 때문에 이야기의 수와 다양성에 있어서는 개화기부터 일제 식민시기에 영역된 어떤 설화집보다도 다수의 목록을 포함하고 있는 것을 확인할 수 있다. The Korea Review에 수록된 설화들의 목록을 정리하기에 앞서, 본문 1장에서는 The Korea Review의 전체적인 구성, 창간 경위, 목적, 주요 필자, 독자층, 편집 의도 등에 대해 살펴보고, 2장에서는 Hulbert의 민속학 연구에 대한 시각과 설화 수집 방법에 대하여 검토한다. 그리고 마지막으로 3장에서는 The Korea Review에 수록된 설화 목록을 작성하여 향후 영역 설화 연구의 주요 텍스트로 활용될 수 있도록 하였다. The purpose of this paper is to examine The Korea Review, an English magazine published from 1901 to 1906 in the early modern Korea by Homer B. Hulbert. He is considered to have contributed to Korean Studies in the various fields such as education, history, and linguistics; however, this paper pays more attentions to him as a folklorist or a collector of Korean folktales. In doing so, it aims to introduce the list of Korean folktales included in this magazine. Recently, many scholars have studied Korean folktales collected and translated by foreigners during the early modern Korea, including the collections of Horace Allen and James Gales, but they have not dealt with the collections of folktales in The Korea Review. In the first section of this paper, I explore the overall structure of the magazine, focusing on its founding process, purpose, and readership, content composition, and editorial intent. In the second section, I will review Hulbert’s perspectives on folklore studies and the method of collecting stories of the time. Finally in the third section, I will introduce the list of folktales in the magazine.

항암제 (5-fluorouracil, doxorubicin, vincristine)로 인한 비장세포의 면역억제에 대한 Bordetella bronchiseptica의 보호 효과

이유정,주홍구,Lee, You-Jeong,Joo, Hong-Gu 대한수의학회 2022 大韓獸醫學會誌 Vol.62 No.3

5-Fluorouracil, doxorubicin, and vincristine are chemotherapy agents used to treat various cancers, such as breast cancer and lymphoma for decades, and their effects on cancer have been proven. On the other hand, these anti-cancer drugs cause fatal side effects, including immunosuppression. This study investigated whether sonicated Bordetella bronchiseptica bacterin (B. bronchiseptica) can attenuate the immunosuppression of spleen cells induced by these chemotherapy agents and which subsets of spleen cells were affected. B. bronchiseptica increased the metabolic activity of spleen cells treated with 3 anti-cancer drugs. Cell death analysis using Annexin V/propidium iodide showed that B. bronchiseptica markedly decreased the death of spleen cells. The subsets of spleen cells were analyzed by flow cytometry using a surface marker-specific antibody. B. bronchiseptica increased nitric oxide production in the spleen cells treated with anti-cancer drugs (p < 0.0001). Despite the pharmacological effects of anti-cancer drugs, many patients suffer from the fatal side effects of immunosuppression. This study provides valuable information on how to overcome chemotherapy-induced immunosuppression.

마우스 수지상세포의 항원 제시 능력에 대한 이온화 규소수의 biphasic 면역조절 효과

이유정,주홍구,Lee, You-Jeong,Joo, Hong-Gu 대한수의학회 2021 大韓獸醫學會誌 Vol.61 No.2

Biosilica is a silica-based substance derived from the cell walls (frustules) of diatoms. Recently, research into biosilica's biological functions is underway, but little has been reported on the effects of biosilica on immune cells. In this study, we investigated the effect of ionized biosilica water (iBW) on dendritic cells (DCs), which play crucial roles as antigen (Ag)-presenting cells. Treatment with iBW increased the expression of immune response-related markers, closely connected to the maturation of DCs, and the production of tumor necrosis factor-alpha. In addition, iBW-treated DCs (iBW-DCs) had a lower uptake of fluorescein isothiocyanate-dextran than that of control DCs. Mixed leukocyte response analysis used for measuring the Ag-presenting capability of DCs, showed iBW-DCs had a higher capability than that of control DCs. Interestingly, DCs treated with lipopolysaccharide (LPS) and iBW had a lower level of Ag-presenting capability than that of LPS-treated DCs. Taken together, the results indicate that iBW alone can mature DCs, but it decreases the Ag-presenting capability of DCs in the presence of LPS, a representative agent of inflammation. This study may provide valuable information regarding the effect of iBW on immune cells. Further research is needed to investigate how iBW induces the observed biphasic immunomodulatory activity.

