멜라닌 세포성 종양의 임상 및 병리조직학적 고찰 ( 1974 ~ 1984 )

이대성(Dae Sung Lee),조백기(Baik Kee Cho),허원(Won Houh),심상인(Sang In Shim),정수일(Soo Il Chung) 대한피부과학회 1986 대한피부과학회지 Vol.24 No.3

This clinical and histopathological study was performed with 147 cases of benign mielanocytic tumors and 19 cases of malignant melanomas, which were obtained as surgical specimens from 1974 to 1984 at Department of Clinical Pathology, Catholic Medical College. The results were as follows: 1, In 89 cases of acquired benign melanocytic nevi, the average age of intradermal type(64 cases) was 34. 7 years and that of compound type(24 cases) was 24. 6 years. 2. In 30 cases of congenital nevus, nevus cells were present in the lower two thirds of reticular layer of the dermis in 93. 3% and in the subcutis as well in 3.3%. A case of giant congenital nevus with balloon cell appearance was found. 3. Of the 147 benign melanocytic tumors, a pigmented spindle cell nevus and a desmoplastic nevus were observed. 4. Blue nevi were 11 in number and excised from the face in 7, buttock in 2, shoulder in 1, upper arm in 1, and all were common type histopathologically. 5. Twelve malignant melanornas which were possible to be re-examined histopathologically were composed of 5 nodular type, 3 acral lentiginous type, 1 superficial spreading type and 3 metastatic malignant melanoma.

기능성 소화불량증 환자에서 자율신경 기능장애에 관한 연구

박동일(Dong Il Park),이풍렬(Poong Lyul Rhee),이용욱(Yong Wook Lee),김지은(Jee Eun Kim),현재근(Jae Geun Hyun),김창섭(Chang Sup Kim),장재권(Jae Kwon Jang),심상군(Sang Goon Shim),성인경(In Kyung Sung),김영호(Young Ho Kim),손희정(Hee Jun 대한소화기기능성질환·운동학회 2000 Journal of Neurogastroenterology and Motility (JNM Vol.6 No.2

N/A Background/Aims : The role of autonomic dysfunction in patients with functional dyspepsia has not been completely understood. The purposes of our study are (1) to prospectively assess the abnormalities of the autonomic function in patients with functional dyspepsia and (2) to assess whether the presence of autonomic dysfunction in patients with functional dyspepsia correlates with the presence of visceral hypersensitivity or with the severity of dyspeptic symptoms. Methods : Twenty eight patients with functional dyspepsia (4 men and 24 women; age range, 29-57) and 14 healthy volunteers without gastrointestinal symptoms (6 men and 8 women; age range, 23-61) were included in this study. All patients and controls were submitted to a battery of five standard cardiovascular autonomic reflex tests and gastric barostat tests. A modified version of the Glasgow Dyspeptic questionnaire was used in this study. Results : (1) Autonomic function tests showed that both sympathetic and parasympathetic scores of dyspeptic patients were significantly higher than those of the control group. (2) Visceral hypersensitivity could be confirmed in some of our dyspeptic patients in response to proximal gastric distension, demonstrating lower pain threshold in this group. (3) We could not find significant association between the presence of autonomic dysfunction and the presence of visceral hypersensitivity or severity of dyspeptic symptoms in patients with functional dyspepsia. Conclusion: Autonomic dysfunction was more prevalent in dyspeptic patients than in the control group. However, it did not correlate with the presence of visceral hypersensitivity or severity of dyspeptic symptoms. It is suggested that a defect in the spinal region or at the CNS level may be a major mechanism of visceral hypersensitivity in functional dyspepsia.

연구보문 : 자연과학 ; 수수 포장출현력 예측을 위한 종자세 적합도 검사

김석현 ( Seok Hyeon Kim ),이명희 ( Myeong Hee Lee ),강경희 ( Kyeong Hee Kang ),박민우 ( Min Woo Park ),심상인 ( Sang In Shim ),정정성 ( Jung Sung Chung ),나영왕 ( Young Wang Na ) 한국국제농업개발학회 2013 韓國國際農業開發學會誌 Vol.25 No.1

