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김성현 ( Sung Hyun Kim ),이재천 ( Jae Chun Lee ),김수희 ( Su Hee Kim ),김현우 ( Hyun Woo Kim ),김영욱 ( Young Uck Kim ),임영협 ( Young Hyup Lim ),문신항 ( Shin Hang Moon ),문재철 ( Jae Cheol Moon ),허다희 ( Da Hee Heo ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 1991 소아알레르기 및 호흡기학회지 Vol.1 No.2
Eperisone hydrochloride is an antispasmodic drug, decreasing spasticity of skeletal muscle and alleviating stiffness, and as a consequence, controlling pain. It is preferably prescribed with other analgesics, beneficially less decreasing alertness compared with other antispasmodics. Its fatal drug adverse reactions were rarely reported. A 70 year-old female with hives, swollen face, hoarse voice, and near fainting admitted via emergency department. She suffered from the series of the fatal symptoms after administration of the pills, prescribed for her neck pain. Two months before, she had experienced hives on similar medications. At presentation, she revealed hypoxemia and hypotension, and treated with epinephrine, glucocorticoids and antihistamines. Among the medicines she took, eperisone hydrochloride was proven as the causative medicine and others were excluded in oral provocation tests. The positive result in intradermal test with eperisone hydrochloride suggested immediate-type hypersensitivity reaction. We report a case of anaphylaxis to eperisone hydrochloride, one of the widely prescribed medicines in clinical practice, previously without awareness of drug adverse reaction. (Allergy Asthma Respir Dis 2013;1:172-175)
김성현 ( Sung Hyun Kim ),이재천 ( Jae Chun Lee ),김수희 ( Su Hee Kim ),김현우 ( Hyun Woo Kim ),김영욱 ( Young Uck Kim ),임영협 ( Young Hyup Lim ),문신항 ( Shin Hang Moon ),문재철 ( Jae Cheol Moon ),허다희 ( Da Hee Heo ) 대한천식알레르기학회 2013 Allergy Asthma & Respiratory Disease Vol.1 No.2
Eperisone hydrochloride is an antispasmodic drug, decreasing spasticity of skeletal muscle and alleviating stiffness, and as a consequence, controlling pain. It is preferably prescribed with other analgesics, beneficially less decreasing alertness compared with other antispasmodics. Its fatal drug adverse reactions were rarely reported. A 70 year-old female with hives, swollen face, hoarse voice, and near fainting admitted via emergency department. She suffered from the series of the fatal symptoms after administration of the pills, prescribed for her neck pain. Two months before, she had experienced hives on similar medications. At presentation, she revealed hypoxemia and hypotension, and treated with epinephrine, glucocorticoids and antihistamines. Among the medicines she took, eperisone hydrochloride was proven as the causative medicine and others were excluded in oral provocation tests. The positive result in intradermal test with eperisone hydrochloride suggested immediate-type hypersensitivity reaction. We report a case of anaphylaxis to eperisone hydrochloride, one of the widely prescribed medicines in clinical practice, previously without awareness of drug adverse reaction. (Allergy Asthma Respir Dis 2013;1:172-175)Allergy Asthma Respir Dis 2013;1:172-175)