OptSim Overview: The system and Network Software for Telecommunication Engineering

이유정,Lee, Yu-Jeong 한국광학회 2007 광학과 기술 Vol.11 No.1

서낙동강에서 동·식물플랑크톤의 총유기탄소 기여율 변동 분석

이유정,Lee, You-Jung 한국환경과학회 2020 한국환경과학회지 Vol.29 No.7

Carbon biomass of plankton community, Total Organic Carbon (TOC) and Chlorophyll a (chl.a) concentration were examined in the SeoNakdong river from January to December in 2014, to assess composition of phyto- and zoo-plankton variation, to certify the correlation between chl.a and TOC and to determine the level of contribution of plankton carbon content to TOC in the reservoir-river ecosystem. The correlation level between TOC and chl.a was low in the year 2014 but exceptionally was highly correlated only during the period with cyanobacterial bloom. The high level of contribution of plankton carbon content to TOC was attributed to cyanobacterial carbon biomass from May to November and to Cladocera carbon biomass from March to May, November and December despite of its low abundance. These results suggest that there were inter-relationships between phytoplankton, zooplankton and TOC and also subtle consistency of their properties through the year. These patterns should be discussed in relation to the physiochemical and biological characteristics of the environment, as well as to allochthonous organic matters from non-point pollution sources.

대학도서관에서의 정리업무 아웃소싱 품질관리에 관한 연구

이유정,Lee, You-Jeong 한국도서관정보학회 2009 한국도서관정보학회지 Vol.40 No.2

이 연구의 목적은 정리업무 아웃소싱을 시행하고 있는 대학도서관에서의 정리업무 품질관리 방안에 대해 논의하는 것이다. 이를 위해 선행연구를 조사하였고 실제 아웃소싱을 시행하고 있는 도서관에서의 품질관리현황에 대해 조사 분석하였다. 목록을 생산하고 품질을 관리하는 방식에 대해 논의하였고 정리 업무량의 변화를 분석하였다. 마지막으로 결론에서는 정리업무 아웃소싱의 품질 향상을 위해 다음을 제안하였다. (1) 품질에 대한 정의와 상세한 업무 매뉴얼을 개발하여 그에 따라 업무를 하도록 한다. (2) 자관의 핵심지식과 기술을 보유하고 이를 계속 전수할 수 있도록 한다. (3) 자체 교열시스템의 도입을 고려한다. (4) 도서관과 아웃소싱업체간의 긴밀한 의사소통을 유지한다. (5) 업체직원은 업무에 필요한 교육을 이수하도록 한다. This study was intended to investigate the quality control in technical services outsourcing in academic libraries. For this purpose, investigated related papers and the experience of outsourced technical services in three academic libraries. Data from senior librarians charged with revision of catalogs are gathered. Issues of catalogs production and quality control are explored and statistics of outsourcing is analysed. Quality control is a major factor of the success of technical services outsourcing operation. The some suggestions in order to enhance quality of vendor-supplied cataloging are presented.

