http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
다양한 신경학적 이상을 나타낸 glufosinate ammonium(바스타$^{(R)}$) 급성 경구 중독 1례
백진휘,김준식,이현규,박현주,하충건,노형근,Paik Jin Hui,Kim Jun Sig,Yi Hyeon Gyu,Park Hyun Joo,Ha Choong-Kun,Roh Hyung-Keun 대한임상독성학회 2005 대한임상독성학회지 Vol.3 No.2
BASTA is an herbicide which contains glufosinate ammonium as a main component with an anionic surfactant, polyoxyethylene alkylether sulfate, and nonselectively inhibits glutamine synthetase. It became a wildly used herbicide in Korea and its intoxication is now increasing. A 42-year old woman ingested about 300ml of BASTA in a suicide attempt. She showed unconsciousness and respiratory distress in the beginning, and later developed multiple generalized convulsions, low blood pressure, fever and diabetes insipidus. Although she became alert 12 days after the ingestion, she showed retrograde amnesia for a period of about recent 10 years. A neuropsychological test on day 22 revealed frontal lobe dysfunction, visual memory disturbance and slight decrease in visuospatial function. All these neurological abnormalities that might occur due to glufosinate ammonium were almost improved in the follow-up test performed a month later.
다양한 신경학적 이상을 나타낸 glufosinate ammonium(바스타®) 급성 경구 중독 1례
백진휘 ( Jin Hui Paik ),김준식 ( Jun Sig Kim ),이현규 ( Hyeon Gyu Yi ),박현주 ( Hyun Joo Park ),하충건 ( Choong Kun Ha ),노형근 ( Hyung Keun Roh ) 대한임상독성학회 2005 대한임상독성학회지 Vol.3 No.2
BASTA is an herbicide which contains glufosinate ammonium as a main component with an anionic surfactant, polyoxyethylene alkylether sulfate, and nonselectively inhibits glutamine synthetase. It became a wildly used herbicide in Korea and its intoxication is now increasing. A 42-year old woman ingested about 300ml of BASTA in a suicide attempt. She showed unconsciousness and respiratory distress in the beginning, and later developed multiple generalized convulsions, low blood pressure, fever and diabetes insipidus. Although she became alert 12 days after the ingestion, she showed retrograde amnesia for a period of about recent 10 years. A neuropsychological test on day 22 revealed frontal lobe dysfunction, visual memory disturbance and slight decrease in visuospatial function. All these neurological abnormalities that might occur due to glufosinate ammonium were almost improved in the followup test performed a month later.
강진아 ( Jin Ah Kang ),김강호 ( Kang Ho Kim ),백진휘 ( Jin Hui Paik ),홍대영 ( Dae Young Hong ),김지혜 ( Ji Hye Kim ),이경미 ( Kyoung Mi Lee ),김준식 ( Jun Sig Kim ),한승백 ( Seung Baik Han ) 대한외상학회 2006 大韓外傷學會誌 Vol.19 No.1
Penetrating facial wounds are uncommon and are usually life threatening because of the possibility of brain damage. There are three possible pathways for penetrating the cranium through the orbit: via the orbital roof, via the superior orbital fissure, or between the optic canal and lateral wall of the orbit. Brain injuries resulting from the penetrating wounds show extensive parenchymal damage, hemorrhage, and brain edema. Transorbital penetrating wounds can lead to diverse lesions of the optical apparatus, including the eye globe, the optical nerve, and the chiasm. Moreover, intracerebral structures may be hurt, and bleeding and infection may occur. Early diagnosis and prompt debridement are the fundamental factors affecting the outcome of a penetrating facial wound. An 87-year-old man was admitted to the emergency department with a grinder impacted into the medial aspect of the right eye. On presentation, the man was fully conscious with a Glasgow Coma Scale score of 15 and complained of a visual disturbance of the right eye. Computed tomography demonstrated a right orbital medial and inferior wall fracture, a frontal bone fracture, and a contusional hemorrhage in frontal lobe of the brain. A craniotomy with hematoma removal and repair of the orbital floor was done. He showed no neurological deficits except right visual loss. This appears to be the first report of a man with a penetrating facial wound caused by a grinder, who presented with a potentially disastrous craniocerebral injury that did not lead to any serious neurological seguelae. (K Korean Soc Traumatol 2006;19:89-92)
김재진 ( Jae Jin Kim ),윤성현 ( Sung Hyun Yun ),정현민 ( Hyun Min Jung ),김지혜 ( Ji Hye Kim ),한승백 ( Seung Baik Han ),김준식 ( Jun Sig Kim ),백진휘 ( Jin Hui Paik ) 대한임상독성학회 2013 대한임상독성학회지 Vol.11 No.1
Ethylene glycol poisoning is treated mainly by alcohol dehydrogenase inhibition therapy and hemodialysis. Early recognition and initiation of treatment is important because toxic metabolites increase over time by hepatic metabolism; however, there is no confirmative diagnostic tool in our clinical setting. Therefore, diagnosis is dependent on history, high anion gap acidosis, high osmolal gap, etc.. Diagnosis and treatment are delayed in cases where history taking is not possible, such as a mental changed patient. Authors report on two cases of ethylene glycol poisoning by contrasting clinical outcomes, demonstrating the importance of early diagnosis and treatment for achievement of a good outcome.