본 연구는 실험실에서 인위노화처리로 종자활력을 조절한 후 실시한 몇 가지 종자세 검정치와 포장출현력과의 관계를 설정하여 수수의 포장출현력 예측에 가장 적합한 종자세 검사 방법을 구명하고자 수행하였다. 수수 종자의 종자세가 높은 상태에서는 표준발아검사에서의 유아장이 포장출현력 예측에 효과적이며, 노화된 종자에서는 저온발아검사(CGT)에서의 정상묘율이 포장출현율과 높은 상관관계를 가지고 있었다(r = -0.998, p < 0.01). 포장출현력 예측에 효과적인 몇가지 종자세지수를 이용하여 stepwise multiple regression 분석을 실시한 결과 표준발아검사에서의 종자세 지수(vigor, SGT)가 95%의 높은 포장출현력 예측효과를 나타내었으며, 표준발아검사에서의 정상묘율(% normal seedling), 테트라졸리움의 종자세(vigor, TZ), 저온검사(cold test)에서의 정상묘율과 저온발아검사(CGT)에서의 정상 묘율과 같은 변수를 회귀방정식에 추가함에 따라 포장출현율 예측효율을 증가시킬 수 있었다. 표준발아검사와 저온발아검사는 노화정도가 다른 수수 종자의 종자세 검사방법으로 적합하다고 사료된다. In this study, several attempts were made to develop prediction method based on regression analysis for field emergence of sorghum using various seed vigor tests in laboratory. Sorghum seeds artificially aged to provide various levels of seed quality were evaluated by the standard germination test (SGT), cool germination test (CGT), cold germination test (CT), tetrazolium vigor test, electroconductivity test and complex stressing vigor test (CSVT). The most suitable criterion for identifying the degree of seed vigor was plumule length in the seeds shown higher seed vigor in the SGT. The field emergence rate and % normal seedling were highly correlated with performance in the aged condition (lowered seed vigor) of the CGT (r = -0.998, p < 0.01). In a multiple correlation analysis, seed vigor in the SGT accounted for 95% of the variation in seedling emergence in sorghum. Also, % normal seedling in SGT, TZ vigor test, % normal seedling in cold test (CT) and cool germination test (CGT) were useful for predicting field emergence in sorghum. The standard and cool germination tests therefore appear to be suitable for evaluating a wide range of seed vigor of sorghum seeds in field and could be used as a rapid vigor test.

위의 평활근 아세포종 1예

심상인(Sang In Shim),김승남(Seung Nam Kim),이재학(Jai Hak Lee),주상용(Sang Yong Choo),이종서(Jong Seo Lee),이준(June Lee) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.2

N/A The leiomyoblastoma of the stomach is an unusual smooth muscle tumor, which was first described by Martin and others in 1960. The gastric leiomyoblastoma is similar to the smooth muscle tumor of leiomyosarcoma in gross and composed of round or polygonal cells instead of spindle cells microscopically. Most of these tumors are benign but some tumors behave in malignant manner. The leiomyoblastoma has better prognosis than other smooth muscle tumors. Recently we experenced a case of leiomyoblastoma of the stomach and report with brief review of literatures.

기능성 소화불량증에서 13C - 요소호기검사의 DOB30 와 위근위부 운동기능과의 상관관계

심상군(Sang Goon Shim),이풍렬(Poong Lyul Rhee),현재근(Jae Gun Hyun),김지은(Jee Eun Kim),성인경(In Kyung Sung),장재권(Jae Kwon Jang),류광현(Kwang Hyun Ryu),김영호(Young Ho Kim),김재준(Jae J . Kim),고광철(Kwang Cheol Koh),백승운(Seung 대한소화기학회 2001 대한소화기학회지 Vol.38 No.6

Background/Aims: 13C-urea breath test (UBT) is accepted as an accurate test to detect Helicobacter pylori (H. pylori) infection. The results of UBT could be correlated with the extent of H. pylori colonization density or the severity of the gastric mucosal inflammation. We examined whether UBT values correlated with some parameters for proximal gastric motor functions in functional dyspepsia (FD). Methods: Twelve patients with FD and H. pylori infection confirmed by UBT were included. Breath samples were taken before and 30 min after 75 mg 13C-urea ingestion and analyzed by isotope mass spectrometry. The results of UBT were expressed as the difference between value at 30 min and value at baseline (DOB30). Gastric emptying scintigraphy and gastric barostat study were performed to measure the proximal gastric motor functions. Results: No significant correlation was found between DOB30 and proximal half-emptying time (r=-0.34, p=0.28), DOB30 and proximal gastric distribution of meal at 1 min images (r=0.03, p=0.93). According to the gastric barostat study, basal tone (r=0.53, p=0.07), compliance (r=-0.05, p=0.86), and gastric accommodation (r=-0.08, p=0.79) were not associated with DOB30. Conclusion: DOB30 does not correlate with proximal gastric motor parameters in patients with FD. (Korean J Gastroenterol 2001;38:405-410)

