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점액성 세관 방추세포 신장암종의 압착도말 세포소견 - 1예 보고 -
원규연,김교영,임성직,김현철,전승현,Won, Kyu-Yeoun,Kim, Gou-Young,Lim, Sung-Jig,Kim, Hyun-Cheol,Jeon, Seung-Hyun The Korean Society for Cytopathology 2008 대한세포병리학회지 Vol.19 No.2
The recent WHO classification has recognized mucinous tubular and spindle cell carcinoma (MTSCC) as a distinct entity of renal cell carcinoma, exhibiting a mixed pattern of tubules and a surrounding spindle cell proliferation within a myxoid stroma, with low-grade nuclear features. A 51-year-old woman had an incidentally discovered renal mass. Radiologic examination revealed a large, well defined mass in the lower pole of the right kidney; a right radical nephrectomy was performed. Imprint cytologic smears from fresh surgical specimens showed cellular, cohesive clusters with thick, broad trabecular arrangements and branching structures. On high power fields, the tumor was composed of round-to-oval low-grade nuclei with vesicular chromatin and small nucleoli. The tumor cells had indistinct borders and pale, eosinophilic cytoplasm, In some areas, round-to-elongated tubular structures and spindle cell patterns were noted. Chronic inflammatory cell infiltration was noted, along with a mucinous back-ground and occasional psammoma bodies. Neither significant cytologic atypia nor mitosis was seen.
투명세포신세포암에서 NF-κB의 발현과 임상병리인자에 관한 분석
이영(Young Lee),최정혁(Jeonghyouk Choi),이동기(Dong-Gi Lee),유구한(Koo Han Yoo),민경은(Gyeong Eun Min),이형래(Hyung-Lae Lee),원규연(Kyu Yeoun Won),임성직(Sung-Jig Lim) 대한비뇨기종양학회 2016 대한비뇨기종양학회지 Vol.14 No.2
Purpose: A multi-subunit transcription factor NF-κB is associated with anti-apoptotic signals in several cancers including renal cell carcinoma (RCC). In this study, we investigated whether the expression levels of the NF-κB were related to the clinical properties of human renal cell carcinoma such as nuclear grade, TNM stage, and recurrence free survival. Materials and Methods: Patients who were diagnosed with clear cell RCC between January 2006 and February 2013 were included. Clinicopathological data and survival were investigated. The expressions of NF-κB were investigated by performing immunohistochemical staining on 61 clear cell RCC. The expression levels of NF-κB were divided two groups by the expression levels. Results: Results on the expression of NF-κB were not significant. Analysis of NF-κB expressions is not associated with any of the clinical properties including age, nuclear grade and TNM stage (p=0.613, p=0.059, p=0.107, p=0.570, and p=0.760, respectively). Also, a statistically correlation was not observed between recurrence free survival and NF-κB expression levels (p=0.573). Conclusions: The expressions of the NF-κB were not associated with the clinical properties of clear cell RCC such as age, nuclear grade, TNM stage, and recurrence free survival.