편목시스템의 유용성 평가에 관한 연구

이유정,Lee, You-Jeong 한국문헌정보학회 2006 한국문헌정보학회지 Vol.40 No.1

이 연구의 목적은 대학도서관에서 사용하고 있는 편목시스템의 유용성을 평가하는 것이다. 이러한 목적을 위해 선행연구에 나타난 품질 평가기준을 분석하고 편목시스템의 유용성을 체계적으로 평가하기 위한 기준을 개발하였다. 개발된 4개의 평가기준과 24개의 항목을 기초로 하여 국내 3개 자동화시스템을 대상으로 편목사서들에게 설문조사를 실시하였다. 측정결과를 참조하여 편목시스템의 유용성을 종합적으로 검증하였다. 제안한 평가모델의 신뢰성과 타당성이 있는 것으로 검증되었으며 전반적인 만족도를 분석하였다. 이 연구는 향후 편목시스템의 유용성 향상을 위한 기준으로 활용될 수 있을 것이다. The purpose of this study intends to evaluate the usefulness of the automated cataloging systems. For the purpose. this study investigated theoretical methods for the quality criteria and developed 4 evaluation criteria. Also developed were indicators to measure the value of each criteria And the catalogers of academic libraries using three major LAS were carefully chosen to conduct the usefulness tests. The proposed model was verified reliability and validity. This study is suggested guidelines to evaluate and improve the automated cataloging systems.

정리업무 아웃소싱의 문제점 분석과 개선방안

이유정,Lee, You-Jeong 한국도서관정보학회 2007 한국도서관정보학회지 Vol.38 No.4

이 연구는 국내 대학도서관에서 정리업무 아웃소싱을 시행하고 있는 기관을 조사하여 현황을 분석하고 성공적인 아웃소싱을 시행하기 위한 방안에 대해 논의하였다. 선행연구에서 제시하는 아웃소싱 방법론에 대한 연구 분석을 기초로 하여 실제 아웃소싱을 시행하고 있는 기관에서 발견되는 아웃소싱의 문제점을 분석하였다. 제언을 포함한 결론에서는 아웃소싱을 시행하는 과정에서 인식해야 할 과제를 제안하였다. 아웃소싱의 모든 과정을 도서관에서 제어해야 하며 품질관리를 위한 정규직원이 배치되어야 한다는 점과 목록데이터의 품질유지를 위해 노력해야 한다는 점 등을 제안하였다. 이 연구는 정리업무 아웃소싱을 계획 혹은 시행하고 있는 대학도서관에서 실질적인 참고자료로 활용될 수 있을 것이다. This study aims to investigate and analyse the present of state and matters of technical services outsourcing in academic libraries. For the purpose summarized methods for outsourcing from reports and papers, suggested principal outline of outsourcing and developed quality control program of catalog. This study also surveyed several academic libraries in outsourcing and analyzed features and related issues of the operation of outsourcing. The results of this study can be refereed to the plan and implementation of technical services outsourcing in the future.

Fabrication of a Porous Ni-Based Metal with a Multi-pore Structure by a Screen Printing Process

이유정,Min‑Jeong Lee,Jung‑Yeul Yun,Byoung‑Kee Kim 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.5

Porous metals are commonly considered as having relatively excellent characteristics, such as a large surface area, light,lower heat capacity levels, high toughness, and good permeability. Ni alloys have high corrosion resistance, good heat resistanceand chemical stability for high-temperature applications. In this study, porous Ni-based metals for hydrogen reformercatalyst support are developed with Ni alloys, in this case Ni–Cr powder (28 μm), NiO powder (2 μm), and a fine Ni powder(< 1 μm). Ni–Cr powders are spread onto Al2O3substrate by a printing process. Ni-based foam is then placed on the printedpowder and a loading plate. These are sintered at 1200 °C under a high vacuum condition. The NiO powder and the fine Nipowder slurry are then screen-printed sequentially on the double structure (NiCr-coated Ni foam). In this study, the fine Nipowder is printed one, three, and five passes. The porous Ni alloys, which have double-pore structure, triple-pore structureand quadruple-pore structure, are fabricated by screen printing processes. With increased stacking of the pore structure,the porosity decreased from 86 to 82%, and the pore sizes decreased from 6.25 to 0.3 μm. The porosity and pore size of themulti-pore structure can be controlled by the size of powder and screen printing process.