환경오염에 의한 산화스트레스와 식물체의 방어기작

심상인,강병화 ( Sang In Shim,Byeung Hoa Kang ) 한국환경농학회 1993 한국환경농학회지 Vol.12 No.3

The environmental pollutions were a serious problem in Korea recently. So many researcher have studied the effect of environmental pollution on plants and agro-ecosystem, but the basic mechanisms of environmental stresses were various. One of the important mechanisms was oxidative stress caused by active toxic oxygen. The toxic oxygen was generated by several stresses, abnormal temperature, many xenobiotics, air pollutants, water stress, fugal toxin, etc. In the species of toxic oxygen which is primary inducer of oxidative stresses, superoxide, hydrogen peroxide, hydroxyl radical and singlet oxygen were representative species. The scavenging systems were divided into two groups. One was nonenzymatic system and the other enzymatic system. Antioxidants such as glutathione, ascorbic acid, and carotenoid, have the primary function in defense mechanisms. Enzymatic system divided into two groups; First, direct interaction with toxic oxygen(eg. superoxide dismutase). Second, participation in redox reaction to maintain the active antioxidant levels(eg. glutathione reductase, ascorbate peroxidase, etc.).

기업규모별 도요타 생산시스템의 기업문화에 따른 생산관리 목표 및 경영성과의 차이분석

심상범(Shim, Sang Beom),유인선(Yoo, In-Seon) 한국상품학회 2009 商品學硏究 Vol.27 No.4

심상범,유인선 (2009)에서는 도요타 생산시스템의 기업문화가 도요타 생산시스템(ToyotaProductionSystem:TPS)적용에 대한생산관리 목표 및 경영성과에 상당한 연관관계가 있다는 것을 실증적으로 입증하였다.TPS를 도입하고 있는 제조업들은 구축된 기업문화 환경에서 TPS실행요인을 도입하여 생산관리 목표를 향상시키고 경영성과를 높이는 것으로 조사되었으며,특히 TPS기업문화에서 대하여는 중소기업과 대기업이 현저한 차이를 보여주었다. 이어지는 본 연구에서는 기업규모(대기업,중소기업)별 TPS적용시 기업문화 도입여부가 생산관리 목표 및 경영성과에 연관관계를 살펴보고,기업규모의 차이를 실증적으로 입증하고자 하였다.이를 통해 TPS도입 및 추진의 성공요인과 전략를 도출하고자 한다.연구결과 기업규모별 차이를 살펴보면 중소기업의 결과에서 TPS실행요인들이 기업문화와 유의한 상관관계가 있으며,TPS실행요인도 생산관리 목표와 경영성과에 유의한 영향을 미치는 것으로 나타났으나,도요타 생산시스템의 기업문화는 생산관리 목표에 영향이 저조한 것으로 나타났다.또한 대기업의 결과를 보면 도요타 생산시스템의 기업문화가 생산관리 목표에 많은 영향을 주는 것으로 나타났다. Previous research(Shim and Yoo 2009) found corporate culture in a Toyota Production System(here after referred to as TPS) to have a significant relationship with production goals and management performance.I t has was also known that manufacturing firms introducing TPS highly increased their production goals and performance. Their research also found that there were meaningful differences between SMEs(small and medium enterprises)and large firm sespecially by corporate culture. Extending this previous work, the present study attempted to investigate(1) how TPS implementation elements and organizational culture affect production goals (quality, cost, due date,a nd flexibility) and management performance including financial and non-financial, (2) whether any difference between SMEs and large firms exists among the sevariables, and(3)to finally help managers establish appropriate strategies for successfully implementing a TPS. The results of the study revealed that a significant difference existed between large and small & medium sized firms. Specifically, in the case of small & medium firms, TPS implementation elements significantly affected production goals, which in turn influenced management performance, and were highly correlated with corporate culture. However, nosignificant relationship between corporate culture and production goals was found. Findings also indicated that TPS implementation elements for large firms significantly affected both corporate culture and production goals, which in turn significantly affected management performance. These findings imply that firms with TPS implementation improved their production goals as well as performance.