글리포세이트 중독 환자의 임상 양상 및 사망 관련 인자 분석
은희민 ( Hee Min Eun ),백진휘 ( Jin Hui Paik ),서주현 ( Joo Hyun Suh ),정진희 ( Jin Hee Jung ),어은경 ( Eun Kyung Eo ),노형근 ( Hyung Keun Roh ) 대한임상독성학회 2013 대한임상독성학회지 Vol.11 No.2
Purpose: Glyphosate is widely used and its toxic exposures are not rare. Occasionally, glyphosate intoxication can lead to death. The aim of this study is to analyze clinical findings and fatality in glyphosate intoxication. Methods: Clinical data on acute glyphosate intoxication were prospectively collected at 28 hospitals nationwide between August 2005 and July 2006. The patients’ clinical symptoms and characteristics of fatalities were investigated and statistical analysis was performed. Results: Among 105 patients who were finally included, gastrointestinal symptoms(59%) were the most common. A significant difference in the amount ingested was observed between patients with higher systolic blood pressure and those with systolic blood pressure less than or equal to 80 mmHg (p<0.001). The more the patients ingested, the more aggravated their mental status became (p=0.004). Seven patients(6.7%) died, and all of them had ingested greater than or equal to 200 ml. Patients who died had ingested greater amounts than the survivors (p<0.001), and their mental status was worse (p<0.001), and systolic blood pressure was lower (p<0.001). According to the result of logistic regression analysis, relative risk was 24.1-fold higher in the ‘poor’ mental status group compared with ‘good’. Conclusion: Patients who ingested large amounts of glyphosate showed poor mental status and lower blood pressure. Statistical difference in amount ingested, mental status, and systolic blood pressure was observed between survivors and patients who died. Ingested amounts and mental status were the most important factor of the prognosis of glyphosate intoxication.
유기인계 농약 중독 환자에서 중추신경 독성으로 지속적인 의식장애를 보인 1례
이재성 ( Jae Sung Lee ),백진휘 ( Jin Hui Paik ),윤성현 ( Sung Hyun Yun ),김지혜 ( Ji Hye Kim ),한승백 ( Seung Baik Han ),김준식 ( Jun Sig Kim ),정현민 ( Hyun Min Jung ) 대한임상독성학회 2013 대한임상독성학회지 Vol.11 No.1
Acute organophosphate intoxication is important because of its high morbidity and mortality. The mortality is still high despite the use of atropine as specific antidotal therapy and oximes for reactivation of acetylcholinesterase. Inhibition of acetylcholinesterase by organophosphate can cause acute parasympathetic system dysfunction, muscle weakness, seizure, coma, and respiratory failure. Acute alteration in conscious state or a coma, which may occur following organophosphate intoxication, is an indication of severe intoxication and poorer prognosis. This acute decline in conscious state often reverses when the cholinergic crisis settles; however, it may be prolonged in some patients. We report on a case of a 60-year-old male who showed prolonged decline in conscious state due to of Central Nervous System (CNS) toxicity after a suicide attempt with organophosphate.
