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RAW 264.7 세포에서의 미역( Undaria pinnatifida )뿌리 에탄올 추출물의 항염증활성
강보영 ( Bo Kyeong Kang ),안나경 ( Na Kyong Ahn ),최연욱 ( Yeon Uk Choi ),김민지 ( Min Ji Kim ),박시우 ( Si Woo Bark ),박원민 ( Won Min Pak ),김보람 ( Bo Ram Kim ),김꽃봉우리 ( Koth Bong Woo Ri ),안동현 ( Dong Hyun Ahn ) 한국수산과학회 2014 한국수산과학회지 Vol.47 No.6
The anti-inflammatory effects of the ethanol extract ofUndaria pinnatifida root (UPREE) were investigated using the lipopolysaccharide (LPS)-induced inflammatory response in RAW 264.7 cells by measuring the production of nitric oxide (NO), interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-1β, and cell proliferation. We found that NO levels were reduced by 34% at 100 μg/mL. Moreover, the production of IL-6 and TNF-α was suppressed by the UPREE treatment. In particular, the IL-6 production was inhibited by more than 30% at 100 μg/mL UPREE. The proliferation of RAW 264.7 cells was measured by MTT assay, and we found no cytotoxicity in those cells treated with UPREE compared to the control. Our results suggest that UPREE shows promise as a therapeutic anti-inflammatory treatment.
참치( Katsuwonus pelamis ) 자숙액 농축물의 마우스 대식세포 및 비장세포에 대한 면역증강활성
강보경 ( Bo Kyeong Kang ),김꽃봉우리 ( Koth Bong Woo Ri ),안나경 ( Na Kyong Ahn ),최연욱 ( Yeon Uk Choi ),김민지 ( Min Ji Kim ),박시우 ( Si Woo Bark ),박원민 ( Bark Won Min ),김보람 ( Bo Ram Kim ),박지혜 ( Ji Hye Park ),배난영 ( Nan 한국수산과학회 2014 한국수산과학회지 Vol.47 No.6
Tuna cooking juice concentrate (TCJC) is by-produced during the canning processing of skipjack tuna Katsuwonus pelamis and it is well known that TCJC contains various nutritional components. Therefore, the immuno-stimulating activity of TCJC was investigated using macrophage RAW 264.7 cell line and the spleen cell isolated from BALB/c mice. The TCJC increased the production of IL-6, TNF-α, and IL-1β in a dose-dependent manner compared to the control in RAW 264.7 cells without any toxicity. In particular, the production of TNF-α was increased over 300-fold. The production of both Th1 cytokine (such as IFN-γ, TNF-α, IL-2, and IL-12) and Th2 cytokine (IL-4, IL-6, IL-10) was also increased by TCJC treatment in splenocytes. Moreover, the TCJC increased the splenocyte proliferation in a concentration-dependent manner compared to control. These results indicate that TCJC may enhance immune function by promoting various cytokine production.