모틸린에 의한 사람 위 평활근의 수축 기전에 관한 연구

심상군(Sang Goon Shim),이종철(Jong Chul Rhee),이풍렬(Poong Lyul Rhee),최규완(Kyoo Wan Choi),전성국(Sung Kook Jeon),강동묵(Tong Mook Kang),엄대용(Dae Yong Uhm),이종석(Jong Seok Lee),성인경(In Kyung Sung),김현서(Hyun Seo Kim) 대한소화기학회 2002 대한소화기학회지 Vol.39 No.1

Background/Aims: Motilin is an intestinal peptide that stimulates the contraction of gut smooth muscle. A discrepancy exists between the in vivo (neurally mediated) and in vitro (direct action on a smooth muscle receptor) mechanisms of motilin action in many species. We investigated in vitro mechanisms of motilin action on human gastric smooth muscle. Methods: Antral cirular muscle strips of the surgical tissue obtained during gastrectomy, were used to measure contractile force and electrical activity. Dispersed muscle cells were used to measure L-type Ca2+ current and electrical activity. Results: Motilin of 1-100nM contracted smooth muscle in a concentration-dependent manner. Motilin-induced contractions were unaffected by tetrodotoxin or atropine treatment. Nifedipine or Ca2+-free bath solution blocked motilin (10nM)-induced contractions. Low concentration of motilin (1nM) resulted in an increase in acetylcholine (0.1~100M)-induced contractions. By patch clamp recording technique, motilin (1 or 10nM) did not modify the L-type Ca2+ current, but motilin-induced membrane depolarization was detected. Erythromycin also contracted smooth muscle with membrane depolarization but verapamil inhibited the contraction. Conclusions: These results suggest that motilin contracts smooth muscle through a direct action on smooth muscle receptor and Ca2+ influx through the L-type Ca2+ channel, which is due to membrane depolarization, also mediates motilin-induced contractions. (Korean J Gastroenterol 2002;39:4-12)

내염성 식물의 탐색 및 생물학적 염해 모니터링 기술의 개발 2.염분 스트레스에 대한 작물의 출현과 초기 생장 반응

심상인 ( Sang In Shim ),이상각 ( Sang Gak Lee ),강병화 ( Byeung Hoa Kang ) 한국환경농학회 1998 한국환경농학회지 Vol.17 No.2

도요타 생산시스템의 기업문화가 생산관리 목표 및 경영성과에 미치는 영향

심상범(Shim, Sang Beom),유인선(Yoo, In-Seon) 한국상품학회 2009 商品學硏究 Vol.27 No.3

본 연구는 도요타 생산시스템의 기업문화가 도요타 생산시스템 적용에 대한 생산관리 목표 및 경영성과에 상당한 연관관계가 있다고 보고, 이것을 이론적으로 고찰하고 실증적으로 입증하고자 하였다. 또한 많은 기업들에게 기업경쟁력을 향상시킬 수 있는 올바른 도요타 생산시스템의 추진방법 및 성공요인의 제시를 해주기 위해서 시도된 논문으로서 기업의 성공적인 도요타생산시스템을 도입 및 구축하는데 기여할 수 있을 것이다. 본 연구에서는 도요타 생산시스템을 도요타 생산시스템의 실행요인과 도요타 생산시스템의 기업문화를 각각 독립변수로 보고 이를 이론적으로 체계화하고 실증적으로 확인하고자 하였다. 또한 도요타 생산시스템의 실행요인들이 도요타 생산시스템의 기업문화(학습리더십, 부서단위학습, 지속적인 학습, 자율적 역량증대, 조직문화, 지식공유 및 활동시스템)에 따라 생산관리 목표(품질, 원가, 납기, 유연성) 및 경영성과(비재무, 재무)에 영향을 미치는 정도에 대해서도 실증적으로 검증하였다. 제조기업 및 응답자에 대한 일반적 특성을 분석하기 위하여 빈도분석, 구조방정식 모형분석, 그리고 차이분석을 실시하였다. 회수된 설문지를 이용하여 연구의 목적을 달성하기 위해 통계분석은 한글 SPSS 14.0와 AMOS7.0를 활용하여 자료분석을 실시하였다. The Toyota production system (TPS) combines management philosophy and practices to form an integrated socio-technical system. This thesis focuses on the idea that the corporate culture has significant impact on production and management in TPS. Theoretical and positive studies are performed to establish the relationship between the corporate culture and production/management results(production goals and management performance). Through detailed analysis of TPS, this research provides companies with strategies for proper and successful implementation of TPS. TPS system is modeled using two independent groups of parameters, process tools and corporate culture. The TPS process tools group is composed of the following eight parameters; 5S, continuous improvement(Kaizen), visual management, TPM, Kanban, multi-skilled workers, production smoothing(Heijunka), autonomation(Jidoka). And the parameters constituting the corporate culture group are leadership training, departmental training, continuous training, autonomous ability organization, knowledge sharing and operation system. Characteristics of the survey responses and the Korean manufacturing industries are analyzed through frequency analysis, factor analysis, structural equation model analysis and exploratory analysis. Statistical analyses are performed using SPSS 14.0 and AMOS 7.0.