정현민 ( Hyun Min Jung ),김지혜 ( Ji Hye Kim ),백진휘 ( Jin Hui Paik ),김준식 ( Jun Sig Kim ),김정훈 ( Jung Hun Kim ),한승백 ( Seung Baik Han ) 대한임상독성학회 2011 대한임상독성학회지 Vol.9 No.2
Aluminum phosphide is commonly used as a rodenticidal agent in agricultural workplaces. However, reported cases of aluminum phosphide poisoning in Korea are rare. Upon contact with moisture in the air, aluminum phosphide releases highly toxic phosphine gas (PH3). PH3 is readily absorbed through lung epithelium and into the bloodstream. Phosphine may cause denaturing of oxyhemoglobin and enzymes important to respiration and metabolism, and also may effect cellular membranes. There are numerous complications associated with acute aluminum phosphide poisoning including gastrointestinal, respiratory, and cardiac toxicities. We report the case of a 46-year-old man who suffered from respiratory and cardiac toxicities after unintentional aluminum phosphide exposure. More intensive education for prevention is recommended.
김도영 ( Do Young Kim ),김지혜 ( Ji Hye Kim ),백진휘 ( Jin Hui Paik ),한승백 ( Seung Baek Han ),정현민 ( Hyun Min Jung ) 대한임상독성학회 2017 대한임상독성학회지 Vol.15 No.2
Purpose: This study was conducted to analyze the features of poisoning in individuals aged 0-18 years to understand the characteristics of potential victims and eventually prevent poisoning. Methods: We retrospectively analyzed poisoned children and adolescents (0-18 years) who visited the emergency department of one tertiary hospital from January 2003 through December 2013. We collected data including their age, sex, reason for poisoning, components and dose of poison, results of treatment, and psychiatric diagnosis. Results: During the study period, there were 436 cases of poisoning (male 47.2% (n=206); female 52.8% (n=230)). Subjects were classified into four groups (0-1 years, 2-5 years, 6-12 years, 13-18 years). The most common cause of poisoning in all age groups was accidental poisoning (72.9%), but intentional poisoning increased as age increased (p<0.001). Moreover, females were more often subject to intentional poisoning than males (p<0.001). The most common poisoning material was drugs (41.7%). Among intentional poisoning patients, 62.7% patients had consulted a psychiatrist, and their most common diagnosis was adjustment disorder (44.6%). Conclusion: The most common cause of poisoning in individuals aged 0-18 years was accidental poisoning, while intentional poisoning was most common among adolescents. Guardians should take care to prevent accidental poisoning, while psychiatric consultation and national moderation will be needed to prevent intentional poisoning.
정현민 ( Hyun Min Jung ),은희민 ( Hee Min Eun ),백진휘 ( Jin Hui Paik ),김지혜 ( Ji Hye Kim ),김준식 ( Jun Sig Kim ),한승백 ( Seung Baik Han ) 대한임상독성학회 2012 대한임상독성학회지 Vol.10 No.2
Chromic acid is a strong metal acid and acute poisoning is very rare. However, chromic acid causes serious complications, such as skin injuries, as well as renal and hepatic failure. We report on a case of a 47-year-old male who accidentally had chromic acid spilled over his nose and face. For the first few days, he was treated with ascorbic acid and massive hydration. However, after three days, his condition began to worsen. He was treated with hemodialysis for anuria and acute renal failure, and antibiotics for pneumonia. On day 10 of hospitalization, he expired of multi-organ failure. We suggest firm control and close supervision of chromic acid in the work place, and, considering severe complications of chromic acid, we propose a nearly and aggressive treatment.
정현민 ( Hyun Min Jung ),김지혜 ( Ji Hye Kim ),한승백 ( Seung Baik Han ),백진휘 ( Jin Hui Paik ),김지윤 ( Ji Yoon Kim ),김준식 ( Jun Sig Kim ) 대한임상독성학회 2010 대한임상독성학회지 Vol.8 No.2
Basagran® is a herbicide that is widely used in the field and it acts by interfering with photosynthesis in plants. It consists of bentazone, 2-methyl-4-chloro phenoxyacetic acid (MCPA) and surfactants. Bentazone is commonly used, but poisoning due to Bentazone has not been previously reported in Korea. The patients with toxic effects of bentazone show mild to severe symptoms and various complications. We report here on a case of a woman who intentionally ingested 500 ml of Basagran® and she was discharged without complication. As soon as the patient visited the emergency department, we started to treat her as if she had organophosphate intoxication because of the cholinergic symptoms. We could not detect the bentazone in her serum and urine, and we could confirm Basagran® ingestion only after getting information from her husband. Bentazone poisoning may induce harmful complications like muscle rigidity, rhabdomyolysis, respiratory failure and cardiac arrest. A detailed history taking, an accurate analysis method and early conservative management will be helpful for patients with acute bentazone poisoning.